Protein Alignment CG12229 and PKM

DIOPT Version :10

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: XP_047288618.1
• Gene: PKM / 5315
• HGNCID: 9021
• Length: 609
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 106/477 - (22%)
• Similarity: 190/477 - (39%)
• Gaps: 72/477 - (15%)

  Fly    91 RRMLENGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLALEINGECCRVGRLRN 155
            |....:||:.:|.:|:.|           :..|..:.:::..|.....:||:..|...|.|.::.
Human   151 RLNFSHGTHEYHAETIKN-----------VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKG 204

  Fly   156 NCT--VMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLG-----DIVMIGREVRGKVV 213
            :.|  |.|.:|..:.:|.|.:|..|..:.|:: ::.:.....|::|     |..:|..:|:.|..
Human   205 SGTAEVELKKGATLKITLDNAYMEKCDENILW-LDYKNICKVVEVGSKIYVDDGLISLQVKQKGA 268

  Fly   214 KTLREALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLYMKDLEMAASLNANYVVLPKIRCKS 278
                :.|...:.:.|.:.|...:.||..  |:|.....:..::||:.....:.:.|....||..|
Human   269 ----DFLVTEVENGGSLGSKKGVNLPGA--AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAS 327

  Fly   279 FLRAVRQTL-NSDFNLKLIGMID-FEYVRSNMLDLLGIIKLVDYIWIP--DMFNVNCCVYNYIME 339
            .:..||:.| ....|:|:|..|: .|.||  ..|  .|::..|.|.:.  |: .:........:.
Human   328 DVHEVRKVLGEKGKNIKIISKIENHEGVR--RFD--EILEASDGIMVARGDL-GIEIPAEKVFLA 387

  Fly   340 DVLPISQCQK--KPVI-GTVPLERCSDFK-----RFELHD----FLWKVDAIHIQKSPWCNKYPL 392
            ..:.|.:|.:  |||| .|..||  |..|     |.|..|    .|...|.|.:........|||
Human   388 QKMMIGRCNRAGKPVICATQMLE--SMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPL 450

  Fly   393 -IVKKLMPIKDYRVGAVQNKMVLKSI-----LTSYQTIVNFIIRTISSIEC--QAIFLFTTCETA 449
             .|:....|......|:.:..:.:.:     :||..|....:....:|.:|  .||.:.|....:
Human   451 EAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRS 515

  Fly   450 SVALSRIEIYCPVYVMVPLEETDDAETITCKVELARALHLRRNMHPVLYTKDLNECSYSPIEFGV 514
            :..::|.....|:.            .:|...:.||..||.|.:.|||....:.|.....::..|
Human   516 AHQVARYRPRAPII------------AVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRV 568

  Fly   515 DFM----RKKGCLEVGDFVVTL 532
            :|.    :.:|..:.||.|:.|
Human   569 NFAMNVGKARGFFKKGDVVIVL 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:453956	97/438 (22%)
PKM	XP_047288618.1	Pyruvate_Kinase	120..608	CDD:238178	106/477 (22%)