Protein Alignment Exn and Arhgef26

DIOPT Version :10

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_001074764.1
• Gene: Arhgef26 / 622434
• MGIID: 1918053
• Length: 869
• Species: Mus musculus
• Alignment Length: 984
• Identity: 266/984 - (27%)
• Similarity: 404/984 - (41%)
• Gaps: 233/984 - (23%)

  Fly  1098 SDHYYETLSPLGNKRHSTQLVRQSQDG--NRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSF 1160
            :|...|.|:.|...:...::.....|.  :||..:.|:|||...:.
Mouse    48 TDFPVEELAALPTPQTPVRVPADPDDRTVSRSPQLLSAHRRPVTNG------------------- 93

  Fly  1161 ETDSDDHGDGEPDLRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKL 1225
            .|.|.|:....|.||:               ||.|            ...:.:|..|||.:.
Mouse    94 RTVSPDYRAASPRLRR---------------PKSP------------LVSYAASGGSPKSTS--- 128

  Fly  1226 YENTPASTLFYVECSKRTEDV-------YENTDFGPERIPAPETKGPVHQ--EQAPVLRAKQKNG 1281
             ..|.||....:..:.||.|.       .:.|.....::.:|...|..|:  ...||.:..|..|
Mouse   129 -NGTVASPAALLSRASRTPDTPASCATDEDCTGVTASKVSSPIANGLAHKTDSSGPVSQTGQPAG 192

  Fly  1282 KSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCT 1346
            .                    ..|||:|.:          ||||     |.|.|        ...
Mouse   193 D--------------------LELAPSRLS----------PALP-----HKSSE--------QKL 214

  Fly  1347 PLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPP--------PPPMTGNKSPLDPE---RE 1400
            ||...|.                       :.|:.|.|        |..:...|..:.|:   .|
Mouse   215 PLQRLPS-----------------------QGNELPNPSVVLSTNSPAALKMGKQQIIPKSLASE 256

  Fly  1401 LDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVAS-SSG 1464
            :...::.|...|...........|...|      .|.||.|      |.|.......|..| ..|
Mouse   257 IKLSKSNSQNVESHRRLLKVRSMVEGLG------APLGHEG------EEGEVDNDMDSPGSLRRG 309

  Fly  1465 SSGVSTGNEAGLGDELSSEPHSLFSN---EPLYQ--MYSAAKLESITR----DLEAHGSSDG--- 1517
            ....|.......|.:..|...|...|   :|:.:  |....|..|:.|    .|:..|:.||
Mouse   310 LRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKAVMEDKEKFSSLGRIKKKILKGQGTFDGEEN 374

  Fly  1518 ------YEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSL 1576
                  |:|..|...:..||..|.:....::| ..:.|.|:.||::..|..:.:..|::..||..
Mouse   375 AVLYQNYKEKALDIDSDEEPEAKEQKAEERIV-IHHKPLRSTWSQLSAVKRNGLSQTVSQEERKR 438

  Fly  1577 QEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEA 1641
            |||.||:|:||.|||.||.:|.|.|.|.....|:  ::..:|..|||.|..|.|.|::..|||||
Mouse   439 QEAIFEVISSEHSYLLSLEILIRMFKNSKELTDT--MTKTERHHLFSNITDVWEASKKFFTELEA 501

  Fly  1642 CWQDNIMLLGLSRCIYEIAERH----FHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEA 1702
            ..|:||.:..:|    :|.|:|    |..||.:|.::....|||::|..:..|  |::.|.|:|:
Mouse   502 RHQNNIFIEDIS----DIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPS--FKEVLSRIES 560

  Fly  1703 SPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANR 1767
            ...|..|.:.|||:|||||:||||||:|.:..| :|.:..:||..|..|..|.|:|..|||.|.:
Mouse   561 HEDCRNLPMISFLILPMQRVTRLPLLMDTICQK-TPKDSPKYEVCKRALKEVSKLVRLCNEGARK 624

  Fly  1768 WEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLT 1832
            .|:...:..|..||||       .|.|..:.   :..|:||||||||..:   ||..| |.||::
Mouse   625 MERTEMMYTINSQLEF-------KIKPFPLV---SSSRWLVKRGELTAYV---EDTVL-FSKRMS 675

  Fly  1833 KISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKN------- 1890
            |..:|.|||:|:|::.|::.|..::|.||..|..|.:.:.|:      ::|....|||
Mouse   676 KQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDN------EELNSSPGKNPSTMLYS 734

  Fly  1891 -------LILMTLLENCDRKTVELVLSCPSVSDQQRWLQAM------RPPEAETPGEKLYESWDC 1942
                   |..:|:|.|...:.|:::|...:.|::.||:.|:      :||:..|          .
Mouse   735 RQSSATHLFTLTVLSNHASEKVDMLLGAETQSERARWITALGHSSGKQPPDRTT----------L 789

  Fly  1943 PQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRAR 2007
            .||....|:.:.:||.|.|::.|||.:.:::.||||:|||:|||..||||....:|:.......:
Mouse   790 TQVEIIRSFTAKQPDELSLQVADVVLIYQRVGDGWYEGERLRDGERGWFPMECAKEITCQATIDK 854

  Fly  2008 NLKQRHRLL 2016
            |:::..|||
Mouse   855 NVERMGRLL 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1762	CDD:459876	74/184 (40%)
		PH_ephexin	1805..1931	CDD:269929	46/145 (32%)
		SH3_ephexin1_like	1944..1998	CDD:212727	24/53 (45%)
Arhgef26	NP_001074764.1	PHA03247	<18..239	CDD:223021	55/306 (18%)
		RhoGEF	441..619	CDD:459876	75/186 (40%)
		PH_ephexin	641..779	CDD:269929	46/150 (31%)
		SH3_ARHGEF16_26	791..845	CDD:212871	24/53 (45%)