DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nufip and NUFIP1

DIOPT Version :9

Sequence 1:	NP_649058.1	Gene:	Nufip / 40043	FlyBaseID:	FBgn0036812	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_036477.2	Gene:	NUFIP1 / 26747	HGNCID:	8057	Length:	495	Species:	Homo sapiens

Alignment Length:	499	Identity:	129/499 - (25%)
Similarity:	191/499 - (38%)	Gaps:	140/499 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PSPKFGKPNGSTTSNHLYLTPSGMTLLPRSKQPPPMYGARGSTVPAKYLHQEQSSPVSVPAS--- 73
            |.|. |:|.....|...|...|........|...|  ..:.|..|.||  ..:.:..|:|.|
Human   103 PQPS-GQPWNFHASTSWYWRQSSDRFPRHQKSFNP--AVKNSYYPRKY--DAKFTDFSLPPSRKQ 162

  Fly    74 ------PPVYHSPPRPEFCHTCVMELANSQDMKLHLEQHEFCPADDCDFAALHNILERHIESNHI 132
                  .||:|.     ||.||.....|.:....|:.:|..||..||.|.|...|::.|..:.|.
Human   163 KKKKRKEPVFHF-----FCDTCDRGFKNQEKYDKHMSEHTKCPELDCSFTAHEKIVQFHWRNMHA 222

  Fly   133 TGTYVKVKKVWSEEELAAWRAERRKKFPTAANVELARLAKEQRIKRGERL---EASKSRFGNRED 194
            .|  :|..|:.:.||:|.||.||||.:||.||:|..:..|.::.|||..|   :..|.:..:|..
Human   223 PG--MKKIKLDTPEEIARWREERRKNYPTLANIERKKKLKLEKEKRGAVLTTTQYGKMKGMSRHS 285

  Fly   195 RQRTRGGPQGDHKVRFDPKNKKKRCAKGKANEK-KKKRVGTDKANE----ALKQKETNEDKKEEE 254
            :......|..:||.:.|  |.::|...|..:.. ..|..|..:||.    .|...::..||:|:
Human   286 QMAKIRSPGKNHKWKND--NSRQRAVTGSGSHLCDLKLEGPPEANADPLGVLINSDSESDKEEK- 347

  Fly   255 VNLCSLGNAKFGGTGQMPEYQHFKAKVQKKDNALSSFLGMYGSDSDEESEAESDDQNTADCSKQI 319
                             |::.....:|..   ||.|.:..|||.|..|||.|           :.
Human   348 -----------------PQHSVIPKEVTP---ALCSLMSSYGSLSGSESEPE-----------ET 381

  Fly   320 PAQVESSQSMPSEITEMGPALEASNTPNSVDNTQTCEDFTPMLEMTSSDQVPREISNISQITTSN 384
            |.:.|:.....:::.:       |:.|.|                 .|..|...:.|.|:..:.|
Human   382 PIKTEADVLAENQVLD-------SSAPKS-----------------PSQDVKATVRNFSEAKSEN 422

  Fly   385 SEPAKEDGSSDEGPDEEPFQRVTETITASDPVKPPPEPMEPKPQTAPKRAAPKRIYGLNYKRARK 449
            .:.:.|                                     :|.|||   |:.|. ||
Human   423 RKKSFE-------------------------------------KTNPKR---KKDYH-NY----- 441

  Fly   450 QT---PNT----MLSKLLESDIRHERNVLLQCVRHVCERNFFGI 486
            ||   |.|    :|..||..||||||||:|||||::.:::|||:
Human   442 QTLFEPRTHHPYLLEMLLAPDIRHERNVILQCVRYIIKKDFFGL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nufip	NP_649058.1	NUFIP1	126..180	CDD:402194	22/53 (42%)
NUFIP1	NP_036477.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108		2/5 (40%)
		NUFIP1	216..>253	CDD:287432	17/38 (45%)
		Bipartite nuclear localization signal	243..260		8/16 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..357		18/99 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..435		8/61 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28HFB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	107	1.000	Inparanoid score	I4935
Isobase	1	0.950	-	0	Normalized mean entropy	S8311
OMA	1	1.010	-	-		QHG49899
OrthoDB	1	1.010	-	-		D1394860at2759
OrthoFinder	1	1.000	-	-		FOG0006990
OrthoInspector	1	1.000	-	-		oto90855
orthoMCL	1	0.900	-	-		OOG6_106531
Panther	1	1.100	-	-	LDO	PTHR13309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5687
SonicParanoid	1	1.000	-	-		X5881
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.750