Protein Alignment Eip74EF and ETS1

DIOPT Version :10

• Sequence 1: NP_730288.1
• Gene: Eip74EF / 39962
• FlyBaseID: FBgn0000567
• Length: 883
• Species: Drosophila melanogaster
• Sequence 2: XP_047282481.1
• Gene: ETS1 / 2113
• HGNCID: 3488
• Length: 502
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 122/568 - (21%)
• Similarity: 176/568 - (30%)
• Gaps: 180/568 - (31%)

  Fly   352 IVKQSTS-----PAPQQQLQQQHHLQQQQQQQP-----HNGSTFAGATALLHIKTEQN----TLL 402
            :|:|..|     |......|..:|     ||:|     ...:|....|.|.|..::..    .||
Human    39 VVRQGPSNTYEDPRMNCGFQSNYH-----QQRPCYPFWDEMATQEVPTGLEHCVSDMECADVPLL 98

  Fly   403 TPLQLQQQQQQQQGLHGAAGNGGSSNGNNAHQQQQPLAIPQRPLLHNLLSGGAIHNPHHRNYTTA 467
            ||   ..::...|.|. |..:|.:       ::||.|.||:.|....        ..|.|::...
Human    99 TP---SSKEMMSQALK-ATFSGFT-------KEQQRLGIPKDPRQWT--------ETHVRDWVMW 144

  Fly   468 TTGSFPPSPADSGVSDVDSSSSGGQPCADELKARLGMPPATSASAAAAAAAAAAAAAHLHTGTFL 532
            ....|    :..||.......:|...||......|.:.|.                   ..|..|
Human   145 AVNEF----SLKGVDFQKFCMNGAALCALGKDCFLELAPD-------------------FVGDIL 186

  Fly   533 HPNL----------YQNNAANSLRNIWNRSVGVPDNYYGSS---GAGSGGTQPGGPGNPQTPGYL 584
            ..:|          ||.|..|.         ..|::.|.|.   ..|....|...|.....|.::
Human   187 WEHLEILQKEDVKPYQVNGVNP---------AYPESRYTSDYFISYGIEHAQCVPPSEFSEPSFI 242

  Fly   585 TTSY-----------------FNAPTAATAAASQRGTTINGYHSLHQQ-----QQQQQQSQQSQQ 627
            |.||                 .:.|:.......|..|..|.|.::.|:     .....::.:.:.
Human   243 TESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVTPDNMCMGRTSRGKL 307

  Fly   628 QQQLAHQQL-SHQQQQALHQQLSHQQQQQQQQQQQHPHSQLNGPHPHSHPHSHPHSHPHAGQHTH 691
            ..|.:.:.: |:.....|.|..|.|......|:.....|..:..:|.:.|:..|.
Human   308 GGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKPK---------- 362

  Fly   692 STIAAAAAAAAASVVSSSSSAVAAAAMLSASAAAAATAAAAAGGSQSVIQPATSSVSYDLSYMLE 756
                           .:....|...|.|:........||.|.......||
Human   363 ---------------GTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQ--------------- 397

  Fly   757 LGGFQQRKAKKPRKPKLEMGVKRRSREGSTTYLWEFLLKLLQDREYCPRFIKWTNREKGVFKLVD 821
                                            ||:|||:||.|:. |..||.||. :...|||.|
Human   398 --------------------------------LWQFLLELLTDKS-CQSFISWTG-DGWEFKLSD 428

  Fly   822 SKAVSRLWGMHKNKPDMNYETMGRALRYYYQRGILAKVDGQRLVYQFV 869
            ...|:|.||..||||.||||.:.|.|||||.:.|:.|..|:|.||:||
Human   429 PDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFV 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip74EF	NP_730288.1	ETS	786..872	CDD:197710	43/84 (51%)
ETS1	XP_047282481.1	SAM_PNT-ETS-1	112..199	CDD:176092	21/124 (17%)
		Ets1_N_flank	208..395	CDD:466113	33/220 (15%)
		ETS	395..479	CDD:197710	45/131 (34%)