DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14085 and RGD1560883

DIOPT Version :9

Sequence 1:	NP_649101.2	Gene:	CG14085 / 40099	FlyBaseID:	FBgn0036859	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	XP_017446642.1	Gene:	RGD1560883 / 294603	RGDID:	1560883	Length:	1303	Species:	Rattus norvegicus

Alignment Length:	854	Identity:	181/854 - (21%)
Similarity:	310/854 - (36%)	Gaps:	201/854 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VQLVTKSADLLLEHIHRLSQESLDHADLSVLTATIGAASLVKNSLSVYMQAATTTICPPKGDEKG 165
            |:...|.|..:||.:.....|....|.|..|...:.:|..:......|......|...|
  Rat   547 VEACCKVATAVLERLRERGTEVPSRAPLKNLHIILSSAVYISQWFMHYDNLMKETAKKP------ 605

  Fly   166 GALKLSFKQYSQMSEALAERLLDLHCRLLLLYIMQDADCLHWEDTQPFFESERGSYTVQMWWHYM 230
             ...:..::|.:....:..:|.|...|:....|:|||:..||||.:.|:|.||.|:.:|||.::.
  Rat   606 -IFLVPVQRYQEFISTVQFQLTDYCIRVCATSILQDAESHHWEDYKAFYEGERCSFAIQMWHYFS 669

  Fly   231 RGSQTDLWNSVPPKMAQKIFAGMLNETLSVLTVRYTQIVTSVARSTLHLVDICNMLLCIAELLPH 295
            .....|||..:|||:||:|.|.:|.::|.:|..||.:...|..|:....:||..:|:|..::|..
  Rat   670 WALHHDLWTILPPKLAQEILAELLEKSLGLLASRYARAHPSPRRTAQIRLDITAILICTEKMLWS 734

  Fly   296 ICESGEAYVGLQLSNQSVIIRDIHAKCKELFYCLLLRGSPLGVLSKVFRKGLDN--MEMFSSRHG 358
            :|.|.:..:.....|...|.: ||..|..||..|.:..|||..|.|.|:.|.|.  ...|:....
  Rat   735 VCTSEQEILNPHKYNHHKIFK-IHIHCNNLFTTLAILTSPLTELYKTFQDGRDESASNAFTPLFN 798

  Fly   359 LPSAWIIFALPRYFPKEQSCQWVTEF--SDLSTNTAISL----DLRVLLAFPEADWSYLLKILLM 417
            .|..||            ||  :::|  |.|...:|..|    .|::||:.|....:.||:.||.
  Rat   799 QPLHWI------------SC--LSQFHPSLLRPPSARELTAQGQLKLLLSQPCCKGNLLLETLLH 849

  Fly   418 RDAYLTGIIMRHLMQ-------------------------YLPSSENFKNVAKISFTSAEGAPQK 457
            .|..:..|:::...|                         :| |.:.|.||    |||.....|.
  Rat   850 GDGLIARILLKSAKQAAGMESKQSAGCSVVGTIFEVLYWCHL-SPQTFGNV----FTSHMEEEQL 909

  Fly   458 CEAFLCRGECFNVTDSIAGDIDPVGQSNYQIVLSLTYLVV-----AVGKAVDIKSCLIKTLEEHA 517
            .: |||     |:..|...:..|      :::..|...::     .|.:.:.:..|
  Rat   910 WD-FLC-----NIPVSAFTESQP------EVIRCLRLALIDSVKDTVQQIISMVKC--------- 953

  Fly   518 IAGWSDC---LDKRQV-----------WN--QKRTPWLEAIMHFMYPVLDCVVDMLVNAVENGAS 566
               |.:.   |:|..|           ||  .:.:.|.|:...|.                  ..
  Rat   954 ---WRNSETKLNKPPVPDHLLQSIPREWNYIPRDSTWKESNKGFT------------------RL 997

  Fly   567 MYQAMSLALTCVSEIWDCLPEGLYKIASLLQDIIPVSTRPLGDSVLLQVVFAALYTELIKTAEMY 631
            ..||:|:.|:.:..:..|||..:.....|.:..:..:...|..:.||......:...:.:.....
  Rat   998 AAQAVSIVLSKLPTVIACLPPTIKYFFFLSERKMSKNVAELKKAGLLVWNLIVIICRIFEDGNTV 1062

  Fly   632 EQ--AKDLDK------AAICYSISEAICSIDEDDKHTDQIELFLKQAK-----------ESINLD 677
            |:  ...||:      ..||..:...:.......:.|.::.|.::|..           .::|::
  Rat  1063 ERLTGSSLDRWSKEKLGLICLCLESILGEQSSPSQLTQKVILHIEQQSPNWIEHQLLKARTLNIE 1127

  Fly   678 TDFGGTAGSNNRGAGGMSAVSTIKMDDLALTNAESDRLSHSPPNNYAMELDVGIADYIAEVLVSD 742
                 .|.....|:.|....:.:::.: ..|||....|.|.|.
  Rat  1128 -----CASMPVEGSSGSEGDAVLELTE-QKTNAMVLDLCHKPG---------------------- 1164

  Fly   743 VLTTNIGKQALKVVYNYLKFNKDWLLEQL---GTGDNDPSPFQGIQGQNIKEAKTSVLRSMFF-- 802
                  |.:.|:.:|:.::.|:::|.|||   ...:..|.|.     |.:|||    ||:..:
  Rat  1165 ------GSKYLQQIYHIMQLNEEYLKEQLLAMNGSEEKPFPI-----QPLKEA----LRNGEYQP 1214

  Fly   803 -----------IGNTPFDQLLTGSLKIDYVSWLQMPLSLNPERTCLHLNRRCDFQEDAKLSLPEV 856
                       ...:..||..|.:...|:.:.|...|.|:.......|..|.:.::|..|...|.
  Rat  1215 PAFDPFHVHKVFSESMLDQAATATWYWDWSNLLPNYLGLDKMTFGPLLKNRWEMRKDETLEKNEK 1279

  Fly   857 AMVAGITKI 865
            .|:..:.:|
  Rat  1280 MMLEHLKQI 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14085	NP_649101.2	DUF4495	99..430	CDD:291567	94/336 (28%)
RGD1560883	XP_017446642.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5742
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007466
OrthoInspector	1	1.000	-	-		oto98272
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR33960
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6341
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.010