Protein Alignment CG14085 and KIAA0825

DIOPT Version :9

• Sequence 1: NP_649101.2
• Gene: CG14085 / 40099
• FlyBaseID: FBgn0036859
• Length: 874
• Species: Drosophila melanogaster
• Sequence 2: XP_011541626.1
• Gene: KIAA0825 / 285600
• HGNCID: 28532
• Length: 1341
• Species: Homo sapiens
• Alignment Length: 844
• Identity: 186/844 - (22%)
• Similarity: 320/844 - (37%)
• Gaps: 228/844 - (27%)

  Fly    61 WEDEY-FASYRKPSGLLHTEKEMNEGDFSSVTVKTSD----------PDKF-------VQLVTKS 107
            |:|.: |....:|..:         |.|.|..::..|          .|.|       |:...|.
Human   468 WQDSHMFPEEEQPKKI---------GKFCSDIMEKLDTMLPLALACRDDSFQEIRANLVEACCKV 523

  Fly   108 ADLLLEHIHRLSQESLDHADLSVLTATIGAASLVKNSLSVY---MQAATTTICPPKGDEKGGALK 169
            |..:|:.:...::|....|.|..|...:..|..|......|   |:..|          |.....
Human   524 ATAVLQRLQERAKEVPSKAPLKNLHTYLSTAVYVFQHFKRYDNLMKEMT----------KKPIFL 578

  Fly   170 LSFKQYSQMSEALAERLLDLHCRLLLLYIMQDADCLHWEDTQPFFESERGSYTVQMWWHYMRGSQ 234
            :..::|.:....|..::.:...|:....|:|||:..||:|.:.|:|.||.|:::|||.::.....
Human   579 VLVQRYQEFINTLQFQVTNYCVRVCATSILQDAESHHWDDYKAFYEGERCSFSIQMWHYFCWSLH 643

  Fly   235 TDLWNSVPPKMAQKIFAGMLNETLSVLTVRYTQIVTSVARSTLHLVDICNMLLCIAELLPHICES 299
            .|||..:|||:||:|...:|.::||:|..||.:...|..|:....:|:..:|:|...:|..:|.|
Human   644 YDLWTILPPKLAQEILVEVLEKSLSLLASRYARAHPSRKRTPQLRLDVTTILICTENMLWSVCTS 708

  Fly   300 GEAYVGLQLSNQSVIIRDIHAKCKELFYCLLLRGSPLGVLSKVFRKGLDNMEMFSSRHGLPSAWI 364
            .:..:.........|.: ||..|..||..|::..|||..|.|.|:.|||.    |:...|.|
Human   709 VQKLLNPHQHTDDKIFK-IHTHCNNLFTTLVILTSPLTELYKTFQHGLDE----SASDSLKS--- 765

  Fly   365 IFALPRYFPKEQSCQWVTEF--SDLSTNTAISL----DLRVLLAFPEADWSYLLKILLMRDAYLT 423
            .|..|.|:   .||  ::.|  |.|.|.:|..|    .|::||:.|..:|:.||:.||..|..|.
Human   766 FFKQPLYW---VSC--ISHFYPSLLRTPSAGGLKAEGQLKLLLSQPRCNWNLLLETLLHHDGLLL 825

  Fly   424 GIIM----RHLMQYLPSSEN------------FKNVAKISFTSAEGAPQK-CEAFLCRGECFNVT 471
            .|::    |...:.:..:||            ||.:...||     :||. ...|:...|...:.
Human   826 RILLKSSKRTFQEQVSDTENNLNQGPSLMEAIFKILYHCSF-----SPQTFANVFVSYMEEEQLW 885

  Fly   472 DSIAGDIDPVGQSNYQIVLSLTYLVVAVGKAVDIKSCL-------IKTLEEHAIAGWSDCLDKRQ 529
            |.:           |.|.:|     ..|...:::..||       ||...:..::
Human   886 DFL-----------YNIPVS-----TCVEYELEVIRCLRLALTDAIKDTVQQIVS---------- 924

  Fly   530 VWNQKRTPWLEAIMHFMYPVLDCVVDML----------VNAVENGASM----YQAMSLALTCVSE 580
            |.:.:|........|.   |.||:::.:          .|..|:..|.    .||:|:.::.:..
Human   925 VMSSRRNCETNLNKHI---VPDCLLESMPKEWNYSPKETNRKESCKSFTRLTAQAVSIVISKLPT 986

  Fly   581 IWDCLPEGLYKIASLLQDIIPVSTRPLGDSVLLQVVFAALYTELIKTAEMYEQAKDLDKAA-ICY 644
            :..|||.             ||.                 |...:...:|.::..:|.||. :.:
Human   987 VIACLPP-------------PVK-----------------YFFFLSERKMSKKFVELKKAGLLVW 1021

  Fly   645 SISEAICSIDEDDKHTDQIELFL-----KQAKESINLDTDFGGTAGSNNRGAGGMSAVSTIKMDD 704
            ::...||.|.||.   :.:||..     :.:||.:.|.                ...:.:|..|.
Human  1022 NLIVIICRIFEDG---NTVELLTGASLDRWSKEKLGLI----------------CMCLKSIMGDQ 1067

  Fly   705 LALTNAESDRLSHS----PPNNYAMEL------------------------DVG--IADYIAEVL 739
            .::.|....::..|    .||....:|                        ||.  :.:.....:
Human  1068 TSIHNQMIQKVIQSIEQQKPNWIERQLLKARKLSTECAFMTIEKSTALQEGDVALELTEQKINTM 1132

  Fly   740 VSDVLTTNIGKQALKVVYNYLKFNKDWLLEQL---GTGDNDPSPFQGIQGQNIKEAKTSVLRSM 800
            |.|:.....|::.|:.:|:.::.|:::|.|||   .:.:..|.|        |:..||: |||:
Human  1133 VLDLCHKPGGREYLRQIYHIMQLNEEYLKEQLFSMNSSEEKPLP--------IRPLKTT-LRSI 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14085	NP_649101.2	DUF4495	99..430	CDD:291567	99/350 (28%)
KIAA0825	XP_011541626.1	DUF4495	515..832	CDD:291567	97/339 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5680
eggNOG	1	0.900	-	-		E1_2CA28
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007466
OrthoInspector	1	1.000	-	-		oto91186
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR33960
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5691
SonicParanoid	1	1.000	-	-		X6341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	8.030