Protein Alignment Aldh7A1 and ALDH4A1

DIOPT Version :10

• Sequence 1: NP_649099.1
• Gene: Aldh7A1 / 40097
• FlyBaseID: FBgn0036857
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_003739.2
• Gene: ALDH4A1 / 8659
• HGNCID: 406
• Length: 563
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 120/490 - (24%)
• Similarity: 198/490 - (40%)
• Gaps: 97/490 - (19%)

  Fly    72 GQPIAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELR--KYKEPLGKLVSLEV 134
            |..:||....:...|...|..|:.|.|:|...|...|.:|..:..|.|.  :..|.|.|.:   |
Human    88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTM---V 149

  Fly   135 GKIYSEGQGEVQEFIDICD-------YAVGL-------------SRIYSGQLINSERADHSILEA 179
            |:..:..|.|:....::.|       |||.|             |.:|.|            ||
Human   150 GQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRG------------LE- 201

  Fly   180 WRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP- 243
                |.|..||.:|| .|:.|..|......||.||||.:.:..|.|.|    |..:||...|||
Human   202 ----GFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYA----VYRILREAGLPPN 257

  Fly   244 -VVTLCQGGTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRR------FGKVILELGGNNALI 301
             :..:...|...|.|:.:.:.:..::||||..|.:.:..:|.:.      |.::..|.||.|...
Human   258 IIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHF 322

  Fly   302 IDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQT 366
            :..||:|:..:...|.......||:|:...|:.|...|..|....|:.::.::  |:|...|
Human   323 VHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRI--KVGDPAE--- 382

  Fly   367 LVGPVHTQQNVENYKAAIAEAKSLGG--------------TVAFGGNVIQRDGFYVEPTVITGLP 417
                     :...:.:|:.:|||...              |:..||......|::|||.::....
Human   383 ---------DFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKD 438

  Fly   418 HDASVVHRETFAPI--VYIL---KAKNVDQAIEWNNEVEQGLSSAIFTEN---IGQAFKWIGAKG 474
            ....::..|.|.|:  ||:.   |.|...|.::  :....||:.|:|:::   :.:|.|.:   .
Human   439 PQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVL---R 498

  Fly   475 SDCGIVNINTTTNGAEIG-GAFGGEKATGGGRESG 508
            :..|...||..:.|:.:| ..|||.:|:|...:.|
Human   499 NAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	120/490 (24%)
ALDH4A1	NP_003739.2	ALDH_F4-17_P5CDH	32..553	CDD:143441	120/490 (24%)