DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6652 and Lca5l

DIOPT Version :9

Sequence 1:	NP_648946.3	Gene:	CG6652 / 39905	FlyBaseID:	FBgn0036687	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_006248240.1	Gene:	Lca5l / 498065	RGDID:	1562512	Length:	734	Species:	Rattus norvegicus

Alignment Length:	589	Identity:	130/589 - (22%)
Similarity:	236/589 - (40%)	Gaps:	94/589 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VSQSEPNNLMAASAKSCESLFSASSRESASLIYQRSKPPPPQ-------QRGGVKGSGSMSSQ-- 70
            ||:.:|..|:              .:|.....|...|.|.|:       ::..:..:...|||
  Rat    85 VSRHQPEQLL--------------GKEKEKRKYNTCKFPQPKGQKDIPAEKRHIWNASFFSSQIQ 135

  Fly    71 ----NHSEIHQRVMSARNLRAKTFQNQLADAQAEIANLAHENRMLRTLHNRQSSALNKYEAHNAE 131
                ....:..|::|||..:.|..:|:|||...::.....||:.|:.|..|...|:..|......
  Rat   136 TIAKRRDTMTHRILSARLHKIKELKNELADIHRKLEATILENQFLKQLQLRHLKAIGTYVNSQNN 200

  Fly   132 LPKLLSSHAEELRMWQTKYRKLQAANKALELKLKQKEEIILTLSDQNKHYSQLNKDKNLDERQKL 196
            ||::...|..|::..:...||.|...:|:..||::.:..:|...|..:...:|::||||.||::|
  Rat   201 LPQITVKHQNEVKNLRQLLRKSQEKERAVSRKLRETDSELLRTKDALQALQRLSEDKNLAEREEL 265

  Fly   197 QEKLKSLEQRLEEKDNDMKLMARKVQLESKNIRQQLLNEQRKGKEVMLKLEKAKLEISGY----- 256
            ..:|..|..::|..|..::.:.::::|.:::..:||..|.||........:..:.|:...
  Rat   266 THRLTDLTAKMEANDKKIQNLEKQLRLNNRSFSRQLAKENRKTLAAQTATKALQAEVRQLQQKLK 330

  Fly   257 ---RKLEEYTLGTDKVNPLSSGRRTKLSGVTDEPD--KIDKLEKSMEMLDKAIE-KNNQSEFTAL 315
               |:||...:.|:::          |..:.|:.|  |:.. .||::...|::. .|.:.:.|..
  Rat   331 EKDRELEIKNIYTNRI----------LKNLHDKEDYPKVSS-TKSVQADRKSLPFVNVRHQETQK 384

  Fly   316 TDVMESESFYDFEKDSAEDKSGPNTPPSQIERQVGGRGGKLILPPATNHAKMGQKANRSTLSQVL 380
            :||    .|:..:...|:.........::|...:.....||   |....:|...:||.:.|..:.
  Rat   385 SDV----PFWITKDKKAKGNIVHKEKSTEINHDISYHVRKL---PRQEESKRKCEANLTVLKNMP 442

  Fly   381 SAQGKISVSSGKSAKSRIAVAVPKMES-VQVSKRREPETVSRLASAET--KPKQKPLEYE---YE 439
            |.:    ||..:.|..:|.....:..| .|....:|.|......|.||  :||::..:.|   ..
  Rat   443 SPR----VSWEQVATEQICAFHLECHSCTQTDLSKEVEHPKPQTSLETPRRPKERKEDQEKRAIP 503

  Fly   440 DDYEPAG------EDGDDDAYGMMSKMCEGEEPQDNSEENANESSLLKYSAYMDNKSSEG---DP 495
            ::.||..      ||.:|.|  :....|:..:..|..:  |.::         |:.|..|   |.
  Rat   504 EEAEPTAKGSEVPEDAEDKA--LARAACDVGDAGDAGD--AGDA---------DHASDAGDVRDV 555

  Fly   496 LEES----MEEYDGTD--GQQSQGSDDEDISVRAPRLKENMSSLRKQISNDFKERESFLKTFCRQ 554
            :|:|    ..|..|.:  |:....|:..|:.....|.|...|......:...:.....|.|.|||
  Rat   556 VEDSEVIGAHELPGANQAGEVHGASEAGDVEPGRGRRKTPRSRKHYSFTEATENLHHGLPTSCRQ 620

  Fly   555 ASNS 558
            ||.|
  Rat   621 ASGS 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6652	NP_648946.3	Lebercilin	82..257	CDD:292252	45/182 (25%)
		GBP_C	<151..252	CDD:303769	26/100 (26%)
		coiled coil	239..250	CDD:293879	0/10 (0%)
Lca5l	XP_006248240.1	Lebercilin	151..330	CDD:292252	45/178 (25%)
Lca5l	XP_006248240.1	SPEC	167..337	CDD:295325	39/169 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353399
Domainoid	1	1.000	89	1.000	Domainoid score	I7667
eggNOG	1	0.900	-	-		E1_28I5W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004975
OrthoInspector	1	1.000	-	-		otm44927
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16650
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.890