Protein Alignment st and ABCG2

DIOPT Version :10

• Sequence 1: NP_524108.1
• Gene: st / 39836
• FlyBaseID: FBgn0003515
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_004818.2
• Gene: ABCG2 / 9429
• HGNCID: 74
• Length: 655
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 195/636 - (30%)
• Similarity: 317/636 - (49%)
• Gaps: 67/636 - (10%)

  Fly    65 QGATLVWRDLCVYTNVGGSG------QRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAF 123
            :||.|.:.::|....: .||      ...|.|::|..|.::|| |.|::|.:|.||::|:..||.
Human    33 EGAVLSFHNICYRVKL-KSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAA 95

  Fly   124 RQ-PAGTVVQGDILINGRRIGPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERR 187
            |: |:|  :.||:||||..........||||.|||:.:|:|||.|:|.|.|.|||...::..|:.
Human    96 RKDPSG--LSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKN 158

  Fly   188 LIIKELLERTGLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQ 252
            ..|..:::..||...|.:::|:...:.| |||||||.:..:||:.:|.|||.|||||||||.:|.
Human   159 ERINRVIQELGLDKVADSKVGTQFIRGV-SGGERKRTSIGMELITDPSILFLDEPTTGLDSSTAN 222

  Fly   253 QLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEA 317
            .::..|..::::|.||:.:||||...:|..|:::.|||.||:.|.|..|.||.:|.:.||:| ||
Human   223 AVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHC-EA 286

  Fly   318 Y-NPADFLIGVLATDPG---------------YEQASQRS--AQHLCDQFAVSSAAKQRDMLVNL 364
            | |||||.:.::..|..               .|.:.|..  .:.|.:.:..||..|:    ...
Human   287 YNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKE----TKA 347

  Fly   365 EIHMAQSGNFPFDTEVESFRGVAWYKRF--HVVWL--RASLTLLRDPTIQWLRFIQKIAMAFIIG 425
            |:|....|.  ...::..|:.:::...|  .:.|:  |:...||.:|.....:.|..:.:..:||
Human   348 ELHQLSGGE--KKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIG 410

  Fly   426 ACFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQGFPLFMRETRSGLYSTGQYYAAN 490
            |.:.|....| .|:|...|.||.:.:...:..: |.:.||.....||:.|..||.|....|:...
Human   411 AIYFGLKNDS-TGIQNRAGVLFFLTTNQCFSSV-SAVELFVVEKKLFIHEYISGYYRVSSYFLGK 473

  Fly   491 ILA-LLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLV------MNVATACGCFFSTAFN 548
            :|: |||..::..:||..|.|::.||:....||.|....:::|      |.:|.|.|       .
Human   474 LLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAG-------Q 531

  Fly   549 SVPLAMAYLVPLDYIF-MITSGIFIQVNSLPVAFW--WTQFLSWMLYANEAMTAAQWSGVQNITC 610
            ||......|:.:.::| ||.||:.  ||...:|.|  |.|:.|...|...|:...::.|......
Human   532 SVVSVATLLMTICFVFMMIFSGLL--VNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPG 594

  Fly   611 FQESADLPCFH---TGQDVLDKYSFNES--NVYRNLLAMVGLYFGFHLLGY 656
            ...:.:.||.:   ||::.|.|...:.|  .:::|.:|:..:...|..:.|
Human   595 LNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAY 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	3a01204	67..665	CDD:273361	194/634 (31%)
ABCG2	NP_004818.2	3a01204	55..649	CDD:273361	189/613 (31%)