Protein Alignment Prp6 and PRP6

DIOPT Version :10

• Sequence 1: NP_649073.1
• Gene: Prp6 / 40064
• FlyBaseID: FBgn0036828
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_009611.1
• Gene: PRP6 / 852344
• SGDID: S000000259
• Length: 899
• Species: Saccharomyces cerevisiae
• Alignment Length: 978
• Identity: 272/978 - (27%)
• Similarity: 437/978 - (44%)
• Gaps: 153/978 - (15%)

  Fly    17 FLGVPAPLGYVAGVGRGATGFTTRSDIGPARDANDVSDDRHAPPATKRKKKDEEEEEDEDLNDSN 81
            ||....|.|||.|:|||||||:|       ::...||:|.......||.:        |:||:.
Yeast     6 FLDQEPPAGYVPGIGRGATGFST-------KEKQVVSNDDKGRRIPKRYR--------ENLNNH- 54

  Fly    82 YDEFSGYSGSLFSKDPYDKDDEEADAIYDSIDKRMDEKRKEYRDRRLREDLERYRQERPKIQQQF 146
                       ....|.|.:|:||..::.:::.::.:|:|    :|..|..:....:...:::||
Yeast    55 -----------LQSQPKDDEDDEAANVFKTLELKLAQKKK----KRANEKDDDNSVDSSNVKRQF 104

  Fly   147 SDLKRSLASVTSEEWSTIPEVGDSRNRKQRNPRAE----KFTPLPDSLISRNLGGESSSTLDPSS 207
            :|||.|||:||..||..||:..|...|.:||...|    |....|||||
Yeast   105 ADLKESLAAVTESEWMDIPDATDFTRRNKRNRIQEQLNRKTYAAPDSLI---------------- 153

  Fly   208 GLASMVPGVATPGMLTPTGDLDLRKIGQARNTLMNVKLSQVSDSVTGQT--------------VV 258
                             .|::||.|:.:.|..|:.   ||:.:::...|              ..
Yeast   154 -----------------PGNVDLNKLTEEREKLLQ---SQIDENLAQLTKNASNPIQVNKPNAAT 198

  Fly   259 DPKGYLTDLQS--MIPTYGGDINDIKKARLLLKSVRETNPNHPPAWIASARLEEVTGKVQMARNL 321
            |...||.||::  :.......:.|::|.|.:|||.|:.:|.:|..|||||||||...|..:|:.:
Yeast   199 DALSYLKDLENDRVNSLSDATLEDLQKMRTILKSYRKADPTNPQGWIASARLEEKARKFSVAKKI 263

  Fly   322 IMRGCEMNIQSEDLWLEAARLQPPDT--AKAVIAQAARHIPTSVRIWIKAADLESETKAKRRVFR 384
            |..||:...:|.|:|||..||...|.  .|.::|.|....|||..:|.||.||||.|..|.||.|
Yeast   264 IENGCQECPRSSDIWLENIRLHESDVHYCKTLVATAINFNPTSPLLWFKAIDLESTTVNKYRVVR 328

  Fly   385 KALEHIPNSVRLWKAAVELENPDDARI--LLSRAVECCNTSVELWLALARLETYENARKVLNKAR 447
            |||:.||....|||.||..| .|.|::  :|.:|.:....|::|..|...|::|.||:..||..|
Yeast   329 KALQEIPRDEGLWKLAVSFE-ADKAQVIKMLEKATQFIPQSMDLLTAYTNLQSYHNAKMTLNSFR 392

  Fly   448 ENIPTDRQIWTTAAKLEEANGNIHMVEKIID---RSLTSLTVNGVEINRDQWFQEAIEAEKSGAV 509
            :.:|.:.:||..:..|||.|.....|:|::.   ..|..|:.||.:.....|.:.|.....:...
Yeast   393 KILPQEPEIWIISTLLEERNNPDIPVDKLVSLLKEGLLELSKNGYKATLSAWLKRAEALNDAPNS 457

  Fly   510 N-CCQSIVKAVIGIGVEEEDRKQTWI-DDAEFCAKENAFECARAVYAHA-LQIFPSKKSI----- 566
            | .||:||.|::           .|: :..|:.::.|..:.......|: :||...||.|
Yeast   458 NLTCQAIVYAIL-----------EWLRESGEYESELNNVDQILEKMPHSKVQIAVLKKLIQWDPC 511

