Protein Alignment Shal and Kcna4

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_067250.2
• Gene: Kcna4 / 16492
• MGIID: 96661
• Length: 654
• Species: Mus musculus
• Alignment Length: 469
• Identity: 165/469 - (35%)
• Similarity: 263/469 - (56%)
• Gaps: 72/469 - (15%)

  Fly    41 EKLLINVSGRRFETWRNTLEKYPDTLLGSNE-REFFYDEDCKEYFFDRDPDIFRHILNYYRT-GK 103
            |:::|||||.||||...||.::|:||||..| |..::|....||||||:...|..||.||:: |:
Mouse   177 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR 241

  Fly   104 LHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDK-LSENGDQNLQQLTNM 167
            |..|.:.....:.||:.|:.:..:.:       .:.|:.|...|..:|: |.||         ..
Mouse   242 LKRPVNVPFDIFTEEVKFYQLGEEAL-------LKFREDEGFVREEEDRALPEN---------EF 290

  Fly   168 RQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGR--AGTLPCGERYKIV-- 228
            ::::|..||.|.:|:.|.....|:...|.:|::...:||:| ..|..|  ...|..|...:::
Mouse   291 KKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLP-EFRDDRDLIMALSAGGHSRLLND 354

  Fly   229 -----------------FFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIG 276
                             ||.::|.|::.|:.|:::|.||.|.:..|.:::|:|||:|:|:||:|.
Mouse   355 TSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFIT 419

  Fly   277 LGITDNDDVSG----------AFVTLRVF---RVFRIFKFSRHSQGLRILGYTLKSCASELGFLV 328
            || ||.....|          :|..||:.   |||||||.||||:||:|||:||::...|||.|:
Mouse   420 LG-TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLI 483

  Fly   329 FSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLS 393
            |.|.:.:|:|::.:::||.:...|:|.|||.|||:.:|||||:|||||.|.|:.|||||.:|:::
Mouse   484 FFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIA 548

  Fly   394 GVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIA------------KASSGAAFVS 446
            |||.||||||||||||:..||:     :.:.:.:.:|.:..::            ::|:.::...
Mouse   549 GVLTIALPVPVIVSNFNYFYHR-----ETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGD 608

  Fly   447 KKKAAEARWAAQES 460
            |.:..|.....:||
Mouse   609 KSEYLEMEEGVKES 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	38/104 (37%)
		Ion_trans	188..415	CDD:459842	108/260 (42%)
		DUF3399	471..535	CDD:463381
Kcna4	NP_067250.2	K_channel_TID	1..>37	CDD:429748
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..145
		BTB_POZ	177..304	CDD:453885	48/142 (34%)
		Ion_trans	307..571	CDD:459842	110/270 (41%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	463..476		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	525..530		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	630..654
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385	652..654