Protein Alignment CG12229 and pyk-2

DIOPT Version :10

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_001255515.1
• Gene: pyk-2 / 177984
• WormBaseID: WBGene00014001
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 506
• Identity: 105/506 - (20%)
• Similarity: 185/506 - (36%)
• Gaps: 110/506 - (21%)

  Fly    88 DELRRML-----------ENGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLAL 141
            :.||:|:           .:||:..|..|:       |.|          ..|.........:||
 Worm    50 ETLRKMINTGMNIARLNFSHGTHEAHAATI-------KTI----------REAAENAPFPVAIAL 97

  Fly   142 EINGECCRVGRLRNNC-TVMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLGDIVMIG 205
            :..|...|.|...||. .|.|..|..|.::||.|..:......:|. :.|.....||.|..:.|.
 Worm    98 DTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSMEFAATSSHIYA-DYRNLPKVVQPGSRIYID 161

  Fly   206 REVRGKVVKTLREALTVMIID-AGLVASYDFIELPRQCHALDPDLYPDLYMKDLE---MAASLNA 266
            ..:...:|::..|...:..|: .|.:.:...:.||.....|     |.:..||:|   .......
 Worm   162 DGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDL-----PAVTSKDIEDLLFGVEQGV 221

  Fly   267 NYVVLPKIRCKSFLRAVRQTL-NSDFNLKLIGMIDFEYVRSNMLDLLGIIKLVDYIWIP--DMFN 328
            :.:....||....:..:||.| ....::.:|..|:.|...:|..:   ||:..|.:.:.  |: .
 Worm   222 DIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDE---IIEASDGVMVARGDL-G 282

  Fly   329 VNCCVYNYIMEDVLPISQCQ--KKPVI-GTVPLE-----------RCSDFKRFELHDFLWKVDAI 379
            :........:...:.|::|.  .|||| .|..||           .|||.....|..    ||.:
 Worm   283 IEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDG----VDCV 343

  Fly   380 HIQKSPWCNKYPLIVKKLM------------PIKDYRVGAVQNKMVLKSILTSYQTIVNFIIRTI 432
            .:........||:....:|            .:|.:      .:::|.:...:..|....|....
 Worm   344 MLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHF------EELILHTKKPTGMTHTTAIAAVS 402

  Fly   433 SSIECQA---IFLFTTCETASVALSRIEIYCPVYVMVPLEETDDAETITCKVELARALHLRRNMH 494
            ::|.|:|   |.:.||.:||.:. ||.....|:.            |::....::|.|||.|.:.
 Worm   403 ATITCRAVAIILITTTGKTARLC-SRYRPPVPII------------TVSRDERISRQLHLHRGIF 454

  Fly   495 PVLYTK--------DLNECSYSPIEFGVDFMRKKGCLEVGDFVVTLEVGKE 537
            ||.|.|        |:.|    .:::||:..:.:|.:.:||.::.:...|:
 Worm   455 PVYYPKGRIDEWDVDVEE----RVQYGVNLGKTRGFIHLGDPLIVITGWKQ 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:453956	95/448 (21%)
pyk-2	NP_001255515.1	Pyruvate_Kinase	34..514	CDD:238178	105/506 (21%)