Protein Alignment Crtc and CRTC2

DIOPT Version :10

• Sequence 1: NP_001261997.1
• Gene: Crtc / 39970
• FlyBaseID: FBgn0036746
• Length: 889
• Species: Drosophila melanogaster
• Sequence 2: XP_005245003.1
• Gene: CRTC2 / 200186
• HGNCID: 27301
• Length: 698
• Species: Homo sapiens
• Alignment Length: 905
• Identity: 194/905 - (21%)
• Similarity: 278/905 - (30%)
• Gaps: 337/905 - (37%)

  Fly     2 ANPRKFSEKIALQKQKQAEGTAEFERIMKEVYATKRDEPPANQKILDGLVGGQEVSQSSPGAGNG 66
            :||||||||||||||:|||.||.||.:|.::.:|:...    ||:............|.|.. |.
Human    17 SNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQA----QKLRLAYTRSSHYGGSLPNV-NQ 76

  Fly    67 TGGGGSGSGSGASGGGASPDGLGGGGGSPTAYRESRGRSVGVGPMRRPSERKQDRSPYGSSSTQQ 131
            .|.|.:...|.......|.......|......|:.|..   |.|:||.: |..|.|||
Human    77 IGSGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRM---VSPLRRYT-RHIDSSPY------- 130

  Fly   132 TLDNGQLNPHLLGPPTAESLWR-----------------------RSSSDSALHQSALVAGFNSD 173
                   :|..|.|| .||.||                       |:|||||||.|.:
Human   131 -------SPAYLSPP-PESSWRRTMAWGNFPAEKGQLFRLPSALNRTSSDSALHTSVM------- 180

  Fly   174 VNSMGANYQQQQHQQQQQPG-QPRSHSPHH--GI-NRTMSPQAQRRKSPLLQPHQLQLQQLQQQQ 234
                      ....|...|| .|.|..|..  || :..|.|:....:.|.::.:.|..:.|.:
Human   181 ----------NPSPQDTYPGPTPPSILPSRRGGILDGEMDPKVFLFQVPAIEENLLDDKHLLK-- 233

  Fly   235 QQMQHQHQLHQQLQMQQLQQHQQQHQQQQQQQNTPYNNAKFTNPVFRPLQDQVNFANT------- 292
                                              |::..|.::...||...:|...|.
Human   234 ----------------------------------PWDAKKLSSSSSRPRSCEVPGINIFPSPDQP 264

  Fly   293 -------------GSLPDLTALQNYGPQQQQQQSQQQPSQQQQQLQQTLSPVMSPHNHRRERDQS 344
                         |||||||.| ::.|          |.......::|..|.:|..|.......:
Human   265 ANVPVLPPAMNTGGSLPDLTNL-HFPP----------PLPTPLDPEETAYPSLSGGNSTSNLTHT 318

  Fly   345 PSPFSPAGGGGGAGPG-----------------------------SPYQQQQ--HSPTGNTQQQQ 378
            .:... ...|.|.|||                             ||..|.|  ||.........
Human   319 MTHLG-ISRGMGLGPGYDAPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSL 382

  Fly   379 QQHQQPSNS---PHLSFTNLATTQAAVTTFNPLPTLGPHNATDYRQPPNPPSPRSSPGLLSSVSA 440
            .:|..|:.|   |.||...|:::.::.:|.:|:  ||.           |..|.|:||      |
Human   383 ARHVLPTTSLGHPSLSAPALSSSSSSSSTSSPV--LGA-----------PSYPASTPG------A 428

  Fly   441 TDLHSSAPASPIR-QQQQAHQQQQQQQQAQQQQQQFDNSYNSLNTSFHNQFEIFSLGDSNSSPEQ 504
            :..|...|.||:. ....|..::.|||..:|.......:.:|:...       ..|..|..|.:|
Human   429 SPHHRRVPLSPLSLLAGPADARRSQQQLPKQFSPTMSPTLSSITQG-------VPLDTSKLSTDQ 486

  Fly   505 Q----GFANNFVALDFD-----DLSGGGGGGPSGGGGSNGG---GLTNGYNKPEMLDFSELSGSP 557
            :    .:::..:.|...     .|...|....|....|:||   |..:.|            |:|
Human   487 RLPPYPYSSPSLVLPTQPHTPKSLQQPGLPSQSCSVQSSGGQPPGRQSHY------------GTP 539

  Fly   558 EASGNNNHMRRGVSNLNNNGLSNGVVGSTHNGSTNLNGAGN----NNSSSGGGTAQDPLGITTSP 618
            ...|.:.|.::                |.|...::.| .||    :..|.......||.|.:..|
Human   540 YPPGPSGHGQQ----------------SYHRPMSDFN-LGNLEQFSMESPSASLVLDPPGFSEGP 587

  Fly   619 ----VPSPLGCPSSPLPIPIPMSAQSSPQQQHHHHQQQQQQHHQQQHHQQQQLSLSLHHSPHHSP 679
                ...|:|.|..|                                          |...|.:.
Human   588 GFLGGEGPMGGPQDP------------------------------------------HTFNHQNL 610

  Fly   680 MHSPHHGNSPLSSSSPVSHNACSNSNVVMNHQQQQQQHHHQQHHHQGSSQSHTPTTANIPSIIFS 744
            .|...||:.|               |:::.....           .|.|:......|.:|....|
Human   611 THCSRHGSGP---------------NIILTGDSS-----------PGFSKEIAAALAGVPGFEVS 649

  Fly   745 DYSSNADYTREIFDSLDLDLGQMD--------VAGLQMLSDQNP-IMIADPNIEDSFRRD 795
                        ...|:|.||..|        :.||.||||  | .::.||.:|:|||.|
Human   650 ------------AAGLELGLGLEDELRMEPLGLEGLNMLSD--PCALLPDPAVEESFRSD 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crtc	NP_001261997.1	TORC_N	3..61	CDD:463738	26/57 (46%)
		TORC_C	<761..795	CDD:463740	17/42 (40%)
CRTC2	XP_005245003.1	TORC_N	18..72	CDD:463738	26/57 (46%)
		TORC_M	168..325	CDD:463739	42/221 (19%)
		TORC_C	620..697	CDD:463740	26/116 (22%)