DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment anchor and gpr155b

DIOPT Version :9

Sequence 1:	NP_001261995.1	Gene:	anchor / 39965	FlyBaseID:	FBgn0036741	Length:	957	Species:	Drosophila melanogaster
Sequence 2:	XP_017212067.1	Gene:	gpr155b / 100005567	ZFINID:	ZDB-GENE-110815-2	Length:	749	Species:	Danio rerio

Alignment Length:	870	Identity:	262/870 - (30%)
Similarity:	413/870 - (47%)	Gaps:	183/870 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VSMNNFYPALVQCFGIIICGYIAGRFKIISNAETKGLGTFVGTFALPSLIFLSLVELNWSAVNWS 109
            :|::..:|||::|||||:|||.|||..|||.|:..|||:||..||||:|:|.::|:|.:..|.||
Zfish    23 MSIDKLFPALLECFGIILCGYAAGRSGIISAAQVNGLGSFVSCFALPALLFKNMVQLQFQHVVWS 87

  Fly   110 FLLAMLVSKAVVFFAVLIISLLVARP-LNYARGGLMAIFCTQSNDFAIGYPIVMALYKDVHPEYA 173
            ||.::|::|..||..|.:::||||.| ..|::.||.|||.|||||||:|||||.|||::.|.||.
Zfish    88 FLWSVLIAKVCVFTLVCVLTLLVADPESKYSKAGLFAIFATQSNDFALGYPIVDALYRNSHSEYE 152

  Fly   174 SYLYLMAPISLAILNPVGLVLMEISKIIKNKEDVTRNPPLCPETCPAEQMSKRNRCLGERSILVF 238
            .|:||:||:||.:|||||..|.||.: .::..|              ...||.:        ::|
Zfish   153 QYIYLVAPVSLMLLNPVGFALCEIQR-WRHSSD--------------PNYSKLH--------VIF 194

  Fly   239 NTLIALFFNPLLLMTLLGVAGGFLFPNGLPEMVSSTLRVLGQSFSATALFLLGLKIVGGTGSERK 303
            ...:.:..||::.|.::|:...|:|...:|.::...:..|..||...|||.|||.:||......:
Zfish   195 TVTLQVLKNPIVFMVMVGIVSHFVFGGRVPVLLGEFVDGLADSFGGAALFYLGLNMVGQMSKLTR 259

  Fly   304 SIGFLLPGVLILVKILVLPLVIRQTVNIMQSGQNFN-DTTELSTFGFLYGTFPAAPGAFVIATQY 367
            |.|..|. :||..|:||:||:.|..|.::.:|.:.: :.:.||.:.||||.||.||...:.|.||
Zfish   260 STGVSLI-LLITAKLLVMPLMCRDMVELLDAGNSSSANHSSLSDYAFLYGVFPTAPSVAIYAAQY 323

  Fly   368 NMEVELVARSMVFCTFISAPLMFISAKMISLTNLKPLDYLHELDAFSFDISVAGAAACCIMLALL 432
            |||:|:|...||..||:|||:|::||.::::..::....:.||...||:||:....|....||::
Zfish   324 NMELEVVTSGMVISTFLSAPIMYVSAWLLTIPWMEASFLVKELQDVSFNISIVCLIALVWTLAVM 388

  Fly   433 IVTKRFKRMPQRITFCLVLSQLMCCIGVILWSKMEHVHRWPLYLQFLLFNI---GTYSTRLWTGL 494
            :::|:|:|||......|.|:||:.|:.::.|..:  :.:..::.|.|.|.:   ..|||.:||||
Zfish   389 LLSKKFRRMPHMFATNLFLAQLLACMSMLFWKFV--LKQGSVFGQILTFTLLYGSLYSTYVWTGL 451

  Fly   495 LAISLLFLQCRSLCFVLKLWPYM-LVFAWGVPAVLSALLIAFDSNVMSGEKHNPSFQYGNAQAAI 558
            ||.||..|....   .||:.|.: ::|.||:|.:....|:.....:  .:..:|:|.||:.|...
Zfish   452 LAFSLTLLGRNE---NLKVKPIVFIIFGWGIPFLTVGGLLMIGQRM--SDSLDPAFFYGSGQIVS 511

  Fly   559 SVFMLVMCFIVTVGCLVL---------HQRYKKRYEKYMT----YSRELSNPESESSDLHSTIST 610
            :|  :|:.|.:.:|.|.|         .|.|:...:..:|    .||.|......|||:..|.:.
Zfish   512 TV--VVLGFSIVLGGLSLMGLSRGAQEEQSYQALDQNSITGASENSRHLQTENQNSSDVDQTHTN 574

  Fly   611 TNLLSHTDQSSIRQSVRTASYSSSSDDEEMIPTAAGLPTSRSNGAASGGAGSGGGGCGSGNGTCC 675
            |::                                                            ||
Zfish   575 TDV------------------------------------------------------------CC 579

  Fly   676 SGGAPVSNSSTTSTVVVDIEDLLNRTRQRASGANNKDLNKIESAPATEEIRNQMCSSSFNCGPST 740
            |...|               |::              ...:..:|..        |:....|.|:
Zfish   580 SEPMP---------------DMI--------------AGHLNDSPVP--------SAGIVLGESS 607

  Fly   741 SRQSCQTIIERYEDQNRRGLEPLEHPSDADEHQTLKHTVLLITLLCSMFVGLAVSIWTLVMEGMS 805
            |....|                       :|.|..:|.:|.:.|:.||...|:..:|.|......
Zfish   608 SSLRVQ-----------------------EERQIARHVLLCLLLIVSMLANLSSCLWWLFSADPG 649

  Fly   806 GIYLELSFLDAFLNFGQGLIVLAVFITDIGELLMPVVKLWRKLWYGANVVSLPHWSNVRP----- 865
            .:||||.|..|..|:|||.:...:|..|...:::|    :||..  |.:.......|:.|
Zfish   650 RLYLELQFFCAVANYGQGFVSFGIFGLDEHLIILP----FRKRL--AALCGFSQEENLEPSAVPE 708

  Fly   866 ETKHICEQFRNHHLENCKKDIAKDR 890
            |.:..|.||..:|.:.|.:||.::|
Zfish   709 EIRLTCTQFVRYHKDQCVQDIVRNR 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
anchor	NP_001261995.1	Mem_trans	53..387	CDD:304621	142/335 (42%)
anchor	NP_001261995.1	DEP_GPR155	871..953	CDD:239890	8/20 (40%)
gpr155b	XP_017212067.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574451
Domainoid	1	1.000	165	1.000	Domainoid score	I3873
eggNOG	1	0.900	-	-		E1_2BZ3U
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1811
OMA	1	1.010	-	-		QHG49861
OrthoDB	1	1.010	-	-		D123487at33208
OrthoFinder	1	1.000	-	-		FOG0006319
OrthoInspector	1	1.000	-	-		otm25865
orthoMCL	1	0.900	-	-		OOG6_106133
Panther	1	1.100	-	-	LDO	PTHR22829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5681
SonicParanoid	1	1.000	-	-		X4600
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800