Protein Alignment Ltn1 and RKR1

DIOPT Version :9

• Sequence 1: NP_730427.1
• Gene: Ltn1 / 40127
• FlyBaseID: FBgn0262517
• Length: 1747
• Species: Drosophila melanogaster
• Sequence 2: NP_013975.1
• Gene: RKR1 / 855289
• SGDID: S000004861
• Length: 1562
• Species: Saccharomyces cerevisiae
• Alignment Length: 1913
• Identity: 352/1913 - (18%)
• Similarity: 657/1913 - (34%)
• Gaps: 619/1913 - (32%)

  Fly    60 PDSFDAAISPQTQIILRKLSKKDPMTKKKALQELHELIEQ--------SDVEVLKNILPLWPKYY 116
            |...::..|.:.::|.:.|.|:|..||:|||.:|..||..        :|:.:|     .|.:.|
Yeast    36 PSLLNSLYSNELKLIFKSLLKRDETTKEKALMDLSNLISDFNQNEYFFNDIFLL-----CWSQIY 95

  Fly   117 LNLASDPEHTVREQTQTVLQLLMAKCKKAMAPYLKLLVP-VWLGS---RFDTYAPAASIASQSF- 176
            ..|.......:|.|:..:..:|:...:|.::.:||..:| :.||:   .:....|:.:..::.|
Yeast    96 AKLIISDYKVIRLQSHQITIMLVKSLRKKISKFLKDFIPLILLGTCELDYSVSKPSLNELTECFN 160

  Fly   177 RDTFAGNANRSREVCMHCQVEILEYATRNLTFHTAATLSIGKSLTPEDAEQKYQRVIISSLKLL- 240
            :|....||     :....|.::|......:......|:|..:..:.|::|.:|.|||.|::.||
Yeast   161 KDPAKINA-----LWAVFQEQLLNLVKEIVVNENEDTISDERYSSKEESEFRYHRVIASAVLLLI 220

  Fly   241 -SFFMGQTAQTEELSQVKEGFGTLVAHQKFWSFAKHKVPAIKAAWFECIYHILQSVALLDVITPQ 304
             .|...:.......|.:|    .:::.:..|.                         ||::...|
Yeast   221 KLFVHNKDVSERNSSSLK----VILSDESIWK-------------------------LLNLKNGQ 256

  Fly   305 KTQLTNLCFQFIDDADPVVAPHIWGCVLLLQSNYVDWFVP--LNIRKTLLPKLSSLLQNGFNRNA 367
            .|.......:.||             ||     |...::|  .||.|..:.||...|.:..::|.
Yeast   257 NTNAYETVLRLID-------------VL-----YTRGYMPSHKNIMKLAVKKLLKSLTHITSKNI 303

  Fly   368 QAICPNLLPFLSKVTQASLQDLDIYDFYQRFFDDMKLAVTKKFDPPLSKSDCIVIHNAYFECLRF 432
            ..:|| :||.:..:    |..||.|:                 |..:...|
Yeast   304 LKVCP-VLPSILNL----LATLDDYE-----------------DGTIWSYD-------------- 332

  Fly   433 LMQQINNNKQREQKEEEFSFSLLDNNVLEP-----IAWLLKSDSTHVKIFFQHSSALVAFWDRQI 492
                      :..||:...|..:......|     :..|..|...|  .|..:....:.||.:.:
Yeast   333 ----------KSSKEKVLKFLSVSRTSPSPGFFNAVFALYSSTKRH--SFLDYYLEWLPFWQKSV 385

  Fly   493 NNRLDNG---DLYAKLLNKFWIRIFELVTQDLSAEEVNEQLLGHVLLLVQDLHMANPSLESPSVK 554
            ....:.|   ...|::||:||...                                       :|
Yeast   386 QRLNEKGFSARNSAEVLNEFWTNF---------------------------------------LK 411

  Fly   555 FVEGPNEKIEKSEPTTPVKKAQEAAAFIQKELKQLVIKLVRICLDKANKGSGSGTSSSRYIEQIR 619
            |.|..:|:        .|||..|:..|                     .....|.|.|.|.:..:
Yeast   412 FAEDSSEE--------RVKKMVESEIF---------------------NSLSCGKSLSEYTKLNQ 447

  Fly   620 TLTKMFNDAAFYKSL----TDDGDLASALNKFVSLLGQLSCQACESVVEIVFEILPLLETGKRFE 680
            ||:.:|....:.:.:    |.|.|:..                    :::.||
Yeast   448 TLSGVFPPDKWEREIEDYFTSDEDIRK--------------------IKVSFE------------ 480

