Protein Alignment Prp6 and Prpf6

DIOPT Version :10

• Sequence 1: NP_649073.1
• Gene: Prp6 / 40064
• FlyBaseID: FBgn0036828
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_001073234.1
• Gene: Prpf6 / 366276
• RGDID: 1307103
• Length: 941
• Species: Rattus norvegicus
• Alignment Length: 936
• Identity: 674/936 - (72%)
• Similarity: 792/936 - (84%)
• Gaps: 19/936 - (2%)

  Fly    11 NRNKKHFLGVPAPLGYVAGVGRGATGFTTRSDIGPARDANDVSDDRHAPPATK-----RKKKDEE 70
            |:.||.|||:|||||||.|:|||||||||||||||||||||..|||||||..:     .||....
  Rat     2 NKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKNQAA 66

  Fly    71 EEEDEDLNDSNYDEFSGYSGSLFSKDPYDKDDEEADAIYDSIDKRMDEKRKEYRDRRLREDLERY 135
            :::||||||:|||||:||:|||||..||:||||||||||.::||||||:|||.|::|.:|::|:|
  Rat    67 DDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKY 131

  Fly   136 RQERPKIQQQFSDLKRSLASVTSEEWSTIPEVGDSRNRKQRNPRAEKFTPLPDSLISRNL-GGES 199
            |.||||||||||||||.||.||.|||.:||||||:||::|||||.||.||:|||..:::| .||:
  Rat   132 RMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGEN 196

  Fly   200 SSTLDP------------SSGLASMVPGVATPGMLTP-TGDLDLRKIGQARNTLMNVKLSQVSDS 251
            .:::||            ..||.:..||..|||::|| ||:||:|||||||||||:::|||||||
  Rat   197 HTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDS 261

  Fly   252 VTGQTVVDPKGYLTDLQSMIPTYGGDINDIKKARLLLKSVRETNPNHPPAWIASARLEEVTGKVQ 316
            |:||||||||||||||.|||||:||||||||||||||||||||||:|||||||||||||||||:|
  Rat   262 VSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQ 326

  Fly   317 MARNLIMRGCEMNIQSEDLWLEAARLQPPDTAKAVIAQAARHIPTSVRIWIKAADLESETKAKRR 381
            :||||||:|.||..:|||:|||||||||.||||||:|||.||:|.||||:|:||:||::.:||:|
  Rat   327 VARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKR 391

  Fly   382 VFRKALEHIPNSVRLWKAAVELENPDDARILLSRAVECCNTSVELWLALARLETYENARKVLNKA 446
            |.||||||:||||||||||||||.|:||||:||||||||.|||||||||||||||||||||||||
  Rat   392 VLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKA 456

  Fly   447 RENIPTDRQIWTTAAKLEEANGNIHMVEKIIDRSLTSLTVNGVEINRDQWFQEAIEAEKSGAVNC 511
            ||||||||.||.|||||||||||..||||||||::|||..|||||||:||.|:|.|.:::|:|..
  Rat   457 RENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVAT 521

  Fly   512 CQSIVKAVIGIGVEEEDRKQTWIDDAEFCAKENAFECARAVYAHALQIFPSKKSIWLRAAYFEKN 576
            ||::::||||||:||||||.||::||:.|...||.|||||:||:|||:||||||:||||||||||
  Rat   522 CQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKN 586

  Fly   577 HGTRESLEALLQRAVAHCPKSEILWLMGAKSKWMAGDVPAARGILSLAFQANPNSEDIWLAAVKL 641
            ||||||||||||||||||||:|:||||||||||:||||||||.||:||||||||||:||||||||
  Rat   587 HGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKL 651

  Fly   642 ESENSEYERARRLLAKARGSAPTPRVMMKSARLEWALEKFDEALRLLEEAVEVFPDFPKLWMMKG 706
            ||||:|||||||||||||.||||.||.|||.:|||.|.....|..|.|||:..:.||||||||||
  Rat   652 ESENNEYERARRLLAKARSSAPTARVFMKSVKLEWVLGNITAAQELCEEALRHYEDFPKLWMMKG 716

  Fly   707 QIEEQQRRTDDAAATYTLGLKKCPTSIPLWILSANLEERKGVLTKARSILERGRLRNPKVAVLWL 771
            |||||....:.|...|..||||||.|.|||:|.:.|||:.|.||:||:|||:.||:|||...|||
  Rat   717 QIEEQGELMERAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWL 781

  Fly   772 EAIRVELRAGLKEIASTMMARALQECPNAGELWAEAIFMETKPQRKTKSVDALKKCEHDPHVLLA 836
            |::|:|.|||||.||:|:||:|||||||:|.||:||:|:|.:|||||||||||||||||||||||
  Rat   782 ESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAVFLEARPQRKTKSVDALKKCEHDPHVLLA 846

  Fly   837 VSKLFWSEHKFSKCRDWFNRTVKIDPDLGDAWAYFYKFELLHGTEAQQQEVLDRCISAEPTHGES 901
            |:||||||.|.:|.|:||:||||||.|||||||:||||||.||||.||:||..||.:|||.|||.
  Rat   847 VAKLFWSERKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCENAEPRHGEL 911

  Fly   902 WCRVSKNIQNWQFKTPEVLRAVVREL 927
            ||.|||:|.|||.|..|:|..|...:
  Rat   912 WCAVSKDITNWQRKIGEILVLVAARI 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp6	NP_649073.1	PRP1_N	22..173	CDD:461908	110/155 (71%)
		PEP_TPR_lipo	236..>800	CDD:274350	430/563 (76%)
		TPR repeat	393..419	CDD:276809	22/25 (88%)
		TPR repeat	424..448	CDD:276809	23/23 (100%)
		TPR repeat	454..481	CDD:276809	22/26 (85%)
		LapB	610..861	CDD:442196	176/250 (70%)
		TPR repeat	633..660	CDD:276809	24/26 (92%)
		TPR repeat	698..728	CDD:276809	18/29 (62%)
		TPR repeat	733..758	CDD:276809	14/24 (58%)
		TPR repeat	767..795	CDD:276809	17/27 (63%)
Prpf6	NP_001073234.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79		51/76 (67%)
		PRP1_N	13..169	CDD:461908	110/155 (71%)
		LapB	<289..456	CDD:442196	138/166 (83%)
		HAT 1	384..416		24/31 (77%)
		TPR repeat	405..428	CDD:276809	19/22 (86%)
		LapB	414..705	CDD:442196	226/290 (78%)
		HAT 2	418..444		23/25 (92%)
		TPR repeat	433..459	CDD:276809	25/25 (100%)
		HAT 3	445..476		28/30 (93%)
		TPR repeat	464..491	CDD:276809	22/26 (85%)
		HAT 4	554..586		26/31 (84%)
		HAT 5	588..620		29/31 (94%)
		HAT 6	622..654		28/31 (90%)
		TPR repeat	643..670	CDD:276809	24/26 (92%)
		LapB	654..899	CDD:442196	169/244 (69%)
		HAT 7	689..721		18/31 (58%)
		TPR repeat	708..738	CDD:276809	18/29 (62%)
		HAT 8	723..755		15/31 (48%)
		TPR repeat	743..768	CDD:276809	14/24 (58%)
		TPR repeat	777..805	CDD:276809	17/27 (63%)
		HAT 9	855..887		23/31 (74%)