DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14086 and TMEM72

DIOPT Version :9

Sequence 1:	NP_649102.3	Gene:	CG14086 / 40100	FlyBaseID:	FBgn0036860	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	NP_001116848.1	Gene:	TMEM72 / 643236	HGNCID:	31658	Length:	275	Species:	Homo sapiens

Alignment Length:	173	Identity:	41/173 - (23%)
Similarity:	69/173 - (39%)	Gaps:	23/173 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RVFGLLTSFVICGVGVDVYMHGYRAGL--YIVFSAVLVMFIEIKWLVTIFLQL--QCAEDNYQ-- 92
            |:.|:.|:.|:.|||.:.::.|....|  |::|:...|...|..:.|...|.:  ||...:..
Human    15 RLLGITTAAVLIGVGTETFLQGQFKSLAFYLLFTGAAVSICEGAYFVAQLLAICFQCQPGSLADR 79

  Fly    93 -RRSCSCLACWRLSAICGGWRPTPVYAVIGICLILYPHNLWLSYVAGMFLILLGL--LRLCTLLR 154
             |.....|.|::...         .|.::.:...|:|..:|...:.|..||:.||  ..|....:
Human    80 VREKAHWLGCFQKFL---------AYLLLSVACFLHPVLVWHVTIPGSMLIITGLAYFLLSKRKK 135

  Fly   155 FSASKEEGLLPQCDFEKVSSFVDT-----MEDDFAEIGATQAG 192
            ..|:.|....|:...:..||.|.|     .|..:...||.:.|
Human   136 RKAAPEVLASPEQYTDPSSSAVSTTGSGDTEQTYTFHGALKEG 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14086	NP_649102.3	TMEM72	29..>138	CDD:292672	24/110 (22%)
TMEM72	NP_001116848.1	TMEM72	4..189	CDD:318306	41/173 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..163		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..262
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1128211at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR28474
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.110