Protein Alignment Aldh7A1 and ALDH9A1

DIOPT Version :10

• Sequence 1: NP_649099.1
• Gene: Aldh7A1 / 40097
• FlyBaseID: FBgn0036857
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_000687.3
• Gene: ALDH9A1 / 223
• HGNCID: 412
• Length: 518
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 145/519 - (27%)
• Similarity: 244/519 - (47%)
• Gaps: 30/519 - (5%)

  Fly    13 LPRRLVTQTASYSSSSSYLIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVTSYDPGTGQPIAK 77
            |.|.|.....:..|:.::::.||    |...|..|..|...||       :..:::|.||:.||.
Human    13 LLRSLRPSPVAAMSTGTFVVSQP----LNYRGGARVEPADASG-------TEKAFEPATGRVIAT 66

  Fly    78 VRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGKIYSEGQ 142
            ......:|:...:..|..|:|.|.|.....|..|:.:....:|:.::.:..:..:..||...|.:
Human    67 FTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEAR 131

  Fly   143 GEVQEFIDICDYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYNFPNAVFGWNAAIAL 207
            .::.......:|..||:...:|:.|............ .||||...|.|:|:|..:..|.:|.||
Human   132 LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRR-EPLGVCVGIGAWNYPFQIASWKSAPAL 195

  Fly   208 TTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQGGTDVGQTLVADKRVNLVSFTG 271
            ..||::::|.:|.||:.::    ::||:.....:|| :..:.|||...||.|.....|..|||||
Human   196 ACGNAMVFKPSPFTPVSAL----LLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTG 256

  Fly   272 SCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVH 336
            |..||..:.....:....|.|||||.:.|||....::..|:..||.....|.||.|....|:.|.
Human   257 SVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQ 321

  Fly   337 EKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVI 401
            :::.|:|.:|:|.:.:::  |||..|...|.:||:..:.::|.....:..||..|..|..||::.
Human   322 KEILDKFTEEVVKQTQRI--KIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 384

  Fly   402 ------QRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEVEQGLSSAIFT 460
                  .:||:|:.|.|:|....|.:.|..|.|.|::.||......:.:|..|:...||::.:||
Human   385 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 449

  Fly   461 ENIGQAFKWIG-AKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAWKQYCKRATITV 523
            .:|.:|.:.:. .:...|.|.|.|.:.  .|:  .|||.|.:|.|||:|....:.|.:..|:.|
Human   450 RDIQRAHRVVAELQAGTCFINNYNVSP--VEL--PFGGYKKSGFGRENGRVTIEYYSQLKTVCV 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	135/481 (28%)
ALDH9A1	NP_000687.3	ALDH_F9_TMBADH	55..512	CDD:143409	133/466 (29%)