DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gem2 and GEMIN2

DIOPT Version :9

Sequence 1:	NP_001262034.1	Gene:	Gem2 / 40087	FlyBaseID:	FBgn0036850	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_003607.2	Gene:	GEMIN2 / 8487	HGNCID:	10884	Length:	269	Species:	Homo sapiens

Alignment Length:	261	Identity:	76/261 - (29%)
Similarity:	113/261 - (43%)	Gaps:	38/261 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QLQALEICEPDSSFDPQKPPESGEEYLMHMFYERKRCPAVVTKR--SSKI-RNNTGNTTLEMLDN 72
            :|..:|.|:....|||..||.:.:|||..:..|..:||.||..:  ..|: |..:.|.:|....
Human    16 RLLPVEPCDLTEGFDPSVPPRTPQEYLRRVQIEAAQCPDVVVAQIDPKKLKRKQSVNISLSGCQ- 79

  Fly    73 PELPPFKCLLPTPEWRDEQVKSFQAARSQVLVLRKELANNNYDQSGEPPLTSDQEKWKEFCRNQQ 137
               |..:...||.:|:.:||..|...|..|...|....:...|.:...|.:.|:|.||:||..::
Human    80 ---PAPEGYSPTLQWQQQQVAQFSTVRQNVNKHRSHWKSQQLDSNVTMPKSEDEEGWKKFCLGEK 141

  Fly   138 -------------------------PLLSTLLHLTQNDLELLLEMLSKWLQDPNTTVDLLHDVWL 177
                                     ||||.:..:.|..:..:||.||.|..:.:.|.:      |
Human   142 LCADGAVGPATNESPGIDYVQIGFPPLLSIVSRMNQATVTSVLEYLSNWFGERDFTPE------L 200

  Fly   178 ARWLYATLVCLHLPLEPHVFSTLRYIARTCIHLRNQLKEDEVQRAAPYNLLLTLTVQVFAQNDFK 242
            .|||||.|.||..||.|...|.:|.:||.|..:|..:...:.:|....|||:.|..:.|.|.|..
Human   201 GRWLYALLACLEKPLLPEAHSLIRQLARRCSEVRLLVDSKDDERVPALNLLICLVSRYFDQRDLA 265

  Fly   243 D 243
            |
Human   266 D 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gem2	NP_001262034.1	SIP1	18..239	CDD:282754	71/248 (29%)
GEMIN2	NP_003607.2	SIP1	34..262	CDD:398549	67/237 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160466
Domainoid	1	1.000	101	1.000	Domainoid score	I6969
eggNOG	1	0.900	-	-		E1_28H7D
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37827
Inparanoid	1	1.050	110	1.000	Inparanoid score	I4895
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55374
OrthoDB	1	1.010	-	-		D1235594at2759
OrthoFinder	1	1.000	-	-		FOG0005780
OrthoInspector	1	1.000	-	-		oto89573
orthoMCL	1	0.900	-	-		OOG6_104791
Panther	1	1.100	-	-	LDO	PTHR12794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4058
SonicParanoid	1	1.000	-	-		X6261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800