Protein Alignment CG9701 and GBA3

DIOPT Version :10

• Sequence 1: NP_648918.1
• Gene: CG9701 / 39872
• FlyBaseID: FBgn0036659
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001264154.1
• Gene: GBA3 / 57733
• HGNCID: 19069
• Length: 470
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 184/467 - (39%)
• Similarity: 271/467 - (58%)
• Gaps: 34/467 - (7%)

  Fly    43 GGWNADDKGESIWDFLTHTHPEKIVDRSNGDVSADSYHQWKRDVQMVKELHVGTYRFSLSWPRIM 107
            |||:||.||..:||..||...|::.....|||:..||..|:.|::.:|:|.:..|||||||.|::
Human    21 GGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSRLL 85

  Fly   108 PGGYMNHVSTAGIKYYSNLIDELLRYNITPMVTIYHWELPQKLQELGGWTNPEIIPLFKDYARLV 172
            |.|....::..||.||:.:||:||:..:||:||:||::|||.|::.|||.:..||..|..||:..
Human    86 PDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFDLPQTLEDQGGWLSEAIIESFDKYAQFC 150

  Fly   173 LEMYGDRVKIWTTVNEPWHVCEHGYGVDYMAPSYNYPGIPAYLCGHNLLKAHAEVVHMYRELFQP 237
            ...:|||||.|.|:||...:....|.:....|...:.|...|...|||:||||...|.|..||:.
Human   151 FSTFGDRVKQWITINEANVLSVMSYDLGMFPPGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRK 215

  Fly   238 RQGGRMGITLDTSWPEPRDPNSAEDREASERAMQFYVGWFGHPIFSKHGNYPKVMIERIRNLSKE 302
            :|.|.:.::|...|.||.||||..|:||::||:.|::..|..|||. .|:||:|:..:|.::|::
Human   216 KQKGMVSLSLFAVWLEPADPNSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIASMSQK 279

  Fly   303 QGFGARSRLPEFTTEEIHRIRGTSDFFGINSYTSNLVTSNGHNNTGK-----------FPVPSFN 356
            ||:.: |||||||.||...|:||:|||.:..||:.|:... .|..|:           ||.||:
Human   280 QGYPS-SRLPEFTEEEKKMIKGTADFFAVQYYTTRLIKYQ-ENKKGELGILQDAEIEFFPDPSW- 341

  Fly   357 HDMGVVESQEGVDWPGSGSVWLKVYPKGMYNLLMWIHREYNAPEIIVTENGV--SDRGGLEDYAR 419
                     :.||       |:.|.|.|:..||.:|...||.|.|.:||||.  ||...|:|..|
Human   342 ---------KNVD-------WIYVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQR 390

  Fly   420 VDYYNLYLSAVLDAME-DGANISGYIAWSLMDSYEWKAGFSEKFGLYHVDFNSPQRTRTPKISAR 483
            .:|:......:..|:: |..|:..|.||||:|::||..|:|.:|||:||||..|.|.|.|..||:
Human   391 WEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAK 455

  Fly   484 VFAQLCKTNTID 495
            .:|::.:.|.::
Human   456 EYAKIIRNNGLE 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9701	NP_648918.1	Glycosyl hydrolases	22..492	CDD:474034	183/462 (40%)
GBA3	NP_001264154.1	Glycosyl hydrolases	21..465	CDD:474034	183/463 (40%)