Protein Alignment st and ABCG1

DIOPT Version :10

• Sequence 1: NP_524108.1
• Gene: st / 39836
• FlyBaseID: FBgn0003515
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: XP_024307909.1
• Gene: ABCG1 / 9619
• HGNCID: 73
• Length: 786
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 189/651 - (29%)
• Similarity: 321/651 - (49%)
• Gaps: 98/651 - (15%)

  Fly    55 RSYSKW----SPTEQGATLVWRDLCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSGKT 115
            |:|. |    .|.|:|                    .|.::...:|....|.|:|:||.||:||:
Human   190 RAYG-WGFPGDPMEEG--------------------YKTLLKGISGKFNSGELVAIMGPSGAGKS 233

  Fly   116 TLMSTLA-FRQPAGTVVQGDILING--RRIGPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRL 177
            |||:.|| :|:   |.::|.:||||  |.:..| .::|.|:.|||:.|..|||.|.:...|||:|
Human   234 TLMNILAGYRE---TGMKGAVLINGLPRDLRCF-RKVSCYIMQDDMLLPHLTVQEAMMVSAHLKL 294

  Fly   178 DRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEP 242
            ..:  .|.||.::||:|...||||.|.||.||      ||||:|||||.|:||:|||.::|.|||
Human   295 QEK--DEGRREMVKEILTALGLLSCANTRTGS------LSGGQRKRLAIALELVNNPPVMFFDEP 351

  Fly   243 TTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFF 307
            |:||||.|..|:|:.:..|||.|.:|:|||||||::||:.|:.:.:|:.|:..:.|...:.:.:.
Human   352 TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYL 416

  Fly   308 ANHGYYCPEAYNPADFLIGVLATDPGYEQASQRSA--QHLCDQFAVSSAAKQRDMLVNLEIHMAQ 370
            .:.|..||..:|||||::.|.:.:.|.:.:....|  :.:||      :..:||:..:.|::
Human   417 RDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCD------SDHKRDLGGDAEVN--- 472

  Fly   371 SGNFPF-----DTEVESFRGVAWYKR------------------FHVVWLRASLTLLRDPTIQWL 412
                ||     ..||:..:.:...::                  |.:::.|..|:::||..:..|
Human   473 ----PFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHL 533

  Fly   413 RFIQKIAMAFIIGACFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQGFPLFMRETR 477
            |....|.:..:||..:.|....:: .|.:..|.||..:....:..:...:..||....:|:||..
Human   534 RITSHIGIGLLIGLLYLGIGNEAK-KVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHL 597

  Fly   478 SGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMNVATACGCF 542
            :..||...||.|..:|.:|..|:.|:.:..|.||:|...|....|.:.|....:...||.:.|..
Human   598 NYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLL 662

  Fly   543 FSTAFNSVPLAMAYLVPLDYI-FMITSGIFIQVNSLPVAFWWTQFLSWMLYANEAMTAAQWSGVQ 606
            ...|..|:.:| .::.|:..| .::.||.|:..:::|....|..::|::.|..|.:..:.:.
Human   663 IGAASTSLQVA-TFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYG--- 723

  Fly   607 NITCFQESADLPC-------FHTGQDVLDKYSFNESNVYRNLLAMVGLYF-GFHLLGYYCLWRRA 663
                 .:..||.|       |...:.:|.:.....:.:|.:.: ::|::| ...|:.|:.|..:.
Human   724 -----LDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFI-VLGIFFISLRLIAYFVLRYKI 782

  Fly   664 R 664
            |
Human   783 R 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	3a01204	67..665	CDD:273361	183/635 (29%)
ABCG1	XP_024307909.1	3a01204	202..786	CDD:273361	185/638 (29%)