DRSC/TRiP Functional Genomics Resources

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Protein Alignment: Atg3 and ATG3

Sequence 1:NP_649059.1 Gene:Atg3 FlyBaseID:FBgn0036813 Length:330 Species:Drosophila melanogaster
Sequence 2:NP_071933.2 Gene:ATG3 HGNCID:20962 Length:314 Species:Homo sapiens

Alignment Length:331 Identity:208/332 (63%)
Similarity:256/332 (77%) Gaps:19/332 (6%)


  Fly     1 MQSVLNTVKGTALNVAEYLTPVLKESKFRETGVLTPEEFVAAGDHLVHHCPTWQWAAGDETKTKP 65
            ||:|:|||||.||.||||||||||||||:||||:||||||||||||||||||||||.|:|.|.|.
Human     1 MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKA 65

  Fly    66 YLPKDKQFLITRNVPCYRRCKQMEYVGE-ETLVEEESGDGGWVETHQLNDDGTTQLEDKICELTM 129
            |||..||||:|:|||||:|||||||..| |.::||:.||||||:|:  ::.|.|.:.:.:.|:|:
Human    66 YLPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTY--HNTGITGITEAVKEITL 128

  Fly   130 EETKEEMHTPDSDKSAPGAGGQAEDEDDDEAIDMDDFEESGMLELVDPAVATTTRKPEPEAKASP 194
             |.|:.:...|......    :.||||:.||.||:::||||:|| .|.|...|.:         .
Human   129 -ENKDNIRLQDCSALCE----EEEDEDEGEAADMEEYEESGLLE-TDEATLDTRK---------I 178

  Fly   195 VAAASGDAEASG-DSVLHTRTYDLHISYDKYYQTPRLWVVGYDEQRKPLTVEQMYEDVSQDHAKK 258
            |.|.....:|.| |::|.||||||:|:|||||||||||:.||||||:|||||.||||:||||.||
Human   179 VEACKAKTDAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKK 243

  Fly   259 TVTMESHPHLPGPNMASVHPCRHADIMKKIIQTVEEGGGQLGVHLYLIIFLKFVQTVIPTIEYDF 323
            |||:|:|||||.|.|.||||||||::|||||:||.||||:||||:||:|||||||.||||||||:
Human   244 TVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDY 308

  Fly   324 TQNFNM 329
            |::|.|
Human   309 TRHFTM 314

Known Domains:


GeneSequenceDomainRegion External IDIdentity
Atg3NP_649059.1 Autophagy_N 8..135 CDD:281916 86/128 (67%)
Autophagy_act_C 219..280 CDD:281917 49/61 (80%)
Autophagy_C 301..325 CDD:287367 20/24 (83%)
ATG3NP_071933.2 Autophagy_N 8..135 CDD:309202 86/130 (66%)
Caspase cleavage motif LETD 166..169 2/4 (50%)
Autophagy_act_C 204..265 CDD:309203 49/61 (80%)
Autophagy_C 286..309 CDD:313582 19/23 (83%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 C163185255
eggNOG 1 0.900 E1_KOG2981
Hieranoid 1 1.000
Homologene 1 1.000 H6836
Inparanoid 1 1.050 425 1.000 Inparanoid score I1738
Isobase 00.000 Not matched by this tool.
OMA 1 1.010
OrthoDB 1 1.010 D1432328at2759
OrthoFinder 1 1.000 FOG0004324
OrthoInspector 1 1.000 T1074978
orthoMCL 1 0.900 OOG5_128240
Panther 1 1.100 LDO PTHR12866
Phylome 1 0.910 0.667 Consistency score
RoundUp 1 1.030 avgDist Average_Evolutionary_Distance R108
TreeFam 1 0.960
User_Submission 00.000 Not matched by this tool.
1413.800

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