DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Adcy5

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_072122.2	Gene:	Adcy5 / 64532	RGDID:	71014	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	1581	Identity:	579/1581 - (36%)
Similarity:	809/1581 - (51%)	Gaps:	418/1581 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGG-----PGAGSGGAVAGGVGGGATHIFRSLSSESQKREWSKRLSLRGMRHGGAAGGPGGS-- 58
            |||.     ||..:..|.:...|||..|          :..|.:..|    |..|....||||
  Rat     1 MSGSKSVSPPGYAAQTAASPAPGGGPEH----------RAAWGEADS----RANGYPHAPGGSTR 51

  Fly    59 GTSSLASSKEESKHRKFFSRSASLRQAG--------SGG----GGVGV-----------GGVVGG 100
            |::..:......:.::   |.||..:.|        ||.    ||.|.           ||..||
  Rat    52 GSTKRSGGAVTPQQQQ---RLASRWRGGDDDEDPPLSGDDPLVGGFGFSFRSKSAWQERGGDDGG 113

  Fly   101 SGSHQASMELHVPGQEGRGTSSGAGSPQTQTQPSTPKKSNWEVIEHFNTSAKGGKAVVSSSLIAA 165
            .||.          ::.|| ::|.||  |:..|:                  ||....:::..||
  Rat   114 RGSR----------RQRRG-AAGGGS--TRAPPA------------------GGSGSSAAAAAAA 147

  Fly   166 GITRC---NIDESMDSTNSSSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSGGGGGTANGPVS 227
            |.|..   :::..::...........:   ...|..::.||.|. :..:.::||.|.||.....:
  Rat   148 GGTEVRPRSVEVGLEERRGKGRAAEEL---EPGTGTVEDGDGSE-DGGSSVASGSGTGTVLSLGA 208

  Fly   228 PSISFWFRLNRIILRLCSTHQFKNLQVEMLYQRYFLRMNQSNTTHILALLLALILALSCTLLVFT 292
            ..::        :|::..:.:|.:.::|.||||||.|:|||:.|.::|:|:.:.|    .:|.|
  Rat   209 CCLA--------LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCL----VMLAF- 260

  Fly   293 TLQLRRSTSLLLEISEIGLDANATVGNLTTATMKPPTLASSDQMTRGSSIPLLALASNGSWAGNG 357

  Rat   261 ----------------------------------------------------------------- 260

  Fly   358 AVGGELKSAHNHNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQD 422

  Rat   261 ----------------------------------------------------------------- 260

  Fly   423 AGLVKGGGIQTQLIVDTATDDDADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERD 487
                                                                        ||.|
  Rat   261 ------------------------------------------------------------HAAR- 264

  Fly   488 EVLNTSSNAGVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNE 552
                             |||   |::.|.::..  :|.|.||:.::|           ::.|.::
  Rat   265 -----------------PPL---QVVYLAVLAA--AVGVILIMAVLC-----------NRAAFHQ 296

  Fly   553 IFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVV 617
            ..:.|..|.::...||::|......||..:..|....:..||..||:||:|:|.|::.|:|||.:
  Rat   297 DHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL 361

  Fly   618 HLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLR 682
            ||...|..|| ||:.:    .::|:..::.....|:.||.||:|.|.:||:||.|||:||:|||.
  Rat   362 HLAISLHTNA-QDQFL----LKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH 421

  Fly   683 TQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQC 747
            :||||||||||||||||||||||||.||..:..|..|||||||:|:|||||||||.|||||:.||
  Rat   422 SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQC 486

  Fly   748 TAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIAL 812
            ||:|||..|||||||||:||||:||||||:|||||||||||||.|.|||||.||||:|||:||:|
  Rat   487 TAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISL 551

  Fly   813 VREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLD 877
            ||||..||||||||||:||||||||||.||||||||||||||||||:||..||:||||.||..|:
  Rat   552 VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN 616

  Fly   878 GDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKS----RNRLQVN--------------- 923
            ||||||.|.|.|||:|||:|.|||:||:.....|..:|:    .||.:.|
  Rat   617 GDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPF 681

  Fly   924 -----GN-ISKELRMMGHGTAQKHTSKFGFGD----SSESAKDPEDEVNEYLMRAIDARSIDHLR 978
                 || :|||::.|            ||.|    :::.:.:|||||:|:|.|||||||||.||
  Rat   682 YNHLGGNQVSKEMKRM------------GFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLR 734

  Fly   979 AEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALL 1043
            :||.:..||.|::..||:||:.:.|.....|..|:.||.|....:::.:...||..|:......|
  Rat   735 SEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFL 799

  Fly  1044 LLGFLVF---LVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQ 1105
            ||..:||   :.||.|:   .|:.::..|.:|..:::.|.|....::.|:.|:..:.||..:.:.
  Rat   800 LLALVVFISVIYACVKL---FPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNSKN 861

  Fly  1106 ME--LLQRRRFWLDVNGSISLNDTELNTKMYDAE------EPDCDF--YLAYNTFLLLTLLSMMS 1160
            :.  |.:.....::...:..:.::..|..:.|.:      :.:|:|  |..|:     .|||:::
  Rat   862 LVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYFTYS-----VLLSLLA 921

  Fly  1161 CATYQVLRILLKLLLL-----------------------LLASGSYMACSSNLYSRSREMSQELA 1202
            |:.:..:..:.||:|:                       ||.:.:.:..|:|..|:..|.:.::|
  Rat   922 CSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVA 986

  Fly  1203 NEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENIL 1267
            .:      ::..|.:..|:|||..|:.|.|:|.||||:||||||||||:||.||||||:||.|||
  Rat   987 LK------VVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNIL 1045

  Fly  1268 PVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDE 1332
            |..||.|||:||:..|:||::.|:.|.::||||.||||||||||.||||||||||||||||||||
  Rat  1046 PKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDE 1110

  Fly  1333 LLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFR 1397
            ::||:|||.:||||:.|:||||||||..:|.|:...:|:.|:||:|::|.|:::.:|.||||||:
  Rat  1111 IISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIKALADFAMKLMDQMKYINEHSFNNFQ 1175

  Fly  1398 MRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRG 1462
            |:||:||||||||||||.|||||||||.|||||||||||:.|.||||.:|.|:|....::|.|||
  Rat  1176 MKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRG 1240

  Fly  1463 SVDVKGKGSMITYFLKGRRPI 1483
            .|.|||||.|:||||.|..|:
  Rat  1241 VVKVKGKGEMMTYFLNGGPPL 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	81/196 (41%)
		CYCc	686..881	CDD:214485	157/194 (81%)
		Guanylate_cyc	722..895	CDD:278633	139/172 (81%)
		DUF1053	<949..1005	CDD:283888	29/59 (49%)
		CYCc	1259..1455	CDD:214485	131/195 (67%)
		Guanylate_cyc	1285..1479	CDD:278633	130/193 (67%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	164/751 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..196		51/246 (21%)
		Guanylate_cyc	461..634	CDD:306677	139/172 (81%)
		DUF1053	669..761	CDD:399378	37/103 (36%)
		Guanylate_cyc	1063..1257	CDD:306677	130/193 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340533
Domainoid	1	1.000	286	1.000	Domainoid score	I1534
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11213
Inparanoid	1	1.050	951	1.000	Inparanoid score	I320
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002306
OrthoInspector	1	1.000	-	-		otm45430
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1998
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.790