Protein Alignment Shal and Kcng2

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_001100842.1
• Gene: Kcng2 / 307234
• RGDID: 1309521
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 445
• Identity: 143/445 - (32%)
• Similarity: 221/445 - (49%)
• Gaps: 65/445 - (14%)

  Fly    24 HPLPPPPMP-------KDRRKTDDEKLLINVSGRRFETWRNTLEKYP-------------DTLLG 68
            ||..|...|       :..|......::|||.|.|.......|.:.|             |.||.
  Rat     7 HPEVPGAEPGSAVRGGRGGRGARARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDELLR 71

  Fly    69 SNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCC 133
            ..:.   ||....|:||||.|..||.|:...|.|||...:..|..::.:|||::||....:..||
  Rat    72 VCDD---YDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCC 133

  Fly   134 YEDYRDRKRENAE---------------RLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTS 183
            ....|.|:.|.||               |.:.....|.|.:.|:.:.          ||||:..:
  Rat   134 LRRLRRREEEAAEARATPPARGPQTSPGRALGSGRLERGRRRLRDVV----------ENPHSGLA 188

  Fly   184 ALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRL 248
            ..:|.||:..|:||:.:...:.|:|........|  .|..:.:.: |.|:|.||..|:.|:|||.
  Rat   189 GKLFAYVSVAFVAVTAVGLCLSTMPDVRAEEERG--ECSTKCRNL-FVLETVCVAWFSFEFLLRS 250

  Fly   249 FAAPDRCKFVRSVMSIIDVVAIMPYYIGL------GITDNDDVSGAFVTLRVFRVFR---IFKFS 304
            ..|..:|.|:|:.::|||::||:|:|:.|      |.|.:..:..|.:.||:.|..|   :.:.:
  Rat   251 LQAESKCAFLRTPLAIIDILAILPFYVSLLAGLAAGPTGSKMLERAGLVLRLLRALRVLYVMRLA 315

  Fly   305 RHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNG-TNFTSIPAAFWYTIVTM 368
            |||.|||.||.|::.||.|.|.|:..|.:|:.:||.::..||:.:.. .:|:|:||::|:.:::|
  Rat   316 RHSLGLRSLGLTVRRCAREFGLLLLFLCVAMALFAPLVHLAERELGAHRDFSSVPASYWWAVISM 380

  Fly   369 TTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIY----HQNQRA 419
            ||:|||||||.::.|::|.....|||:|::|.||..|...|||.|    .|.|||
  Rat   381 TTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRA 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	40/139 (29%)
		Ion_trans	188..415	CDD:459842	87/240 (36%)
		DUF3399	471..535	CDD:463381
Kcng2	NP_001100842.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		4/17 (24%)
		BTB_POZ_Kv6_KCNG	33..127	CDD:349691	31/96 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..167		3/22 (14%)
		Ion_trans	190..429	CDD:459842	88/241 (37%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	382..387		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..480		4/7 (57%)