Protein Alignment CG43373 and adcy6a

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_017209219.1
• Gene: adcy6a / 570652
• ZFINID: ZDB-GENE-060221-1
• Length: 1203
• Species: Danio rerio
• Alignment Length: 1523
• Identity: 551/1523 - (36%)
• Similarity: 777/1523 - (51%)
• Gaps: 405/1523 - (26%)

  Fly    31 ESQKREWSKRLSLRGMRHGGAAGGPGGSGTSSLASSKEESKHRKFFS-----RSASLRQAGSGGG 90
            :.:|..|.:|...:..|..|          |||.:.:..|..|...:     :....:...|||.
Zfish    13 DDRKTAWGERNGKKSKRKVG----------SSLCNPRYMSCLRDVEAMEPPPQPPHAQATRSGGP 67

  Fly    91 GVGVGGVVGGSGSHQASMELHVPGQEGRGTSSGAGSPQTQTQPSTPKKSNWEVIEHFNTSAKGGK 155
            |.|.||..||:|:.              |...|                 |:. :|:.....||:
Zfish    68 GGGPGGGPGGTGNF--------------GMRCG-----------------WQE-DHYGKMGSGGE 100

  Fly   156 AVVSSSLIAAGITRCNIDESMDSTNSSSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSGGGGG 220
            .|        |:...::.                         .:.||....:.:.....|....
Zfish   101 GV--------GLKSVDLG-------------------------FEDGDVKGRKRDGLGGDGSSED 132

  Fly   221 TANGPVS-PSISFWFRLNRIILRLCSTHQFKNLQVEMLYQRYFLRMNQSNTTHILALLLALILAL 284
            ||:|..| .:...|.|    ::|:..:.:|::.::|.||||||.|:|||:    |.:|:.:::.:
Zfish   133 TASGTGSVTAADCWQR----VVRVFQSKKFQSRKLERLYQRYFFRLNQSS----LTMLMGVLVIV 189

  Fly   285 SCTLLVFTTLQLRRSTSLLLEISEIGLDANATVGNLTTATMKPPTLASSDQMTRGSSIPLLALAS 349
            ...:|.|
Zfish   190 CGVMLTF---------------------------------------------------------- 196

  Fly   350 NGSWAGNGAVGGELKSAHNHNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRM 414
                                                                             
Zfish   197 ----------------------------------------------------------------- 196

  Fly   415 REKRSLQDAGLVKGGGIQTQLIVDTATDDDADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYN 479
                                                                 |..:.|
Zfish   197 -----------------------------------------------------HCIHGP------ 202

  Fly   480 QISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCI 544
                                     |.:.|..::.:       ::.:||.:|::|
Zfish   203 -------------------------PDVVYASVLSV-------AMALFLALMVVC---------- 225

  Fly   545 LSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALI 609
             ::...::.::.:|||:::|..:.::|.....:.|..:..|....:..||:.||:||:|:|.|::
Zfish   226 -NRNGFHQDYMWMVSYLVIGVLIIVQVFGVLMVAPRSASEGIWWSVFFIYIIYTLLPVRMRAAVL 289

  Fly   610 GGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETR 674
            .|.:||.:||.|..|:|  ||:  |.: |::|...::..|..|:.|:.||:|.|.:||:||.|||
Zfish   290 SGGVLSAIHLLTTWRIN--QDD--EFL-WKQLSANVLIFLCTNIIGICTHYPAEVSQRQAFQETR 349

  Fly   675 QCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICG 739
            ..|:|||..||||||||||||||||||||||||.||..:..|..|||||||:|:|||||||||.|
Zfish   350 GYIQARLHLQRENQQQERLLLSVLPRHVAMEMKADINAKKEDMMFHKIYIQKHDNVSILFADIEG 414

  Fly   740 FTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGL 804
            ||||:.||||:|||..|||||||||:||:|:||||||:|||||||||||||||.|||||.||||:
Zfish   415 FTSLASQCTAQELVMTLNELFARFDKLASENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGV 479

