Protein Alignment Shal and kcnb2

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: XP_002937117.3
• Gene: kcnb2 / 100489419
• XenbaseID: XB-GENE-989392
• Length: 901
• Species: Xenopus tropicalis
• Alignment Length: 562
• Identity: 187/562 - (33%)
• Similarity: 289/562 - (51%)
• Gaps: 76/562 - (13%)

  Fly    22 ATHPLPPPPMPKDRRKTDDEKLLINVSGRRFET-WRNTLEKYPDTLLGS----NEREFF------ 75
            :|..|||.|:...|.|....::.|||.|...|. || ||::.|.|.||.    |..|..
 Frog    16 STLSLPPEPVEIIRSKACSRRVKINVGGLNHEVLWR-TLDRLPRTRLGKLRDCNTHESLLEVCDD 79

  Fly    76 YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDR 140
            |:.:..||||||.|..|..|||:|||||||..:..|..|:.:||.::||....:..||...|..:
 Frog    80 YNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQK 144

  Fly   141 KRENAERL------MDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSV 199
            |.:..|.|      :.::..|..|...  ....|:|:|...|.|::|.:|.:...::..||.:|.
 Frog   145 KEQMNEELRREAETLREREGEEFDNTC--CPEKRKKLWDLLEKPNSSVAAKILAIISILFIVLST 207

  Fly   200 MANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSI 264
            :|..:.|:|........|......:...|    :..|:..||.|||||..::|::.||.:..::|
 Frog   208 IALSLNTLPDLQETDEFGQPNDNPQLAHV----EAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNI 268

  Fly   265 IDVVAIMPYYIGLGITDND-------DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322
            ||::||:|||:.:.:|:::       :|.......|:.|:.||.|.:|||.||:.||:||:...:
 Frog   269 IDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYN 333

  Fly   323 ELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVG 387
            |||.|:..|||.|:||::::|:|||:.:.|.||||||:||:..:||||:||||:.|:|:.|||||
 Frog   334 ELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVG 398

  Fly   388 GVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKK-KAA 451
            |:|.::||||||||:|:||:|||..|.:.:|.:|...:|:|      :.:|....:.||.. |.|
 Frog   399 GLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREA------LERAKRNGSIVSMNLKDA 457

  Fly   452 EARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSPSPMASP 516
            .||      .:||.|                ..::|:.|           |..|.........||
 Frog   458 FAR------SMELID----------------VVVDKSAD-----------GSNKMEKPSDNHLSP 489

  Fly   517 AHSTNSAAGLLQSCCGRCCSQRYQACGKYMPAASNAQNSQNN 558
            :....|...|.::...:....:||...::     ::|...||
 Frog   490 SRWKWSRRTLSETSSNKSFDNKYQEVSQH-----DSQEQLNN 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	51/132 (39%)
		Ion_trans	188..415	CDD:459842	98/233 (42%)
		DUF3399	471..535	CDD:463381	8/63 (13%)
kcnb2	XP_002937117.3	BTB_POZ_KCNB2	19..145	CDD:349719	49/126 (39%)
		Ion_trans	192..428	CDD:459842	99/239 (41%)
		Kv2channel	471..755	CDD:397541	13/72 (18%)