Protein Alignment CG12229 and PKLR

DIOPT Version :10

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_000289.1
• Gene: PKLR / 5313
• HGNCID: 9020
• Length: 574
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 105/483 - (21%)
• Similarity: 194/483 - (40%)
• Gaps: 84/483 - (17%)

  Fly    91 RRMLENGTYTFHVDTVGNKPDELKAI----LDTMNIAISAHSAERELRLTTGLALEINGECCRVG 151
            |....:|::.:|.:::.|..:.:::.    |....:||               ||:..|...|.|
Human   116 RLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAI---------------ALDTKGPEIRTG 165

  Fly   152 RLRN--NCTVMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLGDIVMIGREVRGKVVK 214
            .|:.  ...|.|.:|..|.:|.|.::|.:|....|:| :....:..|.:|..:.|...:...||:
Human   166 ILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWV-DYPNIVRVVPVGGRIYIDDGLISLVVQ 229

  Fly   215 TL-REALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLY---MKDLEMAASLNANYVVLPKIR 275
            .: .|.|...:.:.|::.|...:.||    ....|| |.|.   ::||........:.|....:|
Human   230 KIGPEGLVTQVENGGVLGSRKGVNLP----GAQVDL-PGLSEQDVRDLRFGVEHGVDIVFASFVR 289

  Fly   276 CKSFLRAVRQTLNSD-FNLKLIGMID-FEYVR--SNMLDL----------LGIIKLVDYIWIPDM 326
            ..|.:.|||..|..: ..:|:|..|: .|.|:  ..:|::          |||....:.:::...
Human   290 KASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQK 354

  Fly   327 FNVNCCVYNYIMEDVLPISQCQKKPVIGTVPLERCSDFKRFELHD----FLWKVDAIHIQKSPWC 387
            ..:..|  |...:.|:..:|..:..:....|       .|.|..|    .|...|.|.:......
Human   355 MMIGRC--NLAGKPVVCATQMLESMITKPRP-------TRAETSDVANAVLDGADCIMLSGETAK 410

  Fly   388 NKYPL-IVKKLMPIKDYRVGAVQNKMVLKSI-----LTSYQTIVNFIIRTISSIEC--QAIFLFT 444
            ..:|: .||....|......||.::.:.:.:     |:...|.|..|....::.:|  .||.:.|
Human   411 GNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLT 475

  Fly   445 TCETASVALSRIEIYCPVYVMVPLEETDDAETITCKVELARALHLRRNMHPVLYTKDLNECSYSP 509
            |...::..|||   |.|...::         .:|...:.||.:||.|.:.|:|| ::..|..::.
Human   476 TTGRSAQLLSR---YRPRAAVI---------AVTRSAQAARQVHLCRGVFPLLY-REPPEAIWAD 527

  Fly   510 -----IEFGVDFMRKKGCLEVGDFVVTL 532
                 ::||::..:.:|.|.|||.|:.:
Human   528 DVDRRVQFGIESGKLRGFLRVGDLVIVV 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:453956	97/440 (22%)
PKLR	NP_000289.1	Pyruvate_Kinase	85..573	CDD:238178	105/483 (22%)