DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and adcy6b

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	XP_002666536.2	Gene:	adcy6b / 560807	ZFINID:	ZDB-GENE-090127-2	Length:	1174	Species:	Danio rerio

Alignment Length:	1230	Identity:	515/1230 - (41%)
Similarity:	719/1230 - (58%)	Gaps:	168/1230 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 SWAGNGAVGGELKSAH--NHNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRM 414
            ||. ||     .|:|.  ||..|  ..:.||    |:.:||....|...||..          .:
Zfish     2 SWV-NG-----FKAARVDNHKTA--WGERNG----RKSRRKRGSSLCNPRYMS----------CL 44

  Fly   415 REKRSLQ--------DAGLVKGGGIQTQLI----------------VDTATDDDADVYTVASDDD 455
            |:..|::        .||........|:.:                ||.|. :||:.....:.||
Zfish    45 RDPESMEAPSQQYSRAAGGATSSNFSTRCVWQEDHYGRKGDVGLRAVDLAF-EDAETRQTKNGDD 108

  Fly   456 DDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPLILMQV 520
            .|..|....|.....:|..:|    ::|..:.:...::.              ..:|......::
Zfish   109 PDEGGVERKGPDRCFFTCLLR----LAHIFQSKKFKSAK--------------LERLYQRYFFRL 155

  Fly   521 DESVLVFL--IVMLICGIVYAF------------------------LLCILSKPAMNEIFLVLVS 559
            ::|.|..|  :::::||::.||                        |:.:.::...::.::.:||
Zfish   156 NQSSLTMLMGVLVVVCGVMLAFHCVQGPPDVAYASVLSVAMGLFLTLMVVCNRNGFHQDYMWIVS 220

  Fly   560 YVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLR 624
            |:::|..:.::|.....:.|.....|....:..||:.||:||:|:|.|:|.|.:||.:|:....|
Zfish   221 YLVMGVLVVVQVFGLLMVDPPSMPEGIWWTVFFIYIIYTLLPVRMRAAVITGAVLSTIHIVMAWR 285

  Fly   625 LNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQ 689
            .| ::|..:    :::|....:..|..|:.|:.||:|.|.:||:||.|||..|:||:..||||||
Zfish   286 FN-LEDSFL----YKQLCANAMIFLCTNIIGICTHYPAEVSQRQAFKETRGYIQARIHLQRENQQ 345

  Fly   690 QERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVR 754
            ||||||||||||||||||.||..:..|..|||||||:|:|||||||||.|||||:.||||:|||.
Zfish   346 QERLLLSVLPRHVAMEMKADINAKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVM 410

  Fly   755 LLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAV 819
            .|||||||||:||.|:||||||:|||||||||||||||.|||||.||||:|||:||:|||||..|
Zfish   411 TLNELFARFDKLAWENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGV 475

  Fly   820 NVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEV 884
            |||||||||:||||||||||.|||||||||||||||.||:||..||:||||.||:.|:||||||.
Zfish   476 NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANQMEAGGKAGRIHITKATLQYLNGDYEVEA 540

  Fly   885 GKGNERNSYLKDHQIETYLIVPGDIYRPHKKS----RNRLQVNGN-----------------ISK 928
            |.|.:||:||.::.|||:.::.....|..:|:    ..|.:.|.:                 .||
Zfish   541 GFGGDRNAYLNNNNIETFFVLGCSQKRKEEKAMMAKMQRARANSSEGLMPRWVPDRSFSRTKDSK 605

  Fly   929 ELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNV 993
            ..|.||...|....::     .::.|.:|||||:|:|.|||||||||.||.:|.:..||.|:..:
Zfish   606 VFRQMGIDEASSKDNR-----CAQEALNPEDEVDEFLGRAIDARSIDQLRKDHVKKFLLTFQTPL 665

  Fly   994 LERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKIN 1058
            ||:||:.:.|.....|..|:|||......:::|:|..:.|.|.|.....::|..::|:.|.:...
Zfish   666 LEKKYSKKVDDRFGGYVACTLLVFCFIVFIQIVIFPHTPLMLGLFITIFIILAHVLFICAIYSCV 730

  Fly  1059 FQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSIS 1123
            ...|..::..|.||..:|..|.|....::.|:.::..:.||        ...|......|.|.::
Zfish   731 KLFPVTLQTVSKRIVQSRINSTLVGVFTILLLFISAFVNMF--------TCDRTDMLACVAGHLN 787

  Fly  1124 LNDTELNTKMYD----AEEPDCDFYLAYNT---------FLLLTLLSMMSCATY--------QVL 1167
            ::::.....:|:    ||:|   |:|..:.         |....||:::.|:.:        .||
Zfish   788 ISESVTLCLLYNLSGLAEDP---FFLCLDQPSACPLPEYFTYSVLLTLLCCSVFLHISSIGKLVL 849

  Fly  1168 RILLKLLLLLLASGSYMACSSN---------LYS-RSREMSQELANEEALLRYIIDSIFLFAFML 1222
            .:.:::..|||.....::...|         ||: ......||...:.:|...|  .:.|..|:|
Zfish   850 MLFIQICFLLLIEWPLVSLLDNADLLDTVDALYAFNETNYCQETVTKVSLRVSI--PVILTVFVL 912

  Fly  1223 ALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYH 1287
            ||..|:.|.|:|.||||:||||||||||:||.||||||:||.||||..||.|||:||:..|:||:
Zfish   913 ALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 977

  Fly  1288 EQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATY 1352
            :.|:.|.::||||.||||||.|||.||||||||||||||||||||::|||:::.:||||:.|:||
Zfish   978 QSCECVAVMFASISNFSEFYTELEANNEGVECLRLLNEIIADFDEIISEEKYKQLEKIKTIGSTY 1042

  Fly  1353 MAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKP 1417
            ||||||..:|.|:...:|:.|:||||::|.::::.:|.||||||:|:||:||||||||||||.||
Zfish  1043 MAASGLNDSTYDKEGRTHILALADYAMRLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1107

  Fly  1418 QYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            |||||||.|||||||||||:.|.||||.::..:||.:|::|.|||.|.|||||.|.||||
Zfish  1108 QYDIWGNTVNVASRMDSTGVPDRIQVTTDLYHVLESKGYQLECRGLVKVKGKGDMTTYFL 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	77/222 (35%)
		CYCc	686..881	CDD:214485	156/194 (80%)
		Guanylate_cyc	722..895	CDD:278633	137/172 (80%)
		DUF1053	<949..1005	CDD:283888	28/55 (51%)
		CYCc	1259..1455	CDD:214485	127/195 (65%)
		Guanylate_cyc	1285..1479	CDD:278633	127/193 (66%)
adcy6b	XP_002666536.2	AC_N	15..376	CDD:318454	106/400 (27%)
		Guanylate_cyc	378..562	CDD:306677	141/183 (77%)
		DUF1053	590..677	CDD:310728	34/91 (37%)
		Guanylate_cyc	975..1169	CDD:306677	127/193 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1642
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	942	1.000	Inparanoid score	I332
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002306
OrthoInspector	1	1.000	-	-		otm24286
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4931
SonicParanoid	1	1.000	-	-		X1998
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.850