DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rept and ruvbl2

DIOPT Version :9

Sequence 1:	NP_001262040.1	Gene:	rept / 40092	FlyBaseID:	FBgn0040075	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	XP_012821814.1	Gene:	ruvbl2 / 448144	XenbaseID:	XB-GENE-483344	Length:	462	Species:	Xenopus tropicalis

Alignment Length:	451	Identity:	356/451 - (78%)
Similarity:	411/451 - (91%)	Gaps:	0/451 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAETEKIEVRDVTRIERIGAHSHIRGLGLDDVLEARLVSQGMVGQKDARRAAGVVVQMVREGKIA 65
            ||.|:..||||||||||||||||||||||||.||.|.||||||||..|||||||:::|::|||||
Frog     4 MATTKVPEVRDVTRIERIGAHSHIRGLGLDDALEPRQVSQGMVGQLAARRAAGVILEMIKEGKIA 68

  Fly    66 GRCILLAGEPSTGKTAIAVGMAQALGTETPFTSMSGSEIYSLEMSKTEALSQALRKSIGVRIKEE 130
            ||.:|:||:|.|||||||:|||||||::||||:::||||:||||||||||:||.|:|||||||||
Frog    69 GRAVLIAGQPGTGKTAIAMGMAQALGSDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEE 133

  Fly   131 TEIIEGEVVEIQIERPASGTGQKVGKVTLKTTEMETNYDLGNKIIECFMKEKIQAGDVITIDKAS 195
            ||||||||||:||:|||:|||.||||:|||||||||.||||.|:||...|||:|||||||||||:
Frog   134 TEIIEGEVVEVQIDRPATGTGAKVGKLTLKTTEMETIYDLGTKMIESLTKEKVQAGDVITIDKAT 198

  Fly   196 GKVNKLGRSFTRARDYDATGAQTRFVQCPEGELQKRKEVVHTVTLHEIDVINSRTHGFLALFSGD 260
            ||:.||||:|||||||||.|:||:|||||:|||||||||||||:|||||||||||.|||||||||
Frog   199 GKITKLGRAFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGD 263

  Fly   261 TGEIKQEVRDQINNKVLEWREEGKAEINPGVLFIDEVHMLDIECFSFLNRALESDMAPVVVMATN 325
            |||||.|||:|||.||.||||||||||.|||||||||||||||||||||||||||||||::||||
Frog   264 TGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIECFSFLNRALESDMAPVLIMATN 328

  Fly   326 RGITRIRGTNYRSPHGIPIDLLDRMIIIRTVPYSEKEVKEILKIRCEEEDCIMHPDALTILTRIA 390
            |||||||||||:||||||||||||::||.|.||:|||.|:||||||||||..|..||.|:||||.
Frog   329 RGITRIRGTNYQSPHGIPIDLLDRLLIISTSPYNEKETKQILKIRCEEEDVDMTEDAYTVLTRIG 393

  Fly   391 TDTSLRYAIQLITTANLVCRRRKATEVNTEDVKKVYSLFLDENRSSKILKEYQDDYMFSEI 451
            .:|||||::||||.|:||||:||.|||..:|:|:||||||||:||::.:|||||.:||:|:
Frog   394 LETSLRYSMQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQDAFMFNEM 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rept	NP_001262040.1	TIP49	17..408	CDD:283678	315/390 (81%)
		P-loop_NTPase	69..>113	CDD:304359	32/43 (74%)
		AAA	<267..358	CDD:99707	79/90 (88%)
ruvbl2	XP_012821814.1	TIP49	14..450	CDD:224145	347/435 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	576	1.000	Domainoid score	I222
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4856
Inparanoid	1	1.050	716	1.000	Inparanoid score	I626
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D273414at33208
OrthoFinder	1	1.000	-	-		FOG0004276
OrthoInspector	1	1.000	-	-		oto103919
Panther	1	1.100	-	-	LDO	PTHR11093
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1272
SonicParanoid	1	1.000	-	-		X3010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190