Protein Alignment CG43373 and adcy6b

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_002666536.2
• Gene: adcy6b / 560807
• ZFINID: ZDB-GENE-090127-2
• Length: 1174
• Species: Danio rerio
• Alignment Length: 1230
• Identity: 515/1230 - (41%)
• Similarity: 719/1230 - (58%)
• Gaps: 168/1230 - (13%)

  Fly   352 SWAGNGAVGGELKSAH--NHNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRM 414
            ||. ||     .|:|.  ||..|  ..:.||    |:.:||....|...||..          .:
Zfish     2 SWV-NG-----FKAARVDNHKTA--WGERNG----RKSRRKRGSSLCNPRYMS----------CL 44

  Fly   415 REKRSLQ--------DAGLVKGGGIQTQLI----------------VDTATDDDADVYTVASDDD 455
            |:..|::        .||........|:.:                ||.|. :||:.....:.||
Zfish    45 RDPESMEAPSQQYSRAAGGATSSNFSTRCVWQEDHYGRKGDVGLRAVDLAF-EDAETRQTKNGDD 108

  Fly   456 DDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPLILMQV 520
            .|..|....|.....:|..:|    ::|..:.:...::.              ..:|......::
Zfish   109 PDEGGVERKGPDRCFFTCLLR----LAHIFQSKKFKSAK--------------LERLYQRYFFRL 155

  Fly   521 DESVLVFL--IVMLICGIVYAF------------------------LLCILSKPAMNEIFLVLVS 559
            ::|.|..|  :::::||::.||                        |:.:.::...::.::.:||
Zfish   156 NQSSLTMLMGVLVVVCGVMLAFHCVQGPPDVAYASVLSVAMGLFLTLMVVCNRNGFHQDYMWIVS 220

  Fly   560 YVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLR 624
            |:::|..:.::|.....:.|.....|....:..||:.||:||:|:|.|:|.|.:||.:|:....|
Zfish   221 YLVMGVLVVVQVFGLLMVDPPSMPEGIWWTVFFIYIIYTLLPVRMRAAVITGAVLSTIHIVMAWR 285

  Fly   625 LNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQ 689
            .| ::|..:    :::|....:..|..|:.|:.||:|.|.:||:||.|||..|:||:..||||||
Zfish   286 FN-LEDSFL----YKQLCANAMIFLCTNIIGICTHYPAEVSQRQAFKETRGYIQARIHLQRENQQ 345

  Fly   690 QERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVR 754
            ||||||||||||||||||.||..:..|..|||||||:|:|||||||||.|||||:.||||:|||.
Zfish   346 QERLLLSVLPRHVAMEMKADINAKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVM 410

  Fly   755 LLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAV 819
            .|||||||||:||.|:||||||:|||||||||||||||.|||||.||||:|||:||:|||||..|
Zfish   411 TLNELFARFDKLAWENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGV 475

  Fly   820 NVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEV 884
            |||||||||:||||||||||.|||||||||||||||.||:||..||:||||.||:.|:||||||.
Zfish   476 NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANQMEAGGKAGRIHITKATLQYLNGDYEVEA 540

  Fly   885 GKGNERNSYLKDHQIETYLIVPGDIYRPHKKS----RNRLQVNGN-----------------ISK 928
            |.|.:||:||.::.|||:.::.....|..:|:    ..|.:.|.:                 .||
Zfish   541 GFGGDRNAYLNNNNIETFFVLGCSQKRKEEKAMMAKMQRARANSSEGLMPRWVPDRSFSRTKDSK 605

  Fly   929 ELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNV 993
            ..|.||...|....::     .::.|.:|||||:|:|.|||||||||.||.:|.:..||.|:..:
Zfish   606 VFRQMGIDEASSKDNR-----CAQEALNPEDEVDEFLGRAIDARSIDQLRKDHVKKFLLTFQTPL 665

  Fly   994 LERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKIN 1058
            ||:||:.:.|.....|..|:|||......:::|:|..:.|.|.|.....::|..::|:.|.:...
Zfish   666 LEKKYSKKVDDRFGGYVACTLLVFCFIVFIQIVIFPHTPLMLGLFITIFIILAHVLFICAIYSCV 730

  Fly  1059 FQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSIS 1123
            ...|..::..|.||..:|..|.|....::.|:.::..:.||        ...|......|.|.::
Zfish   731 KLFPVTLQTVSKRIVQSRINSTLVGVFTILLLFISAFVNMF--------TCDRTDMLACVAGHLN 787

  Fly  1124 LNDTELNTKMYD----AEEPDCDFYLAYNT---------FLLLTLLSMMSCATY--------QVL 1167
            ::::.....:|:    ||:|   |:|..:.         |....||:::.|:.:        .||
Zfish   788 ISESVTLCLLYNLSGLAEDP---FFLCLDQPSACPLPEYFTYSVLLTLLCCSVFLHISSIGKLVL 849

  Fly  1168 RILLKLLLLLLASGSYMACSSN---------LYS-RSREMSQELANEEALLRYIIDSIFLFAFML 1222
            .:.:::..|||.....::...|         ||: ......||...:.:|...|  .:.|..|:|
Zfish   850 MLFIQICFLLLIEWPLVSLLDNADLLDTVDALYAFNETNYCQETVTKVSLRVSI--PVILTVFVL 912

  Fly  1223 ALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYH 1287
            ||..|:.|.|:|.||||:||||||||||:||.||||||:||.||||..||.|||:||:..|:||:
Zfish   913 ALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 977

  Fly  1288 EQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATY 1352
            :.|:.|.::||||.||||||.|||.||||||||||||||||||||::|||:::.:||||:.|:||
Zfish   978 QSCECVAVMFASISNFSEFYTELEANNEGVECLRLLNEIIADFDEIISEEKYKQLEKIKTIGSTY 1042

  Fly  1353 MAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKP 1417
            ||||||..:|.|:...:|:.|:||||::|.::::.:|.||||||:|:||:||||||||||||.||
Zfish  1043 MAASGLNDSTYDKEGRTHILALADYAMRLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1107

  Fly  1418 QYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            |||||||.|||||||||||:.|.||||.::..:||.:|::|.|||.|.|||||.|.||||
Zfish  1108 QYDIWGNTVNVASRMDSTGVPDRIQVTTDLYHVLESKGYQLECRGLVKVKGKGDMTTYFL 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	77/222 (35%)
		Guanylate_cyc	722..904	CDD:425528	141/181 (78%)
		Adcy_cons_dom	<949..1005	CDD:461877	28/55 (51%)
		Guanylate_cyc	1285..1479	CDD:425528	127/193 (66%)
adcy6b	XP_002666536.2	AC_N	15..376	CDD:318454	106/400 (27%)
		Guanylate_cyc	378..562	CDD:425528	141/183 (77%)
		Adcy_cons_dom	590..678	CDD:461877	34/92 (37%)
		Guanylate_cyc	975..1169	CDD:425528	127/193 (66%)