DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rept and AgaP_AGAP009746

DIOPT Version :9

Sequence 1:	NP_001262040.1	Gene:	rept / 40092	FlyBaseID:	FBgn0040075	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	XP_318830.2	Gene:	AgaP_AGAP009746 / 1279153	VectorBaseID:	AGAP009746	Length:	469	Species:	Anopheles gambiae

Alignment Length:	470	Identity:	405/470 - (86%)
Similarity:	441/470 - (93%)	Gaps:	5/470 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAETEKIEVRDVTRIERIGAHSHIRGLGLDDVLEARLVSQGMVGQKDARRAAGVVVQMVREGKIA 65
            |.:.||||:|||||||||||||||||||||||||||.|||||||||:||||||:|||||||||||
Mosquito     1 MTDLEKIEIRDVTRIERIGAHSHIRGLGLDDVLEARTVSQGMVGQKEARRAAGIVVQMVREGKIA 65

  Fly    66 GRCILLAGEPSTGKTAIAVGMAQALGTETPFTSMSGSEIYSLEMSKTEALSQALRKSIGVRIKEE 130
            ||||||||||||||||||||||||||.|||||||||||||||||:||||||||||||||:|||||
Mosquito    66 GRCILLAGEPSTGKTAIAVGMAQALGNETPFTSMSGSEIYSLEMNKTEALSQALRKSIGLRIKEE 130

  Fly   131 TEIIEGEVVEIQIERPASGTGQKVGKVTLKTTEMETNYDLGNKIIECFMKEKIQAGDVITIDKAS 195
            |||||||||||||:|||:||||||||||:|||:|||||||||||||||:||||||||:|||||||
Mosquito   131 TEIIEGEVVEIQIDRPATGTGQKVGKVTMKTTDMETNYDLGNKIIECFIKEKIQAGDIITIDKAS 195

  Fly   196 GKVNKLGRSFTRARDYDATGAQTRFVQCPEGELQKRKEVVHTVTLHEIDVINSRTHGFLALFSGD 260
            |||:||||||||||||||||:||||||||||||||||||||||:|||||||||||||||||||||
Mosquito   196 GKVSKLGRSFTRARDYDATGSQTRFVQCPEGELQKRKEVVHTVSLHEIDVINSRTHGFLALFSGD 260

  Fly   261 TGEIKQEVRDQINNKVLEWREEGKAEINPGVLFIDEVHMLDIECFSFLNRALESDMAPVVVMATN 325
            |||||||||||||:||:|||||||||||||||||||.||||||||||||||||||||||||||||
Mosquito   261 TGEIKQEVRDQINSKVIEWREEGKAEINPGVLFIDECHMLDIECFSFLNRALESDMAPVVVMATN 325

  Fly   326 RGITRIRGTNYRSPHGIPIDLLDRMIIIRTVPYSEKEVKEILKIRCEEEDCIMHPDALTILTRIA 390
            ||||:||||:|||||||||||||||||||||||:|||:|||||||||||||.::.|||.:|.|||
Mosquito   326 RGITKIRGTHYRSPHGIPIDLLDRMIIIRTVPYTEKEIKEILKIRCEEEDCQINNDALMVLGRIA 390

  Fly   391 TDTSLRYAIQLITTANLVCRRRKATEVNTEDVKKVYSLFLDENRSSKILKEYQDDYMFSEITEEV 455
            |:||||||||.||||:||.:||||.|:..||::|||||||||.|||||||||||:|:|.:
Mosquito   391 TETSLRYAIQSITTASLVSKRRKAAEIMVEDIRKVYSLFLDEKRSSKILKEYQDEYLFYD----- 450

  Fly   456 ERDPAAGGGAKRRVE 470
            :..|.|.|...:.:|
Mosquito   451 DSLPKAEGQQAQAME 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rept	NP_001262040.1	TIP49	17..408	CDD:283678	358/390 (92%)
		P-loop_NTPase	69..>113	CDD:304359	41/43 (95%)
		AAA	<267..358	CDD:99707	85/90 (94%)
AgaP_AGAP009746	XP_318830.2	TIP49	17..408	CDD:283678	358/390 (92%)
AgaP_AGAP009746	XP_318830.2	P-loop_NTPase	69..>104	CDD:304359	33/34 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	644	1.000	Domainoid score	I575
eggNOG	1	0.900	-	-		E1_COG1224
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4856
Inparanoid	1	1.050	799	1.000	Inparanoid score	I1438
OMA	1	1.010	-	-		QHG53744
OrthoDB	1	1.010	-	-		D273414at33208
OrthoFinder	1	1.000	-	-		FOG0004276
OrthoInspector	1	1.000	-	-		oto108732
Panther	1	1.100	-	-	LDO	PTHR11093
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3010
TreeFam	1	0.960	-	-
	13	12.940