DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9701 and Lct

DIOPT Version :9

Sequence 1:	NP_648918.1	Gene:	CG9701 / 39872	FlyBaseID:	FBgn0036659	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001074547.1	Gene:	Lct / 226413	MGIID:	104576	Length:	1931	Species:	Mus musculus

Alignment Length:	514	Identity:	232/514 - (45%)
Similarity:	310/514 - (60%)	Gaps:	18/514 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FPNDFLWGVGSSSYQIEGGWNADDKGESIWDFLTHTHPEKIVDRSNGDVSADSYHQWKRDVQMVK 90
            ||..|:|...|:|||:||.|.||.||.||||..:|| |.||.:..||||:.||||:...||..::
Mouse  1381 FPKGFIWSAASASYQVEGAWRADGKGLSIWDTFSHT-PLKIGNDDNGDVACDSYHKIAEDVVALQ 1444

  Fly    91 ELHVGTYRFSLSWPRIMPGGYMNHVSTAGIKYYSNLIDELLRYNITPMVTIYHWELPQKLQELGG 155
            .|.|..||||:|||||:|.|....::.||:.||...||.||...|||.||:|||:|||.||::||
Mouse  1445 NLGVSHYRFSISWPRILPDGTTKFINEAGLNYYVRFIDALLAAGITPQVTMYHWDLPQALQDVGG 1509

  Fly   156 WTNPEIIPLFKDYARLVLEMYGDRVKIWTTVNEPWHVCEHGYGVDYMAPSYNY-PGIPAYLCGHN 219
            |.|..::..|||||.::....||:||.|.|:|||:.:..||||....||..:: ||...|..|||
Mouse  1510 WENETVVQRFKDYADVLFRRLGDKVKFWITLNEPFVIAAHGYGSGVSAPGISFRPGTAPYTAGHN 1574

  Fly   220 LLKAHAEVVHMYRELFQPRQGGRMGITLDTSWPEPRDPNSAEDREASERAMQFYVGWFGHPIFSK 284
            |:|||||..|:|...::..|||.:.||:.:.|.|||||::.||.||:.|.:||..|||.|||| |
Mouse  1575 LIKAHAEAWHLYNSTYRNSQGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIF-K 1638

  Fly   285 HGNYPKVMIERIRNLSKEQGFGARSRLPEFTTEEIHRIRGTSDFFGINSYTSNLVTSNGHNNTGK 349
            :|:||:||..|||:.|...|.. :|||||||..|..:|:||.||||.|.||:.|    .:|....
Mouse  1639 NGDYPEVMKTRIRDRSLAAGLN-KSRLPEFTESEKKKIQGTFDFFGFNHYTTVL----AYNLNYA 1698

  Fly   350 FPVPSFNHDMGVVESQEGVDWPGSGSVWLKVYPKGMYNLLMWIHREYNAPEIIVTENGVSDRGG- 413
            ..|.||:.|.||....:. .||.|||.|||:.|.|...:|.|:..|||.|.|.|||||||.||.
Mouse  1699 AAVSSFDADRGVASITDR-SWPDSGSFWLKMTPFGFRRILNWLKEEYNNPLIYVTENGVSRRGDP 1762

  Fly   414 -LEDYARVDYYNLYLSAVLDAMEDGANISGYIAWSLMDSYEWKAGFSEKFGLYHVDFNSPQRTRT 477
             |.|..|:.|...|::..|.|:.|..::.||..||:||::||..||:|:||::.|:.:.|...|.
Mouse  1763 ELNDTDRIYYLRSYINEALKAVRDKVDLRGYTVWSIMDNFEWATGFAERFGVHFVNRSDPSLPRI 1827

  Fly   478 PKISARVFAQLCKTNTIDWSYRPKLDEEQQLVAMAQLPAEARTSGASGAVSWSLMGILL 536
            ||.||:|:|.:.:.|...       |..|......|.|.:|..:.:........:|::|
Mouse  1828 PKASAKVYASIVRCNGFP-------DPAQGPHPCLQQPEDAGPTASPVKSEVPFLGLML 1879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9701	NP_648918.1	Glyco_hydro_1	22..492	CDD:304882	224/468 (48%)
Lct	NP_001074547.1	Glyco_hydro_1	86..>223	CDD:304882
		Glyco_hydro_1	380..849	CDD:304882
		Glyco_hydro_1	902..1368	CDD:278653
		Glyco_hydro_1	1377..1844	CDD:278653	225/470 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847266
Domainoid	1	1.000	452	1.000	Domainoid score	I505
eggNOG	1	0.900	-	-		E1_COG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42474
orthoMCL	1	0.900	-	-		OOG6_100193
Panther	1	1.100	-	-	O	PTHR10353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3725
SonicParanoid	1	1.000	-	-		X89
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770