DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rept and RVB1

DIOPT Version :9

Sequence 1:	NP_001262040.1	Gene:	rept / 40092	FlyBaseID:	FBgn0040075	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_010476.1	Gene:	RVB1 / 851771	SGDID:	S000002598	Length:	463	Species:	Saccharomyces cerevisiae

Alignment Length:	439	Identity:	192/439 - (43%)
Similarity:	285/439 - (64%)	Gaps:	15/439 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IERIGAHSHIRGLGLDDVLEARLVSQGMVGQKDARRAAGVVVQMVREGKIAGRCILLAGEPSTGK 79
            :.|..||:||:|||||:...|:.|..|.|||.:||.|.||:|.:::..|::||.|||||.|||||
Yeast    21 VTRTAAHTHIKGLGLDESGVAKRVEGGFVGQIEAREACGVIVDLIKAKKMSGRAILLAGGPSTGK 85

  Fly    80 TAIAVGMAQALGTETPFTSMSGSEIYSLEMSKTEALSQALRKSIGVRIKEETEIIEGEVVEI--- 141
            ||:|:.::|.||.:.||..:.|||:||:|:.|||.|.:..|::||:||||..|:.||||.|:
Yeast    86 TALALAISQELGPKVPFCPLVGSELYSVEVKKTETLMENFRRAIGLRIKETKEVYEGEVTELTPE 150

  Fly   142 QIERPASGTGQKVGKVT--LKTTEMETNYDLGNKIIECFMKEKIQAGDVITIDKASGKVNKLGRS 204
            ..|.|..|.|:.:..|.  ||:.:......|...|.|...:||:..||||.|:..:|.|.::|||
Yeast   151 DAENPLGGYGKTISHVIVGLKSAKGTKTLRLDPTIYESIQREKVSIGDVIYIEANTGAVKRVGRS 215

  Fly   205 FTRARDYDATGAQTRFVQCPEGELQKRKEVVHTVTLHEIDVINSRTHG-------FLALFSGDTG 262
            ...|.::|....:  :|..|:||:.|:||:|..||||::||.|:|..|       ...|......
Yeast   216 DAYATEFDLETEE--YVPLPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDVISMMGQLLKPKKT 278

  Fly   263 EIKQEVRDQINNKVLEWREEGKAEINPGVLFIDEVHMLDIECFSFLNRALESDMAPVVVMATNRG 327
            ||.:::|.::|..|.::.::|.||:.|||||||||:|||||.|::||:||||::|||||:|:|||
Yeast   279 EITEKLRQEVNKVVAKYIDQGVAELIPGVLFIDEVNMLDIEIFTYLNKALESNIAPVVVLASNRG 343

  Fly   328 ITRIRGT-NYRSPHGIPIDLLDRMIIIRTVPYSEKEVKEILKIRCEEEDCIMHPDALTILTRIAT 391
            :|.:||| :..||||:|.||:||::|:||:||.:.|::.|::.|...|...:...||.:|..:.|
Yeast   344 MTTVRGTEDVISPHGVPPDLIDRLLIVRTLPYDKDEIRTIIERRATVERLQVESSALDLLATMGT 408

  Fly   392 DTSLRYAIQLITTANLVCRRRKATEVNTEDVKKVYSLFLDENRSSKILK 440
            :||||||:||:....::.:.....|:...||.:...||||..||:|||:
Yeast   409 ETSLRYALQLLAPCGILAQTSNRKEIVVNDVNEAKLLFLDAKRSTKILE 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rept	NP_001262040.1	TIP49	17..408	CDD:283678	180/403 (45%)
		P-loop_NTPase	69..>113	CDD:304359	25/43 (58%)
		AAA	<267..358	CDD:99707	52/91 (57%)
RVB1	NP_010476.1	TIP49	4..463	CDD:224145	192/439 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1224
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810