  Fly   567 ----WLRAAYFEKNHGTRESLEALLQRAVAHC-----------PKSEILWLMGAKSKWMA--GDV 614
                |.|.....:::...|.|.|..|..:...           .||..|.:|.....|.|  ||.
Yeast   512 DTVLWSRLKMATESYHKIEELLAFFQELLFQTKNSDDIRANMREKSPGLLMMYVSEYWKAQKGDT 576

  Fly   615 PAARGILSLAFQANPNSEDIWLAAVKLESENSEYERARRLLAKARGS------APTPRVMMKSAR 673
            .....::.......|::.|:....:||...:.:.:..|....:...|      :.|.|:..|...
Yeast   577 RQTLVLIDQIIDFAPHNLDLRFFKIKLLGRSLQLDELRDFFQQTFSSLEDFKISGTERLYYKYVN 641

  Fly   674 LEWALEKFDEALRLL-EEAVEVFPDFPKLWMMKGQIEEQQRRTDDAAATYTLGLKKCPTSIPLWI 737
            .....:..:||::.| |..::.||...|.::..|||.......:.:..||..|.:..|....||:
Yeast   642 FLRYQDLNEEAIKFLNERCLKSFPICHKFFLQLGQIYHSMGNIEMSRETYLSGTRLVPNCPLLWV 706

  Fly   738 LSANLEE---RKGVLTKARSILERGRLRNPKVAVLWLEAIRVELRAGLKEIASTMMARALQECPN 799
            ..:.::|   :..|  :|||||:||.|:||...:.::..|::|:|.|..:.|..::.:|||:.|:
Yeast   707 SLSKIDEIDLKNPV--RARSILDRGLLKNPDDVLFYIAKIQMEIRLGNLDQAELLVTQALQKFPS 769

  Fly   800 AGELWAEAIFM----ETKPQRKTKSVDALKKCEHDPHVLLAVSKLFWSEHKFSKCRDWFNRTVKI 860
            ...||.|.|.:    .....:||...|||::.::|..|||.:...|::|.::.....|..|.:|.
Yeast   770 NALLWVEQIKLFKHGNKSSLKKTIFQDALRRTQNDHRVLLEIGVSFYAEAQYETSLKWLERALKK 834

  Fly   861 DPDLGDAWAYFYK-FELLHGTEAQQQEVLDRCISAEPTHGESWCRVSKNIQNWQFKTP-EVLRAV 923
            ....||.|.:.:: :..|.........:.|:|   |||:|..|...|||:: .|:.|| |:|..:
Yeast   835 CSRYGDTWVWLFRTYARLGKDTVDLYNMFDQC---EPTYGPEWIAASKNVK-MQYCTPREILLRL 895

  Fly   924 VRE 926
            :.:
Yeast   896 MND 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp6	NP_649073.1	PRP1_N	22..173	CDD:461908	45/150 (30%)
		PEP_TPR_lipo	236..>800	CDD:274350	174/621 (28%)
		TPR repeat	393..419	CDD:276809	10/27 (37%)
		TPR repeat	424..448	CDD:276809	8/23 (35%)
		TPR repeat	454..481	CDD:276809	8/29 (28%)
		LapB	610..861	CDD:442196	67/266 (25%)
		TPR repeat	633..660	CDD:276809	4/26 (15%)
		TPR repeat	698..728	CDD:276809	7/29 (24%)
		TPR repeat	733..758	CDD:276809	9/27 (33%)
		TPR repeat	767..795	CDD:276809	6/27 (22%)
PRP6	NP_009611.1	PRP1_N	11..131	CDD:461908	45/150 (30%)
		COG5191	201..>370	CDD:227518	69/169 (41%)
		LapB	630..855	CDD:442196	62/226 (27%)
		TPR repeat	634..662	CDD:276809	6/27 (22%)
		TPR repeat	668..696	CDD:276809	7/27 (26%)
		TPR repeat	701..732	CDD:276809	11/32 (34%)
		TPR repeat	737..765	CDD:276809	6/27 (22%)
		TPR repeat	770..800	CDD:276809	9/29 (31%)
		TPR repeat	805..833	CDD:276809	7/27 (26%)