  Fly   681 YIENTLMKLPQHGVQNLLLHRLLSYPLCAEAAVRQMLSGPETCEMIARIAEEVVVDNDREKLNLL 745
                          :||.               ..:::.|.....|:|:.:..|...:.:..|:.
Yeast   481 --------------KNLF---------------ALLVTSPNNESAISRLFDFFVQLIETDPSNVF 516

  Fly   746 HKCFFQTDTGDILINAKTVDKILLSMCGPLEQPVVDDAVEVCGSFIAQIMPVICSNNNSSLHVRQ 810
            :|                                .|...:....|:...|
Yeast   517 NK--------------------------------YDGVYDALNYFLDSDM--------------- 534

  Fly   811 HIFL--KLFKFSLEHRPEDYLSEDTLWEITTCWQDGLSSKDIEIDDDMLKCCAGIVEELANSAEL 873
             |||  |:.||              :.||.|.           :.:...:..|||:.:.:||...
Yeast   535 -IFLNGKIGKF--------------INEIPTL-----------VQESTYQNFAGIMAQYSNSKFF 573

  Fly   874 KADT----------LDGMAEAMAKFVICSTEN--IEDEYKRLERIDETLTALLETPLKTTDKVQQ 926
            |.:|          :..::..:.|.:|.:|.|  ..|.|::|.:.|.     ||..|...|.::.
Yeast   574 KMNTDAITSLEDFFIVALSFNLPKTIILATMNELDNDIYQQLMKSDS-----LELELYIEDFMKN 633

  Fly   927 FE----------NHCVL----LEALHGSVTAGVPFENACLSRNEILPLLQR---STLNFSTIYKL 974
            ::          |:..|    :..|:.|..|....|..|    .:|..|..   |||..:|.:..
Yeast   634 YKFDDSGEIFKGNNKFLNQRTITTLYRSAVANGQVEQFC----AVLSKLDETFFSTLLLNTDFLS 694

  Fly   975 VYQFPPPQDTNDPEDELTEDYCDPNADVLKKWNEPLIAELLQCIRV---AGTAECWLEMSVLQSS 1036
            ...:...:|||:...:|:......|:::..|    |...:||..:|   .|..|.::..:|
Yeast   695 CALYEVSEDTNEKLFKLSLQLAKGNSEIANK----LAQVILQHAQVYFSPGAKEKYVTHAV---- 751

  Fly  1037 TEELVLILSEKVQSFM-GNSSDLVAIVKERLQQAAVQQSSVIDCRLLSYLRFCPQYAAFEESASI 1100
              ||:...::..|.|. .|:.::.|    |...|...:||::              ::...:..:
Yeast   752 --ELINGCNDTSQIFFPANAIEVFA----RYMPAIDYRSSLV--------------SSLSTNTHL 796

  Fly  1101 LLHEDLSENLVTQGALKTYVIALQFLLPKLSQKA-------ITLSSAI------MGTEPPEIWVK 1152
            ||.:|...||.....|..|.:.|..||..|.::.       ||:.|.:      :..||.:::..
Yeast   797 LLTDDKPINLKNMQKLIRYALFLDALLDALPERVNNHIVAFITVVSELVTDYNCLSEEPNDLYYD 861

  Fly  1153 ------------------------------------------------AAVFHALLLNNFEGDVN 1169
                                                            :.|.:.:|||:.: .|:
Yeast   862 FGHTFFKHGKVNLNFSDIVGNVIQPANGGDAMLTFDIAESNSVYFFYYSRVLYKVLLNSID-TVS 925

  Fly  1170 EQTDRNIIVSAVQFMT-SIGERQASQKD-------LLHYN------------------------V 1202
            ..|...::.|...|:| ::.:::::.||       ||.:|                        |
Yeast   926 STTLNGLLASVESFVTKTVRDQKSTDKDYLLCAILLLMFNRSNSKDEITKLRTLLASQLIGIREV 990

  Fly  1203 EIQRQPYESVINTVEFIKLLTEVL------KRF----PYELSIKNWDAIRIGLSSWVLSVSKSIA 1257
            |:..|.::|       :.||..:|      |:|    |..|::                :.:||.
Yeast   991 ELVDQEFKS-------LALLNNLLDIPQADKQFVPIAPQRLNM----------------IFRSIL 1032

