DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nufip and Nufip1

DIOPT Version :9

Sequence 1:	NP_649058.1	Gene:	Nufip / 40043	FlyBaseID:	FBgn0036812	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001007759.1	Gene:	Nufip1 / 364430	RGDID:	1359440	Length:	486	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	128/506 - (25%)
Similarity:	190/506 - (37%)	Gaps:	175/506 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PNGSTTSNHLYLTPSGMTLLPRSKQPPPMYGARGSTVPAKY----LHQEQSSPVSVPASPPVYHS 79
            |||..|.|..:.:|:..:..|:|.              |.|    |.|.:... ......||:|.
  Rat   118 PNGFPTYNTSFHSPATHSYFPQSY--------------ANYNDFNLPQNRKQK-KKKRKEPVFHF 167

  Fly    80 PPRPEFCHTCVMELANSQDMKLHLEQHEFCPADDCDFAALHNILERHIESNHITGTYVKVKKVWS 144
                 ||.||.....|.:...:|:.:|:.||..||.|:|...|::.|..:.|..|  :|..|:.:
  Rat   168 -----FCDTCDRGFKNQEKYDIHMSEHKKCPEVDCSFSAHEKIVQFHWRNMHAPG--MKKIKLDT 225

  Fly   145 EEELAAWRAERRKKFPTAANVELARLAKEQRIKRGERLEASKSRFGNREDRQRTRGGPQGDH--- 206
            .|::|.||.||||.:||.||:|..:|.:.::.||||.|  :.:::|..:...|        |
  Rat   226 PEDIARWREERRKNYPTLANIERKKLLQLEKEKRGEVL--TTTQYGKMKGMSR--------HSQM 280

  Fly   207 -KVRFDPKNKKKRCAKGKANEKKKKRVGTDKANEALKQKETNEDKKEE---EVNLCSLGNAKFGG 267
             |:|...|:.|.:  .|.|.::....:|    |.|       .|.|.|   :||:..||..
  Rat   281 AKIRSPGKHYKWK--SGGARQRAVLGLG----NRA-------RDLKPEIPTKVNVDPLGVL---- 328

  Fly   268 TGQMPEYQHFKAKVQKKDNALSSFLGMYGSDSDEESEAESDDQNTADCSKQIPAQVESSQSMPSE 332
                                         ..||.||:.:...|...               :|.|
  Rat   329 -----------------------------IHSDSESDKDEKSQRAI---------------VPKE 349

  Fly   333 ITEMGPALEASNTPNSVDNTQTCEDFTPMLEMTSSDQVPREISNISQITTSNSEPAKEDGSSDEG 397
            :|   |||              |       .:.||      ..|:|             ||..|
  Rat   350 VT---PAL--------------C-------SLMSS------YGNVS-------------GSESE- 370

  Fly   398 PDEEPFQRVTETITASDPVKPPPEPMEPKPQTAPKRAAPKRIYGLNYKRAR--------KQ---- 450
            |:|.|.:...| :.|.:.|.|...|..|:...   |...:.:....:|..|        ||
  Rat   371 PEEAPIKTEAE-VLAENRVLPSSPPKSPRHNV---RTTARTVLRAKWKAQRSGLRKITLKQKKSP 431

  Fly   451 -----TPNT----MLSKLLESDIRHERNVLLQCVRHVCERNFFGI--GQAK 490
                 .|.|    :|..||..||||||||:|||||::.:::|||:  |..|
  Rat   432 CHPLFEPRTRHPHLLEMLLAPDIRHERNVILQCVRYIIKKDFFGLTAGSVK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nufip	NP_649058.1	NUFIP1	126..180	CDD:402194	21/53 (40%)
Nufip1	NP_001007759.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71
		NUFIP1	209..261	CDD:287432	21/53 (40%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	236..252		8/15 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353857
Domainoid	1	1.000	46	1.000	Domainoid score	I11815
eggNOG	1	0.900	-	-		E1_28HFB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5048
OMA	1	1.010	-	-		QHG49899
OrthoDB	1	1.010	-	-		D1394860at2759
OrthoFinder	1	1.000	-	-		FOG0006990
OrthoInspector	1	1.000	-	-		oto97951
orthoMCL	1	0.900	-	-		OOG6_106531
Panther	1	1.100	-	-	LDO	PTHR13309
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5881
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770