DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nufip and Nufip1

DIOPT Version :9

Sequence 1:	NP_649058.1	Gene:	Nufip / 40043	FlyBaseID:	FBgn0036812	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_038773.1	Gene:	Nufip1 / 27275	MGIID:	1351474	Length:	484	Species:	Mus musculus

Alignment Length:	485	Identity:	122/485 - (25%)
Similarity:	192/485 - (39%)	Gaps:	145/485 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PNGSTTSNHLYLTPSGMTLLPRSKQPPPMYGARGSTVPAKYLHQEQSSPVSVPASPPVYHSPPRP 83
            |||.:|.:..|.:|...:..|||..             ||:...:.....:.....||:|.
Mouse   118 PNGFSTYHTSYQSPVTHSYFPRSHD-------------AKFNLPQNRKQKTKKRKEPVFHF---- 165

  Fly    84 EFCHTCVMELANSQDMKLHLEQHEFCPADDCDFAALHNILERHIESNHITGTYVKVKKVWSEEEL 148
             ||.||.....|.:....|:.:|..||..||.|:|...|::.|..:.|..|  :|..|:.:.||:
Mouse   166 -FCDTCDRGFKNQEKYDTHMSEHTKCPEVDCSFSAHEKIVQFHWRNMHAPG--MKKIKLDTPEEI 227

  Fly   149 AAWRAERRKKFPTAANVELARLAKEQRIKRGERLEASKSRFGNREDRQRTRGGPQGDH----KVR 209
            |.||.||||.:||.||:|..:..:.::.||||.|  :.:::|..:...|        |    |:|
Mouse   228 ARWREERRKNYPTLANIERKKKLQLEKAKRGEVL--TTTQYGKMKGMSR--------HSQMAKIR 282

  Fly   210 FDPKNKKKRCAKGKANEKKKKRVGTDKANEALKQKETNEDKKEEEVNLCSLGNAKFGGTGQMPEY 274
            ...|:.|.|  :|.|.::.                            :..|||.......::|.
Mouse   283 SPGKHHKWR--RGGARQRA----------------------------VVGLGNHARDSKPEVPS- 316

  Fly   275 QHFKAKVQKKDNALSSFLGMYGSDSDEESEAESDDQNTADCSKQIPAQVESSQSMPSEITEMGPA 339
               ||.|    :.|.:.:     .||.||:.|...|.|.               :|.|:|   ||
Mouse   317 ---KANV----DPLGALI-----HSDSESDKEEKAQRTV---------------VPKEVT---PA 351

  Fly   340 LEASNTPNSVDNTQTCEDFTPMLEMTSSDQVPREISNISQITTSNSEPAKEDGSSDEGPDEEPFQ 404
            |              |.                .:|:...::.|:|||       :|.|.:...:
Mouse   352 L--------------CS----------------LMSSYGDVSGSDSEP-------EEAPIKTEAE 379

  Fly   405 RVTET-ITASDPVKPPPEPMEPKPQTAPKRAAPKRIYGL---NYKRARKQ-----TPNT----ML 456
            .:.|. :..|.|.|.|.:.::...:|..:.....:..||   :.||.:..     .|.|    :|
Mouse   380 VLAENHVLHSSPPKSPKQNVQTTGRTVSRSKWENQRNGLRKISLKRKKSHCHPLFEPRTHHPYLL 444

  Fly   457 SKLLESDIRHERNVLLQCVRHVCERNFFGI 486
            ..||..||||||||:|||||::.:::|||:
Mouse   445 EMLLAPDIRHERNVILQCVRYIIKKDFFGL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nufip	NP_649058.1	NUFIP1	126..180	CDD:402194	21/53 (40%)
Nufip1	NP_038773.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..77
		NUFIP1	207..259	CDD:287432	21/53 (40%)
		Bipartite nuclear localization signal	234..250		8/15 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..294		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..415		5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28HFB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8311
OMA	1	1.010	-	-		QHG49899
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006990
OrthoInspector	1	1.000	-	-		oto94438
orthoMCL	1	0.900	-	-		OOG6_106531
Panther	1	1.100	-	-	LDO	PTHR13309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5687
SonicParanoid	1	1.000	-	-		X5881
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.690