Protein Alignment SmydA-2 and Smyd3

DIOPT Version :10

• Sequence 1: NP_649084.1
• Gene: SmydA-2 / 40075
• FlyBaseID: FBgn0036839
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_081464.1
• Gene: Smyd3 / 69726
• MGIID: 1916976
• Length: 428
• Species: Mus musculus
• Alignment Length: 458
• Identity: 106/458 - (23%)
• Similarity: 173/458 - (37%)
• Gaps: 150/458 - (32%)

  Fly    58 GRHLRATRDIKIGEQILKEAPLVLGPKVASAPLCLG-----CHRNLLAPGKPRGNYHKCSSCS-W 116
            |..|||...::.||.:.:..||       :..:|.|     |.|.||  ||.:  ..:||.|. .
Mouse    15 GNGLRAVAPLRPGELLFRSDPL-------AYTVCKGSRGVVCDRCLL--GKEK--LMRCSQCRIA 68

  Fly   117 PLCGKECEDSV--HHKAECQLMSGSNFQSKINYVPGEEERKESAYCVIMLLR-CMHLKDKDPDAF 178
            ..|..:|:...  .|:.||..:.    ..|..|.|..         |.:|.| .:.|.|:.|...
Mouse    69 KYCSAKCQKKAWPDHRRECSCLK----SCKPRYPPDS---------VRLLGRVIVKLMDEKPSES 120

  Fly   179 LKL---YNLEDHLKERLETPLYQVLRANLITF-------IKTVLGMKDWPEMDILRIAAILDTNT 233
            .||   |:||.:: .:|.....:.||...:||       |:....:.  |..|:....|.:..|:
Mouse   121 EKLYSFYDLESNI-SKLTEDKKEGLRQLAMTFQHFMREEIQDASQLP--PSFDLFEAFAKVICNS 182

  Fly   234 FEVRQPRERRKIRALYPGAAMISHDCVPNMRHRFDDDMNIVFLAKRKIAKGEILSISYTQPLRST 298
            |.:.....:.....|||..::::|.|.||....|:.. :::..|.|:|..||.|:|.|...|.::
Mouse   183 FTICNAEMQEVGVGLYPSMSLLNHSCDPNCSIVFNGP-HLLLRAVREIEAGEELTICYLDMLMTS 246

  Fly   299 IQRRVHLRQAKCFDCSCARCQDPEELGSFAGAQTCLKCKAGKIISLNPLLNSAPWKCQLCNFKRS 363
            .:||..||...||:|.|.|||..::
Mouse   247 EERRKQLRDQYCFECDCIRCQTQDK---------------------------------------- 271

  Fly   364 AKDVVTSDAELQQEL-ESLDKTTPVALEEFIYRHRADLHETNTHILQAKYALTQLYGSAPGFAME 427
            ..|::|.|.::.:|: |||.|     :||                |:|.:...|:
Mouse   272 DADMLTGDEQIWKEVQESLKK-----IEE----------------LKAHWKWEQV---------- 305

  Fly   428 ELSGESLNRKLQLCEELL-----KLADIFDGGWSIFRGNLL---ID-------MEEALVTQALRS 477
                      |.||:.::     :|.||     :|::..:|   :|       :||||. .|:|:
Mouse   306 ----------LALCQAIINSNSNRLPDI-----NIYQLKVLDCAMDACINLGMLEEALF-YAMRT 354

  Fly   478 KDP 480
            .:|
Mouse   355 MEP 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:460312
		SET_SMYD	<227..318	CDD:380997	28/90 (31%)
Smyd3	NP_081464.1	SET_SMYD3	5..268	CDD:380980	76/280 (27%)
		zf-MYND	49..87	CDD:460312	12/41 (29%)
		C-terminal domain, essential for histone methyltransferase activity, nuclear localization and mediates interaction with HSP90AA1. /evidence=ECO:0000250|UniProtKB:Q9H7B4	272..428		29/133 (22%)