  Fly   805 DMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHIT 869
            |||:||:|||||..||||||||||:||||||||||.||||||||||||||||||:||..||:|||
Zfish   480 DMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHIT 544

  Fly   870 KETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKS----RNRLQVNGN----- 925
            |.||:.|:||||||.|.|.|||:|||::.|||:|::.....|..:|:    ..|.:.|.|
Zfish   545 KATLQYLNGDYEVEPGFGGERNAYLKENSIETFLVLGCSQKRKDEKAMMAKMQRTRTNSNEALVP 609

  Fly   926 ------------ISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLR 978
                        .||..|.||   ..:.:||...|  ::.|.:|||||:|:|.|||||||||.||
Zfish   610 RWVPDRSFSRTKDSKVFRQMG---IDETSSKDNRG--AQEALNPEDEVDEFLGRAIDARSIDQLR 669

  Fly   979 AEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALL 1043
            .:|.:..||.|:.:.||:|||.:.|.....|..|:|||....|.:::|||..:|:.|.:.....:
Zfish   670 KDHVKKFLLTFQTSSLEKKYAKKVDDRFGGYVACTLLVFCFISFIQIVVFPHTLVMLGIYISIFI 734

  Fly  1044 LLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQ-ESGRQME 1107
            :|..::|:.|.:......|:.::..|.:|..:|..|.|....::.|:.::..:.||. ::.:.::
Zfish   735 ILANILFICAIYSCVKLFPAAMQTVSKKIVQSRTNSTLVGVFTIILVFISAFVNMFSCDTQKLVD 799

  Fly  1108 LLQRRRFWLD---------------VNG-SISLNDTELNTKMYDAEEPDCDF--YLAYNTFLLLT 1154
            .:.::..|..               .:| ||..|:|           |.|.|  |.:|:     .
Zfish   800 CVAKQLNWSSEMVTPCIIHNMSRSVADGLSICPNNT-----------PSCPFPEYFSYS-----V 848

  Fly  1155 LLSMMSCATY-QV-------LRILLKLLLLLLASGSYMACSSN----------LYSRSREMSQ-E 1200
            ||::::|:.: |:       |.:|::|..|||.....:|...|          :::.:.:.|. .
Zfish   849 LLTLLACSVFLQISSIGKLALMLLIQLTFLLLVEWPEVALFDNADLFVTANALVFNETLQWSNFN 913

  Fly  1201 LANEEALLRY------IIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYN 1259
            ...|:...|.      ::..:.|..|:|||..|:.|.|:|.||||:||||||||||:||.|||||
Zfish   914 TTTEQCTFRVTKVSLKVMTPVILTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYN 978

  Fly  1260 RKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLN 1324
            |:||.||||..||.|||:||:..|:||::.|:.|.::||||.||||||||||.||||||||||||
Zfish   979 RRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLN 1043

  Fly  1325 EIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVN 1389
            ||||||||::|||::|.:||||:.|:||||||||..:|.|:...||:||:||||:.|.::::.:|
Zfish  1044 EIIADFDEIISEEKYRQLEKIKTIGSTYMAASGLNDSTYDKEGRSHITALADYAMHLREQMKYIN 1108

  Fly  1390 MHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGR 1454
            .||||||:|:||:||||||||||||.|||||||||.|||||||||||:.|.||||.::.|:|..:
Zfish  1109 EHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLHQVLHSK 1173

  Fly  1455 GFELTCRGSVDVKGKGSMITYFLKGRRP 1482
            |::|.|||.:.|||||.|.||||....|
Zfish  1174 GYQLECRGVIKVKGKGEMTTYFLNDGPP 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	78/196 (40%)
		Guanylate_cyc	722..904	CDD:425528	144/181 (80%)
		Adcy_cons_dom	<949..1005	CDD:461877	29/55 (53%)
		Guanylate_cyc	1285..1479	CDD:425528	130/193 (67%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	112/568 (20%)
		Guanylate_cyc	397..559	CDD:425528	132/161 (82%)
		Adcy_cons_dom	609..697	CDD:461877	37/92 (40%)
		Guanylate_cyc	1004..1197	CDD:425528	129/192 (67%)