DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-2 and set-18

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_871849.1	Gene:	set-18 / 172949	WormBaseID:	WBGene00044070	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	123/552 - (22%)
Similarity:	202/552 - (36%)	Gaps:	158/552 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IATNEVLGRHLRATRDIKIGEQILKEAPLVLGPKVASAPLCLGCHRNLLAPGKPRGNYHKCSSCS 115
            :..:|:...|.|    |||.|...  |..||.|||:.  .|..|.|. .|||:   ...:|..|:
Worm    17 VQKDEISSIHAR----IKIFETPF--ATQVLNPKVSE--FCANCLRG-PAPGE---KLLRCGGCN 69

  Fly   116 WPL-CGKECEDS--VHHKAECQLMSGS---------NFQSKI-----------NYVPGEEERKES 157
            :.: |.|||:.:  :.||.||:.:..|         .|.||:           :.:..|.|||.|
Worm    70 FSMYCSKECQATAWLVHKPECKRLKASFPNLPLTEVLFLSKVIDRIQFLEKNGDKLGIEAERKFS 134

  Fly   158 AYCVIMLLRCMHLKDKDPDAFLKLYNLEDHLKERLETPLYQVLRANLITFIKTVLGMKDWPEM-- 220
            :    ::...:.::|.:.    |:.:.|...::                     :|.....||
Worm   135 S----LVDHKVDIRDDEE----KMAHFEKIFEK---------------------MGAFRGEEMIE 170

  Fly   221 -----DILRIAAILDTNTFEVRQPRERRKIRALYPGAAMISHDCVPNMRHRFDDDMNIVFLAKRK 280
                 |:...|.|   |:..:..........||..|.:..:|.|.|.....||.    ..:..|.
Worm   171 KGEFFDVFCKATI---NSHSIHTNAGNEVGMALDLGVSKYNHSCRPTCSMVFDG----YRVCLRP 228

  Fly   281 IAKG------EILSISYTQPLRSTIQRRVHLRQAKCFDCSCARCQDPEELGSFAGAQTCLKCKAG 339
            :..|      |...|||....||...||..|.....|:|.|.||.|||:     .|.|.::|
Worm   229 LVPGVDAENTEEAFISYIDVGRSKYIRRRDLNSRWYFNCECTRCMDPED-----DALTAIRC--- 285

  Fly   340 KIISLNPL-------------LNSAPWKCQLC---NFKRSAKDVVTS-----DAELQQELESLDK 383
                .||.             :|.|..||:..   :..::|::.:.:     |.:...|:|:|
Worm   286 ----ANPACDAPILTSETEEPMNIACEKCKTIVEEDTVKAAQEYMKTLPASFDPKCPAEIEAL-- 344

  Fly   384 TTPVALEEFIYRHRADLHETNTHILQAKYALTQLYGSAPGFAMEELSG--ESLNRKLQLC----- 441
              |..|:|.:.:....||.:|.::.:.:.||..:.|:   ..|:.||.  ..:....::|
Worm   345 --PGKLKELLAKAEQILHPSNVYVARLRTALFHVTGT---LTMDNLSSMHTQIYNNYKMCFPKAD 404

  Fly   442 --------------------EELLKLADIFDGGWSIFRGNLLIDMEEALVTQALRSKDPLDCEEK 486
                                :|.:..|  || ..:||.....:|....|.|.||.:.    .|:|
Worm   405 RHVGFQLLHIVKALIEKDERDEAMPYA--FD-AMNIFEVCFGLDHPYYLQTLALWTY----LEKK 462

  Fly   487 LRNAAEMLREIRNIMKHEPEMQQLLLERQVIL 518
            :..:.|.|.::.|...:.|.....||:|..:|
Worm   463 IPKSTEELVQLTNFSDNRPIDIVSLLKRANML 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	12/50 (24%)
set-18	NP_871849.1	zf-MYND	49..90	CDD:366792	14/44 (32%)
set-18	NP_871849.1	SET	82..274	CDD:394802	47/227 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4564
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870