DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmydA-2 and Smyd4-4

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_610730.1	Gene:	Smyd4-4 / 36299	FlyBaseID:	FBgn0027495	Length:	573	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	104/461 - (22%)
Similarity:	157/461 - (34%)	Gaps:	147/461 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 CFEIATNEVLGRHLRATRDIKIGEQILKEAPLVLGPKVASAPL----CLGCHRNLLAPGKPRGNY 108
            |.|:......||.:...||:.:|:.:..|.|..   .....|:    |..|.|.         ||
  Fly   186 CLELRETAAEGRFVVTNRDLAVGDLVSVEEPFC---STLLTPMRYIRCATCKRE---------NY 238

  Fly   109 ---HKCSS-CSWPLCGKECED---SVHHKAECQLMSGSN--FQS-----------KINYVPGEEE 153
               ..|.| ||...|.:||:.   ..:|:.||.::...|  |..           .:|..|..||
  Fly   239 LTLIPCDSCCSTMFCSEECKSIAMQTYHRYECPIIDFLNRMFNKIHCIALRTTLVALNIFPSIEE 303

  Fly   154 RKESAYCVIMLLRCMHLKDKDPDAFLKLYN---LEDHLKE----------RLETPLYQ------V 199
                     ::..|...:::|..||...||   .|:|.:.          |..:.|:|      |
  Fly   304 ---------LIDFCEQEQNQDKCAFDLNYNELTPEEHYRAIHGLVTNQHLRSVSDLFQRSVVCAV 359

  Fly   200 LRANLITF--IKTVLGMKDWPEMDILRIAAILDTNTFE------VRQPRERRKIRALYPGA---- 252
            |:..:|.:  :|..||.::........:...|.|:...      |.|..|.:..:....||
  Fly   360 LKHFIIEYTPVKEYLGGEEGVNFFTDLLFRHLQTSPSNMHGIDLVEQVNETKDDQTHSSGAYAFL 424

  Fly   253 AMISHDCVPNMRHRFDDDMNIVFLAKRKIAKGEILSISYTQ--PLRSTIQRRVHLRQAKCFDCSC 315
            ::|:|.|.||....::.....:|:. |.|..|.:|..:|..  .:.|..||...|.....|||.|
  Fly   425 SLINHSCAPNTVRIYEGTKAYMFVL-RPIKAGNVLYDNYGAHFAICSKEQRLKRLSLQYRFDCKC 488

  Fly   316 ARCQDPEELGSFAGAQTCLKCKAGKIISLN-PLLNSAPWKCQLCNFKRSAKDVVTSDAELQQELE 379
            ..|:                        || |:....|.|..:.:        ||.|.||
  Fly   489 EGCE------------------------LNYPMFGMMPHKATVPS--------VTDDTEL----- 516

  Fly   380 SLDKTTPVALEEFIYRHRADLHETNTHILQAKYA--LTQLYGSAPGFAMEELSGESLNRKLQLCE 442
                    ||..:.|    |...:|    ..||.  ||| ||.  .:..|::|.         .|
  Fly   517 --------ALSSYNY----DFAVSN----YRKYCDFLTQ-YGD--DYPCEQISS---------AE 553

  Fly   443 ELLKLA 448
            |.||:|
  Fly   554 ECLKMA 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	12/48 (25%)
Smyd4-4	NP_610730.1	TPR_11	67..138	CDD:290150
		zf-MYND	230..270	CDD:280009	13/48 (27%)
		SET	363..463	CDD:279228	21/100 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810