Protein Alignment SmydA-2 and set-18

DIOPT Version :10

• Sequence 1: NP_649084.1
• Gene: SmydA-2 / 40075
• FlyBaseID: FBgn0036839
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_871849.1
• Gene: set-18 / 172949
• WormBaseID: WBGene00044070
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 552
• Identity: 123/552 - (22%)
• Similarity: 202/552 - (36%)
• Gaps: 158/552 - (28%)

  Fly    51 IATNEVLGRHLRATRDIKIGEQILKEAPLVLGPKVASAPLCLGCHRNLLAPGKPRGNYHKCSSCS 115
            :..:|:...|.|    |||.|...  |..||.|||:.  .|..|.|. .|||:   ...:|..|:
 Worm    17 VQKDEISSIHAR----IKIFETPF--ATQVLNPKVSE--FCANCLRG-PAPGE---KLLRCGGCN 69

  Fly   116 WPL-CGKECEDS--VHHKAECQLMSGS---------NFQSKI-----------NYVPGEEERKES 157
            :.: |.|||:.:  :.||.||:.:..|         .|.||:           :.:..|.|||.|
 Worm    70 FSMYCSKECQATAWLVHKPECKRLKASFPNLPLTEVLFLSKVIDRIQFLEKNGDKLGIEAERKFS 134

  Fly   158 AYCVIMLLRCMHLKDKDPDAFLKLYNLEDHLKERLETPLYQVLRANLITFIKTVLGMKDWPEM-- 220
            :    ::...:.::|.:.    |:.:.|...::                     :|.....||
 Worm   135 S----LVDHKVDIRDDEE----KMAHFEKIFEK---------------------MGAFRGEEMIE 170

  Fly   221 -----DILRIAAILDTNTFEVRQPRERRKIRALYPGAAMISHDCVPNMRHRFDDDMNIVFLAKRK 280
                 |:...|.|   |:..:..........||..|.:..:|.|.|.....||.    ..:..|.
 Worm   171 KGEFFDVFCKATI---NSHSIHTNAGNEVGMALDLGVSKYNHSCRPTCSMVFDG----YRVCLRP 228

  Fly   281 IAKG------EILSISYTQPLRSTIQRRVHLRQAKCFDCSCARCQDPEELGSFAGAQTCLKCKAG 339
            :..|      |...|||....||...||..|.....|:|.|.||.|||:     .|.|.::|
 Worm   229 LVPGVDAENTEEAFISYIDVGRSKYIRRRDLNSRWYFNCECTRCMDPED-----DALTAIRC--- 285

  Fly   340 KIISLNPL-------------LNSAPWKCQLC---NFKRSAKDVVTS-----DAELQQELESLDK 383
                .||.             :|.|..||:..   :..::|::.:.:     |.:...|:|:|
 Worm   286 ----ANPACDAPILTSETEEPMNIACEKCKTIVEEDTVKAAQEYMKTLPASFDPKCPAEIEAL-- 344

  Fly   384 TTPVALEEFIYRHRADLHETNTHILQAKYALTQLYGSAPGFAMEELSG--ESLNRKLQLC----- 441
              |..|:|.:.:....||.:|.::.:.:.||..:.|:   ..|:.||.  ..:....::|
 Worm   345 --PGKLKELLAKAEQILHPSNVYVARLRTALFHVTGT---LTMDNLSSMHTQIYNNYKMCFPKAD 404

  Fly   442 --------------------EELLKLADIFDGGWSIFRGNLLIDMEEALVTQALRSKDPLDCEEK 486
                                :|.:..|  || ..:||.....:|....|.|.||.:.    .|:|
 Worm   405 RHVGFQLLHIVKALIEKDERDEAMPYA--FD-AMNIFEVCFGLDHPYYLQTLALWTY----LEKK 462

  Fly   487 LRNAAEMLREIRNIMKHEPEMQQLLLERQVIL 518
            :..:.|.|.::.|...:.|.....||:|..:|
 Worm   463 IPKSTEELVQLTNFSDNRPIDIVSLLKRANML 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:460312
		SET_SMYD	<227..318	CDD:380997	24/96 (25%)
set-18	NP_871849.1	zf-MYND	49..90	CDD:460312	14/44 (32%)
		SET	82..274	CDD:394802	47/227 (21%)