Protein Alignment Shal and Kcnb1

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_037318.2
• Gene: Kcnb1 / 25736
• RGDID: 2954
• Length: 857
• Species: Rattus norvegicus
• Alignment Length: 531
• Identity: 186/531 - (35%)
• Similarity: 282/531 - (53%)
• Gaps: 53/531 - (9%)

  Fly    22 ATHPLPPPPMPKDRRKTDDEKLLINVSGRRFET-WRNTLEKYPDTLLGS----NEREFF------ 75
            :|..|||.||...|.|....::.:||.|...|. || ||::.|.|.||.    |..:..
  Rat    12 STSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWR-TLDRLPRTRLGKLRDCNTHDSLLQVCDD 75

  Fly    76 YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDR 140
            |..:..||||||.|..|..|||:||||:||..:..|..|:.:||.::||....:..||...|..:
  Rat    76 YSLEDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQK 140

  Fly   141 KRENAERL------MDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSV 199
            |.:..|.|      :.::..|..|...  ....|:|:|...|.|::|.:|.:...::..||.:|.
  Rat   141 KEQMNEELKREAETLREREGEEFDNTC--CAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLST 203

  Fly   200 MANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSI 264
            :|..:.|:|........|......:...|    :..|:..||.|||||..::|.:.||.:..::.
  Rat   204 IALSLNTLPELQSLDEFGQSTDNPQLAHV----EAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNA 264

  Fly   265 IDVVAIMPYYIGLGITDND-------DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322
            ||::||:|||:.:.:|:::       :|.......|:.|:.||.|.:|||.||:.||:||:...:
  Rat   265 IDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYN 329

  Fly   323 ELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVG 387
            |||.|:..|||.|:||::::|:|||:.:.|.|.||||:||:..:||||:||||:.|:|:.|||||
  Rat   330 ELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVG 394

  Fly   388 GVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVS-KKKAA 451
            |:|.::||||||||:|:||:|||..|.:.:|.:|...:|:|      :.:|....:.|| ..|.|
  Rat   395 GLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREA------LERAKRNGSIVSMNMKDA 453

  Fly   452 EARWAAQESGIELDD---NYRDEDIF---ELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSP 510
            .||      .||:.|   ....|.|.   ::|.:||.....|.|.|...|.....:.:.|..|||
  Rat   454 FAR------SIEMMDIVVEKNGESIAKKDKVQDNHLSPNKWKWTKRALSETSSSKSFETKEQGSP 512

  Fly   511 S---PMASPAH 518
            .   ..:||.|
  Rat   513 EKARSSSSPQH 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	49/132 (37%)
		Ion_trans	188..415	CDD:459842	96/233 (41%)
		DUF3399	471..535	CDD:463381	16/54 (30%)
Kcnb1	NP_037318.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		4/8 (50%)
		BTB_POZ_KCNB2	15..141	CDD:349719	47/126 (37%)
		Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160	59..75		1/15 (7%)
		Ion_trans	188..424	CDD:459842	97/239 (41%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	377..382		3/4 (75%)
		Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160	448..481		10/38 (26%)
		Kv2channel	467..678	CDD:397541	16/57 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..524		14/48 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	540..569
		FFAT. /evidence=ECO:0000250|UniProtKB:Q14721	590..596
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..658
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..802
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..857