DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SmydA-2 and SMYD3

DIOPT Version :10

Sequence 1:NP_649084.1 Gene:SmydA-2 / 40075 FlyBaseID:FBgn0036839 Length:530 Species:Drosophila melanogaster
Sequence 2:NP_001161212.1 Gene:SMYD3 / 64754 HGNCID:15513 Length:428 Species:Homo sapiens


Alignment Length:340 Identity:87/340 - (25%)
Similarity:141/340 - (41%) Gaps:60/340 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 GRHLRATRDIKIGEQILKEAPLVLGPKVASAPLCLG-----CHRNLLAPGKPRGNYHKCSSCS-W 116
            |..|||...::.||.:.:..||       :..:|.|     |.|.||  ||.:  ..:||.|. .
Human    15 GNGLRAVTPLRPGELLFRSDPL-------AYTVCKGSRGVVCDRCLL--GKEK--LMRCSQCRVA 68

  Fly   117 PLCGKECEDSV--HHKAECQLMSGSNFQSKINYVPGEEERKESAYCVIMLLRCM-HLKDKDPDAF 178
            ..|..:|:...  .||.||:.:.    ..|..|.|..         |.:|.|.: .|.|..|...
Human    69 KYCSAKCQKKAWPDHKRECKCLK----SCKPRYPPDS---------VRLLGRVVFKLMDGAPSES 120

  Fly   179 LKL---YNLEDHLKERLETPLYQVLRANLITF-------IKTVLGMKDWPEMDILRIAAILDTNT 233
            .||   |:||.:: .:|.....:.||..::||       |:....:.  |..|:....|.:..|:
Human   121 EKLYSFYDLESNI-NKLTEDKKEGLRQLVMTFQHFMREEIQDASQLP--PAFDLFEAFAKVICNS 182

  Fly   234 FEVRQPRERRKIRALYPGAAMISHDCVPNMRHRFDDDMNIVFLAKRKIAKGEILSISYTQPLRST 298
            |.:.....:.....|||..::::|.|.||....|:.. :::..|.|.|..||.|:|.|...|.::
Human   183 FTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGP-HLLLRAVRDIEVGEELTICYLDMLMTS 246

  Fly   299 IQRRVHLRQAKCFDCSCARCQ-DPEELGSFAGAQTCLKCKAGKIISLNPLLNSAPWKCQ----LC 358
            .:||..||...||:|.|.||| ..::.....|.:...|.....:..:..|  .|.||.:    :|
Human   247 EERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEEL--KAHWKWEQVLAMC 309

  Fly   359 NFKRSAKDVVTSDAE 373
                  :.:::|::|
Human   310 ------QAIISSNSE 318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmydA-2NP_649084.1 zf-MYND 9..46 CDD:460312
SET_SMYD <227..318 CDD:380997 28/90 (31%)
SMYD3NP_001161212.1 SET_SMYD3 5..268 CDD:380980 77/280 (28%)
zf-MYND 49..87 CDD:460312 13/41 (32%)
C-terminal domain, essential for histone methyltransferase activity, nuclear localization and mediates interaction with HSP90AA1. /evidence=ECO:0000269|PubMed:25738358 272..428 9/55 (16%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.