DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14085 and 2210408I21Rik

DIOPT Version :9

Sequence 1:	NP_649101.2	Gene:	CG14085 / 40099	FlyBaseID:	FBgn0036859	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	XP_036014072.1	Gene:	2210408I21Rik / 72371	MGIID:	1919621	Length:	1290	Species:	Mus musculus

Alignment Length:	887	Identity:	176/887 - (19%)
Similarity:	314/887 - (35%)	Gaps:	259/887 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PSGLLHTEKEMNE--GDFSSVTVKTSD-----------------PDKFVQLVTKSADLLLEHIHR 117
            |.|.:..|:|..:  ..|.|..::..|                 .:..|:..:|.|..:||.:..
Mouse   469 PEGHIFPEEEQPKRVAKFCSDIIEKLDTMLLLALACRDDSPQEIKENLVEAYSKVATAVLERLQE 533

  Fly   118 LSQESLDHADLSVLTATIGAASLVKNSLSVYMQAATTTICPPKGDEKGGALKLSFKQYSQMSEAL 182
            ..:|....|.|..|.:.:.:|:.|....:.|......|...|       ...:..::|.:....:
Mouse   534 RGKEVPSRAPLKNLHSILSSATYVSQRFTHYDNLMKETTKKP-------IFLVPVQRYQEFINTV 591

  Fly   183 AERLLDLHCRLLLLYIMQDADCLHWEDTQPFFESERGSYTVQMWWHYMRGSQTDLWNSVPPKMAQ 247
            ..::.|...|:..:.|:|||:..||:|.:.|:|.||.|:.:|||.::......|||..:|||:||
Mouse   592 QFQVTDYCARVCAMSILQDAESHHWDDYKAFYEGERCSFAIQMWHYFSLALHHDLWTILPPKLAQ 656

  Fly   248 KIFAGMLNETLSVLTVRYTQIVTSVARSTLHLVDICNMLLCIAELLPHICESGEAYVGLQLSNQS 312
            :|.|.||.::|.:|..||.:...|..|:....:|:..:|:....:|..||.||:..:.....|..
Mouse   657 EILAEMLEKSLGLLASRYARAHPSPKRTAQIRLDVMAILIFTENMLWSICSSGQEILNPHKFNNH 721

  Fly   313 VIIRDIHAKCKELFYCLLLRGSPLGVLSKVFRKGLDNMEMFSSRHGL------PSAWIIFALPRY 371
            .|.: ||..|..||..|.:..|||..|.|.|:.|:|.    |..:.|      |..| |..:.::
Mouse   722 KIFK-IHTHCNNLFTTLAILTSPLTELYKTFQHGVDE----SPSNSLTPLFNQPLHW-ISCMSQF 780

  Fly   372 FP---KEQSCQWVTEFSDLSTNTAISLDLRVLLAFPEADWSYLLKILLMRDAYLTGIIMR----- 428
            :|   :..|...:|...          .|::||:.|...|:.||..||.....:..|:::
Mouse   781 YPSLLRPPSVGGLTAQG----------QLKLLLSQPCCKWNLLLDTLLHSGGLIPRILLKSSKQA 835

  Fly   429 ------------------------HLMQYLPSSENFKNVAKISFTSAEGAPQKCEAFLCRGECFN 469
                                    ||     ||:.|.||    |.|.....|..: ||     ||
Mouse   836 AGMESKQSAGGSLVGAIFEVLYHCHL-----SSQTFGNV----FMSHMEEEQLWD-FL-----FN 885

  Fly   470 VTDSIAGDIDPVG---QSNYQIVLSLTYLVV-----AVGKAVDIKSCLIKTLEEHAIAGWSDCLD 526
            :         ||.   :|..:::..|...::     .|.:.:.|..|. :..|.:.
Mouse   886 I---------PVSSFTESQPEVIHCLRLALMDSVKDTVQQIISIMRCR-RNSETNL--------- 931

  Fly   527 KRQVWNQKRTPWLEAIMHFMYPVLDCVVDMLVNAVENGASMY------------------QAMSL 573
                 |:.|.|                 |.|:.::..|.:..                  ||:|:
Mouse   932 -----NKPRVP-----------------DHLLQSIPQGWNYIPRDSRGKESNKGITELAAQAVSI 974

  Fly   574 ALTCVSEIWDCLPEGLYKIASLLQDIIPVSTRPLGDSVLLQVVFAALYTELIKTAEMYEQAKDLD 638
            .|:.:..:..|||..:.....|.:..:..:...|..:.||      ::..:|....::|....::
Mouse   975 VLSKLPTVIACLPPTIKYFFFLSERKMSKNLAELKKAGLL------VWNLIIIICRIFEDGNTVE 1033

  Fly   639 K--------------AAICYSISEAICSIDEDDKHTDQIELFLKQAK-----------ESINLDT 678
            :              ..||..:...:.......:.|.::.|.:::.|           .::::..
Mouse  1034 RLTGSSLDRWSKEKLGLICLCLESILGKQSNPSQLTQKVILSIERQKPNWMEQQLLKARTLSIQC 1098

  Fly   679 DFGGTAGSNNRGAGGMSAVSTIKMDDLALTNAESDRLSHSPPNNYAMELDVGIADYIAEVLVSDV 743
            .|  |....|.|:.|.:|:...:..    |||....|.|.|.
Mouse  1099 AF--TRMEENSGSEGEAALELTEQK----TNAMVLDLCHKPG----------------------- 1134

  Fly   744 LTTNIGKQALKVVYNYLKFNKDWLLEQLGTGDNDPSPFQGIQGQNIKEAKTSVLRSM-------- 800
                 |.:.|:.:|:.::.|:::|.|||             ...|..|.|..::|.:
Mouse  1135 -----GSKYLQQIYHIMQLNEEYLKEQL-------------FAMNGSEEKPLLIRPLKVALRDED 1181

  Fly   801 -----------FFIGNTPFDQLLTGSLKIDYVSWLQMPLSLN 831
                       ..:..:..||:.|.:...|:.:.|...|.||
Mouse  1182 QPPAFNPFHVHKVVSESMLDQVATVTWCCDWSNLLPNYLGLN 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14085	NP_649101.2	DUF4495	99..430	CDD:291567	91/368 (25%)
2210408I21Rik	XP_036014072.1	DUF4495	515..832	CDD:405576	91/339 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5541
eggNOG	1	0.900	-	-		E1_2CA28
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007466
OrthoInspector	1	1.000	-	-		oto94769
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR33960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5691
SonicParanoid	1	1.000	-	-		X6341
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.900