Protein Alignment Shal and Kcna6

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_038596.1
• Gene: Kcna6 / 16494
• MGIID: 96663
• Length: 529
• Species: Mus musculus
• Alignment Length: 449
• Identity: 160/449 - (35%)
• Similarity: 238/449 - (53%)
• Gaps: 82/449 - (18%)

  Fly    41 EKLLINVSGRRFETWRNTLEKYPDTLLGS-NEREFFYDEDCKEYFFDRDPDIFRHILNYYRT-GK 103
            |:|:||:||.||||...||..:||||||. ..|..|:|....||||||:...|..||.||:: |:
Mouse    41 ERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGR 105

  Fly   104 LHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTN-- 166
            |..|.:..|..:.||:.|:     .:|:.....:|:          |:.....|.::.:.|.:
Mouse   106 LRRPVNVPLDIFMEEIRFY-----QLGEEALAAFRE----------DEGCLPEGGEDEKPLPSQP 155

  Fly   167 MRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRA--------------- 216
            .::::|..||.|.:|..|.....|:...|.:|::...:||:|.....||.
Mouse   156 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRADGRGGSNEGSGTRLSPASR 220

  Fly   217 ---------------GTLPC---------------GERYKIVFFCLDTACVMIFTAEYLLRLFAA 251
                           |::|.               |..:...||.::|.|::.||.|.|:|..|.
Mouse   221 SHEEEDEDEDSYAFPGSIPSGGLGTGGTSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSAC 285

  Fly   252 PDRCKFVRSVMSIIDVVAIMPYYIGLGIT-----DNDDVSGA-------------FVTLRVFRVF 298
            |.:..|.|::|:|||:|||.||:|.||..     :...|||.             ...:|:.|||
Mouse   286 PSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQSVSGGSGQNGQQAMSLAILRVIRLVRVF 350

  Fly   299 RIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWY 363
            ||||.||||:||:|||.||::...|||.|:|.|.:.:|:|::.:::||.:...:.|.|||.|||:
Mouse   351 RIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDVDSLFPSIPDAFWW 415

  Fly   364 TIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 422
            .:|||||:|||||.|.|:.|||||.:|:::|||.||||||||||||:..||:....:::
Mouse   416 AVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQ 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	41/104 (39%)
		Ion_trans	188..415	CDD:459842	109/289 (38%)
		DUF3399	471..535	CDD:463381
Kcna6	NP_038596.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35
		BTB_POZ_KCNA6	41..170	CDD:349714	48/143 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..238		3/34 (9%)
		Ion_trans	259..468	CDD:459842	99/208 (48%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	360..373		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	422..427		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..513
		PDZ-binding. /evidence=ECO:0000255	527..529