  Fly  1258 QYQD------PKTSLFIVAVYELFAALIDF--IR---------SEKQKSSTELLKNMIDEWDSLF 1305
            ::.|      |..|...:.:.:.|..|:.|  :|         ||:..:.: |....||  |:|:
Yeast  1033 KWLDSDLAYEPSFSTVRLLLLDFFTKLMRFEGVRDMGITAFELSERLLADS-LSMCQID--DTLY 1094

  Fly  1306 AKEVNLVLFKSYYLLTHEVSVDPGFQACYEALLEQITPVIERLDYSFVYSFCKSNSNITLDHLCN 1370
            ..|:.......|..|:..||.:.      |.:.|....:.|.|......:|.:..:|    .:..
Yeast  1095 LLELRSSCLNLYETLSQGVSKNG------EEISEYGDEIQENLIELMFLNFNQERNN----QVST 1149

  Fly  1371 FLFKQLYSVQHSVRLSAVHSLRQLTPHFVADDIEL--NEKQSESLDASTTICKWHFLNRFEDYLT 1433
            ..:::||.|..|:.|..:.|..:.....|.:|.::  |..||..|   ||:.....:...:|.:.
Yeast  1150 LFYQKLYKVISSMELKKLESQYKRIFEVVLNDKDIGSNINQSRLL---TTLLGSLVVKTQQDIII 1211

  Fly  1434 RYDALI------------------------TKYLEEFTFKLSELDDLEPIDRHNALSYLFLWDCI 1474
            .|:..|                        .|.|::.|.::.: :.||..::::.:.||:.|..|
Yeast  1212 EYELRIQKQTGSDVDGSASDNDVNSKFKLPQKLLQKVTDEVPK-EYLEYENKNSFIKYLWYWHLI 1275

  Fly  1475 INACAKSPVALRAVYTNWLNDNKYEENFLHFL-----------FRAMPVDILKNHGAKVHSNGVY 1528
            :.....:...:|.::...|.:.........|:           ::.:....:..:....::...|
Yeast  1276 LMYFKDTSYNMRQIFIEQLKEAGLINRMFDFITDQIDLRDTEFWKQVDTKEISEYNIVGNNFSPY 1340

  Fly  1529 KELTWSQQKDRHLPLERYACHLYTEVLRKLPAVVRRWW-NATQSRQKNFIDNLTTNYVSSLICSE 1592
            ||..:.:.|       :...|...::...:..:...|| |......:|.|:...:.::|.::...
Yeast  1341 KEDIFEECK-------KLLGHTLYQLFNNVGCLTSIWWLNIKDRTLQNDIEKFVSEFISPILIKN 1398

  Fly  1593 ELKAIANRKEK----HENMQVTVHSSTREVLAVYAIDEARMELVITLAPNYPLGAVKVECGKQIG 1653
            |...|.::.::    .:.:.:.:::.|.||.|.|.||:.::|:...|..||||..::|....::|
Yeast  1399 EFDDINSKMDRLTSNDDALTIKLNNITNEVKASYLIDDQKLEISFKLPKNYPLTNIQVNGVSRVG 1463

  Fly  1654 -GRASSRNVGMQLTIFLTHQNGTIYDGLTMWKNNLDKKFEGVEECYVCYTVIHQETCQLPKLTCK 1717
             .....:...|.....:|..||::.|.|.::..|:..:|.|.|||.:||:::|....:||..||.
Yeast  1464 ISEQKWKQWIMSTQHVITGMNGSVLDSLELFTKNVHLQFSGFEECAICYSILHAVDRKLPSKTCP 1528

  Fly  1718 TCKKKFHGPCLYKWFTTSSKSTCPICRN 1745
            |||.||||.||||||.:|..:|||:||:
Yeast  1529 TCKNKFHGACLYKWFRSSGNNTCPLCRS 1556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ltn1	NP_730427.1	RING	<1724..1744	CDD:302633	12/19 (63%)
RKR1	NP_013975.1	COG5219	1..1561	CDD:227544	352/1913 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345828
Domainoid	1	1.000	114	1.000	Domainoid score	I1336
eggNOG	1	0.900	-	-		E1_COG5219
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I932
Isobase	1	0.950	-	0	Normalized mean entropy	S6253
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004053
OrthoInspector	1	1.000	-	-		oto99671
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12389
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R672
SonicParanoid	1	1.000	-	-		X2799
TreeFam	0	0.000	Not matched by this tool.
	11	10.960