Protein Alignment CG12229 and Pklr

DIOPT Version :10

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: XP_006232655.1
• Gene: Pklr / 24651
• RGDID: 3336
• Length: 574
• Species: Rattus norvegicus
• Alignment Length: 495
• Identity: 106/495 - (21%)
• Similarity: 198/495 - (40%)
• Gaps: 91/495 - (18%)

  Fly    88 DELRRMLE-----------NGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLAL 141
            |.|:.|::           :|::.:|.:::.|..:.      |.:.|.|..|..     ...:||
  Rat   102 DRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREA------TESFATSPLSYR-----PVAIAL 155

  Fly   142 EINGECCRVGRLRN--NCTVMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLGDIVMI 204
            :..|...|.|.|:.  ...|.:.:|..|.:|.|..::.:|..:.|:| :.......|.:|..:.|
  Rat   156 DTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWV-DYHNITRVVAVGGRIYI 219

  Fly   205 GREVRGKVVKTL-REALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLY---MKDLEMAASLN 265
            ...:...||:.: .|.|...:...|::.|...:.||.    .:.|| |.|.   :.||......|
  Rat   220 DDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPN----TEVDL-PGLSEQDLLDLRFGVQHN 279

  Fly   266 ANYVVLPKIRCKSFLRAVRQTLNSD-FNLKLIGMID-FEYVR--SNMLDL----------LGIIK 316
            .:.:....:|..|.:.|||..|..: .|:|:|..|: .|.|:  ..:|::          |||..
  Rat   280 VDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEI 344

  Fly   317 LVDYIWIPDMFNVNCCVYNYIMEDVLPISQCQKKPVIGTVPLERCSDFKRFELHD----FLWKVD 377
            ..:.:::.....:..|  |...:.|:..:|..:..:....|       .|.|..|    .|...|
  Rat   345 PAEKVFLAQKMMIGRC--NLAGKPVVCATQMLESMITKARP-------TRAETSDVANAVLDGAD 400

  Fly   378 AIHIQKSPWCNKYPLIVKKLM---PIKDYRVGAVQNKMVLKSI-----LTSYQTIVNFIIRTISS 434
            .|.:........:|  |:.:|   .|......||.::.:.:.:     |:...|.|..|....:|
  Rat   401 CIMLSGETAKGSFP--VEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAS 463

  Fly   435 IEC--QAIFLFTTCETASVALSRIEIYCPVYVMVPLEETDDAETITCKVELARALHLRRNMHPVL 497
            .:|  .||.:.|....::..||:   |.|...::         .:|...:.||.:||.|.:.|:|
  Rat   464 FKCCAAAIIVLTKTGRSAQLLSQ---YRPRAAVI---------AVTRSAQAARQVHLSRGVFPLL 516

  Fly   498 YTKDLNECSYSP-----IEFGVDFMRKKGCLEVGDFVVTL 532
            | ::..|..::.     ::||::..:.:|.|.|||.|:.:
  Rat   517 Y-REPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVV 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:453956	96/442 (22%)
Pklr	XP_006232655.1	Pyruvate_Kinase	85..573	CDD:238178	106/495 (21%)