Protein Alignment SmydA-2 and Smyd1

DIOPT Version :8

• Sequence 1: NP_649084.1
• Gene: SmydA-2 / 40075
• FlyBaseID: FBgn0036839
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001153599.1
• Gene: Smyd1 / 12180
• MGIID: 104790
• Length: 490
• Species: Mus musculus
• Alignment Length: 530
• Identity: 115/530 - (21%)
• Similarity: 202/530 - (38%)
• Gaps: 110/530 - (20%)

  Fly    50 EIATNEVLGRHLRATRDIKIGEQILKEAPLVLGPKVASAPLCLGCHRNLLAPGKPRGNYHKCSSC 114
            |:.|:|..||.|:||::....:.|..|.  .....|..:.:...||...    |.:...|:|..|
Mouse    10 EVFTSEGKGRGLKATKEFWAADVIFAER--AYSAVVFDSLINFVCHTCF----KRQEKLHRCGQC 68

  Fly   115 SWP-LCGKECEDS--VHHKAECQLMSGSNFQSKINYVPGEEERKESAYCVIMLLRCMHLKDKD-- 174
            .:. .|.:.|:..  ::||.||..:      .|...||.|..|        :..|.|...:::
Mouse    69 KFAHYCDRTCQKDAWLNHKNECAAI------KKYGKVPNENIR--------LAARIMWRVEREGT 119

  Fly   175 ---PDAFLKLYNLEDHLKERLETPLYQVLRANLITFIKTVLGMKDWPEMD-------ILRIAAIL 229
               ....:.:.:|::|: |.......:.||.::.||::.      ||...       |..|..::
Mouse   120 GLTEGCLVSVDDLQNHV-EHFGEEEQKELRVDVDTFLQY------WPPQSQQFSMQYISHIFGVI 177

  Fly   230 DTNTFEVRQPRERRKIR-ALYPGAAMISHDCVPN------------MRHRFDDDMNIVFLAKRKI 281
            :.|.|.:...|..:.:. .::|...:::|||.||            ::..|...|.|...|..||
Mouse   178 NCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKI 242

  Fly   282 AKGEILSISYTQPLRSTIQRRVHLRQAKCFDCSCARCQDPEELGSFAGAQTCLKCKAGKIISLNP 346
            ::||.|::||...|..:.:||..|::...|||||..||...:...|..|:.            :|
Mouse   243 SEGEELTVSYIDFLHLSEERRRQLKKQYYFDCSCEHCQKGLKDDLFLAAKE------------DP 295

  Fly   347 LLNSAPWKCQLCNFKRSAKDVVTSDAELQQE-LESLDKTTPVAL--------EEFIYRHRADLHE 402
                           :.:::||....:..:: ||.:||.....|        .|.:.:......:
Mouse   296 ---------------KPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFAD 345

  Fly   403 TNTHILQ----AKYALT--QLYGSAPGFAMEELSG-----ESLNRKLQLCEELLKLADIFDGGWS 456
            ||.::|:    |...|:  |.|..|..:|...:.|     ...|.:|.:......|.:...|...
Mouse   346 TNLYVLRLLSIASEVLSYLQAYEEASHYARRMVDGYMKLYHHNNAQLGMAVMRAGLTNWHAGHIE 410

  Fly   457 IFRGNLLIDMEEALVTQALRSKDPLDCE-EKLRNAAEMLREIRNIMKHE---PEMQQLLLERQVI 517
            :..|.:.......|||..  ...|:..: |.:|...||  |:|...::|   .:|::..|..|.:
Mouse   411 VGHGMICKAYAILLVTHG--PSHPITKDLEAMRMQTEM--ELRMFRQNEFMYHKMREAALNNQPM 471

  Fly   518 LSSALERFEP 527
            ...|....||
Mouse   472 QVMAEPSNEP 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009
		SET	<246..291	CDD:214614	15/57 (26%)
Smyd1	NP_001153599.1	S-adenosyl-L-methionine binding	17..19		0/1 (0%)
		zf-MYND	52..90	CDD:280009	10/41 (24%)
		SET	<194..257	CDD:214614	17/62 (27%)