DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14085 and kiaa0825

DIOPT Version :9

Sequence 1:	NP_649101.2	Gene:	CG14085 / 40099	FlyBaseID:	FBgn0036859	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	XP_002933482.3	Gene:	kiaa0825 / 100498255	XenbaseID:	XB-GENE-877130	Length:	1260	Species:	Xenopus tropicalis

Alignment Length:	879	Identity:	177/879 - (20%)
Similarity:	330/879 - (37%)	Gaps:	228/879 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DFSSVTVKTSDPDKFVQLVTKSADLLLEHIHRLSQESLDHADLSVLTATIGAASLVKNSLSVYMQ 150
            |.|.:.|:..    |::..:|.|.|:|..:....:|....|.|..:.||:..|..|.:.|:.|..
Frog   500 DVSLLDVRAC----FLEAFSKVAALILAKLEEHHKEFPCKASLQSMYATLSTAIYVLHHLNYYSV 560

  Fly   151 AATTTICPPKGDEKGGALKLSFKQYSQMSEALAERLLDLHCRLLLLYIMQDADCLHWEDTQPFFE 215
            ..:          |.....::.::|.:....|...::.....:....|.|||:..:|:|.:.|:|
Frog   561 QMS----------KKSLFLVAVQRYQEFINNLQADVIQYCISVCSTSIFQDAESHNWDDNKEFYE 615

  Fly   216 SERGSYTVQMWWHYMRGSQTDLWNSVPPKMAQKIFAGMLNETLSVLTVRYTQIVTSVARSTLHLV 280
            .||.|:::|||.::..|.:.|||..:||.:||.||..::.:||::||.||:|:..:..|.:...|
Frog   616 GERCSFSIQMWHYFCCGLRHDLWTILPPLLAQDIFKEVVEQTLALLTFRYSQVHPNYKRVSQIRV 680

  Fly   281 DICNMLLCIAELLPHICESGEAYVGLQLSNQSVIIRDIHAKCKELFYCLLLRGSPLGVLSKVFRK 345
            ||..:..|:..:|..:|.|.:..:..........:: ||..|..|...:.:..:||..|.|...|
Frog   681 DIMAIFSCVENMLWSVCNSTQDLMRPTSQANGTTLK-IHNYCNSLLPVMAVLSTPLETLHKAITK 744

  Fly   346 GLDNMEMFSSR--HGLPSAWIIFALPRYFPKEQSCQWVTEFSDLSTNTAISL----DLRVLLAFP 404
            .|.......|:  |.:|..|||:..|.          :..||. .|.:|:.:    .|::||:.|
Frog   745 ELSGFPSSPSKQPHSVPLEWIIYLKPE----------LVLFSS-KTPSAVEMAVQGQLKLLLSQP 798

  Fly   405 EADWSYLLKILLMRDAYLTGIIMRHLMQYLPSSENFKNVAKISFTSAEGAPQKCEAFLCRGECFN 469
            ..:|:.||:.||..|..:...:.         :.:...:||.:...:|..|  |.|
Frog   799 CCNWNLLLETLLHSDCLVAKTLF---------ACSINEIAKRNHEDSESNP--CLA--------- 843

  Fly   470 VTDSIAGDIDPVGQSNYQIVLSLTYLVVAVGKAVDIKSCLIKTLEEHAIAGWSDCLDKRQVWNQK 534
                             :::||:........|.:.|      .:|.:        :|:.::|:
Frog   844 -----------------EMILSVLSYCTLTPKLLSI------VVENY--------MDQEKLWD-- 875

  Fly   535 RTPWLEAIMHFMYPVLDC------VVDMLVNAVENGASMYQAMSLALTCVSEIWDCLPEGLYK-- 591
                      |:..:..|      |:..|.|.::...........:|....|:.:|....:||
Frog   876 ----------FLCSITGCRAFVPYVIRYLKNTLKKSVLGIVKQVTSLIVSRELMECPNSCMYKYS 930

  Fly   592 IASLLQDIIPVS-----------------TRPLGDSVLLQV-----VFAAL-------------- 620
            |...|.|::|..                 |:.:.::|.:.:     |.|.:
Frog   931 IPETLLDVVPEKWKLTSRKTNIKASKKGLTKLIAEAVSIVIGRLPSVIACVPSPIKYLYSLAERK 995

  Fly   621 ----YTELIKT-----------AEMYEQAKDLDKA---AICYSISEAICSIDE-----------D 656
                |:|.|||           .|:......::.|   |:.....|.:.::.|           |
Frog   996 VSKKYSESIKTGILVLNLIDIICEVLHDGNTIENATGHALSTWCKENLTAVSECLQRVTGNKTND 1060

  Fly   657 DKHTDQ-------------IE-LFLKQAKESINLDTDFGGTAGSNNRGAGGMSAVSTIKMDDLAL 707
            :|...|             || .|||....|||                    :.|.::.|...|
Frog  1061 NKEATQKVFDFIGEKRPKWIENQFLKANSLSIN--------------------SGSAMQEDSSVL 1105

  Fly   708 TNAESDRLSHSPPNNYAMELDVGIADYIAEVLVSDVLTTNIGKQALKVVYNYLKFNKDWLLEQLG 772
            .:.:|             ||:  :.:....::|.|:.....|.:.|:.:|:.::.|:|:|..:..
Frog  1106 KDQDS-------------ELE--LTEQRINMMVLDICHKPGGSKYLRQIYHIIQLNEDYLNAEFS 1155

  Fly   773 TGDND-----PSPFQ-GIQGQNIKEAKTSVLRSMFFIGNTPFDQLLTGSLKIDYVSWLQMPLSLN 831
            |.:.|     ...|| .:.|...:.::.:.|.|...    |...:|:.....|:.|.|...|:::
Frog  1156 TQEPDKISAHSRNFQFNLTGGEDQLSRFNPLHSFIL----PASDVLSEHSTTDWHSLLSCCLAVH 1216

  Fly   832 PERTCLHLNRRCDFQEDAKLSLPEVAMVAGITKI 865
            |......|.||.: .:|..:|..|..::|.:.::
Frog  1217 PLTFQALLERRWE-TKDENISEEEKMLLAQLKQM 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14085	NP_649101.2	DUF4495	99..430	CDD:291567	87/336 (26%)
kiaa0825	XP_002933482.3	DUF4495	510..824	CDD:405576	87/344 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5528
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007466
OrthoInspector	1	1.000	-	-		oto104968
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910