Protein Alignment CG7542 and PLAT

DIOPT Version :10

• Sequence 1: NP_648995.3
• Gene: CG7542 / 39960
• FlyBaseID: FBgn0036738
• Length: 270
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 89/284 - (31%)
• Similarity: 133/284 - (46%)
• Gaps: 46/284 - (16%)

  Fly    11 VGSCTAVPLLTDVEPY--ITNGEPAEVGQFPYQAGL----NVSFGNWSTWCGGTLISHYWIITAA 69
            |.||:...|....:|.  |..|..|::...|:||.:    ..|.|. ...|||.|||..||::||
Human   293 VPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGE-RFLCGGILISSCWILSAA 356

  Fly    70 HCMD---GAESVTVYLG---AINIGDESEEGQERIMVEKSGIIVHSNYMASTVVNDISLIRLPAF 128
            ||..   ....:||.||   .:..|:|    :::..|||  .|||..:...|..|||:|::|.
Human   357 HCFQERFPPHHLTVILGRTYRVVPGEE----EQKFEVEK--YIVHKEFDDDTYDNDIALLQLK-- 413

  Fly   129 VGFTDRIRAA---SLPRRL-----NGQFPTYESIRAFASGWGRESDASDSVSPVLRYVEMPIMPH 185
               :|..|.|   |:.|.:     :.|.|.:....  .||:|:....|...|..|:...:.:.|.
Human   414 ---SDSSRCAQESSVVRTVCLPPADLQLPDWTECE--LSGYGKHEALSPFYSERLKEAHVRLYPS 473

  Fly   186 SLC--RMYWSGAVSEKMICM-STTSG------KSTCHGDSGGPLVYKQGNSSYLIGSTSFGTSMG 241
            |.|  :...:..|::.|:|. .|.||      ...|.||||||||........|:|..|:|  :|
Human   474 SRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWG--LG 536

  Fly   242 C-QVGFPAVFTRISSYLDWILNHI 264
            | |...|.|:|::::|||||.:::
Human   537 CGQKDVPGVYTKVTNYLDWIRDNM 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7542	NP_648995.3	Tryp_SPc	27..263	CDD:238113	84/263 (32%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005	1/2 (50%)
		Tryp_SPc	313..559	CDD:238113	83/261 (32%)