Protein Alignment Aldh7A1 and Aldh1a1

DIOPT Version :10

• Sequence 1: NP_649099.1
• Gene: Aldh7A1 / 40097
• FlyBaseID: FBgn0036857
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_038495.2
• Gene: Aldh1a1 / 11668
• MGIID: 1353450
• Length: 501
• Species: Mus musculus
• Alignment Length: 489
• Identity: 140/489 - (28%)
• Similarity: 230/489 - (47%)
• Gaps: 33/489 - (6%)

  Fly    54 SGQWQG--RGPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYK---QWRQVPAPVRGEIVR 113
            :.:|..  .|......:|.|.:.|..|.:|:..:::..:..|.:|::   .||.:.|..||.::.
Mouse    26 NNEWHNSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLN 90

  Fly   114 QIGDELRKYKEPLGKLVSLEVGKIYSEGQ-GEVQEFIDICDYAVGLSRIYSGQLINSERADHSIL 177
            ::.|.:.:.:..|..:.:|..||:::... .::...|....|..|.:....||.|.|   |..|.
Mouse    91 KLADLMERDRLLLATMEALNGGKVFANAYLSDLGGCIKALKYCAGWADKIHGQTIPS---DGDIF 152

  Fly   178 EAWR--PLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNN 240
            ...|  |:||.|.|..:|||..:|.|....||:.||:|:.|.|..|||    |...:|.:::...
Mouse   153 TYTRREPIGVCGQIIPWNFPMLMFIWKIGPALSCGNTVVVKPAEQTPL----TALHLASLIKEAG 213

  Fly   241 LPP-VVTLCQG-GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGK-----VILELGGNN 298
            .|| ||.:..| |...|..:.:...|:.|:||||.|    ||..::...||     |.|||||.:
Mouse   214 FPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQ----VGKLIKEAAGKSNLKRVTLELGGKS 274

  Fly   299 ALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLE 363
            ..|:...|::.:|::.|..|.....||.|....||.|.|.::|:|||..|.:.|:.:  :|:.|.
Mouse   275 PCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVKRSVERAKKYV--LGNPLT 337

  Fly   364 AQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETF 428
            .....||...::..:.....|...|..|..:..||......||:|:|||.:.:..:..:...|.|
Mouse   338 PGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIF 402

  Fly   429 APIVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINT-TTNGAEIG 492
            .|:..|:|.|:||..|:..|....||::.:||:::.:|.....|  ...|:|.:|. ....|:.
Mouse   403 GPVQQIMKFKSVDDVIKRANNTTYGLAAGLFTKDLDKAITVSSA--LQAGVVWVNCYMMLSAQC- 464

  Fly   493 GAFGGEKATGGGRESGSDAWKQYCKRATITVNHS 526
             .|||.|.:|.|||.|.....:|.:..|:.:..|
Mouse   465 -PFGGFKMSGNGRELGEHGLYEYTELKTVAMKIS 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	139/487 (29%)
Aldh1a1	NP_038495.2	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	139/485 (29%)
		Mediates interaction with PRMT3. /evidence=ECO:0000250|UniProtKB:P00352	336..501		46/166 (28%)