DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Adcy6

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001257714.1	Gene:	Adcy6 / 25289	RGDID:	2035	Length:	1180	Species:	Rattus norvegicus

Alignment Length:	1464	Identity:	564/1464 - (38%)
Similarity:	748/1464 - (51%)	Gaps:	374/1464 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 VGGSGSHQASME----LHVPGQEGRGTSSGAGSPQTQTQPSTPKKSNWEVIEHFNTSAKGG---- 154
            |..|||.::||.    |.||..:.|.|:.|..:.|.:     |:::         |.|:|.
  Rat     5 VARSGSGRSSMSWFSGLLVPKVDERKTAWGERNGQKR-----PRQA---------TRARGFCAPR 55

  Fly   155 -----KAVVSSSLIAAGITRCNIDESMDSTNSSSTCHSPMIYQRDETQLLQPGDA---------- 204
                 |.|...|...|..|||                 |.   :||..:.:.|..
  Rat    56 YMSCLKNVEPPSPTPAARTRC-----------------PW---QDEAFIRRAGPGRGVELGLRSV 100

  Fly   205 ----SNLEANNPMSSGGGGGTANGPVSPSI------SFWFRLNRIILRLCSTHQFKNLQVEMLYQ 259
                .:.|...||      |||.  |:|..      |.|.||.::.    .:.||::.::|.|||
  Rat   101 ALGFDDTEVTTPM------GTAE--VAPDTSPRSGPSCWHRLAQVF----QSKQFRSAKLERLYQ 153

  Fly   260 RYFLRMNQSNTTHILALLLALILALSCTLLVFTTLQLRRSTSLLLEISEIGLDANATVGNLTTAT 324
            |||.:||||:    |.||:|:::.|...||.|                           :...|.
  Rat   154 RYFFQMNQSS----LTLLMAVLVLLMAVLLTF---------------------------HAAPAL 187

  Fly   325 MKPPTLASSDQMTRGSSIPLLALASNGSWAGNGAVGGELKSAHNHNIADFEADHNGQLVWRRQKR 389
            .:|..:|            ||..||
  Rat   188 PQPAYVA------------LLTCAS---------------------------------------- 200

  Fly   390 KHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQTQLIVDTATDDDADVYTVASDD 454

  Rat   201 ----------------------------------------------------------------- 200

  Fly   455 DDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPLILMQ 519

  Rat   201 ----------------------------------------------------------------- 200

  Fly   520 VDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFN 584
                 ::|:::|::|           ::.:..:..:.:||||:||...|::|..:.|..|.....
  Rat   201 -----VLFVVLMVVC-----------NRHSFRQDSMWVVSYVVLGILAAVQVGGALAANPRSPSA 249

  Fly   585 GSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALL 649
            |..|.:..:|:|||:||:|:|.|::.|:.||.:||.....||     ..:...|::|...:|..|
  Rat   250 GLWCPVFFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWHLN-----NGDPFLWKQLGANVVLFL 309

  Fly   650 LANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQP 714
            ..|..||.||:|.|.:||:||.|||..|:|||..|.||:|||||||||||:|||||||:||..:.
  Rat   310 CTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKK 374

  Fly   715 RDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLG 779
            .|..|||||||:|:|||||||||.|||||:.||||:|||..|||||||||:||||:||||||:||
  Rat   375 EDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG 439

  Fly   780 DCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQF 844
            |||||||||||.|.|||||.||||:|||:||:|||||..||||||||||:||||||||||.||||
  Rat   440 DCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQF 504

  Fly   845 DVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDI 909
            ||||||||||||||:||..||:|||:.||:.|:||||||.|:|.|||:|||:..|||:||:....
  Rat   505 DVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFLILGASQ 569

  Fly   910 YRPHKKSR----NRLQVNG-----------------NISKELRMMGHGTAQKHTSKFGFGDSSES 953
            .|..:|:.    .|.:.|.                 ..||..|.||...:.|...      .::.
  Rat   570 KRKEEKAMLVKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKENR------GAQD 628

  Fly   954 AKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLL 1018
            |.:|||||:|:|.|||||||||.||.:|.:..||.|:...||:||:.:.|.....|..|:|||..
  Rat   629 ALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFC 693

  Fly  1019 GTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFA 1083
            ....::.:||..|.|.|.:..|..|||...|.:.|........|:.::|.|..|..:|..|....
  Rat   694 FICFIQFLVFPHSALILGIYAGIFLLLLVTVLICAVCSCGSFFPNALQRLSRSIVRSRVHSTAVG 758

  Fly  1084 FASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELN------TKMYDAEEPDCD 1142
            ..||.|:.::.:..||..|...:.....|...|..:...:.:..:||      ..:.:...|.|.
  Rat   759 VFSVLLVFISAIANMFTCSHTPLRTCAARMLNLTPSDVTACHLRQLNYSLGLEAPLCEGTAPTCS 823

  Fly  1143 F--YLAYNTFLLLTLLSMMSCATYQVLRILLKLL---------LLLLASG-------SY-MACSS 1188
            |  |     |:...|||:::.:.:..:..:.||:         ||||..|       :| :..|.
  Rat   824 FPEY-----FVGSVLLSLLASSVFLHISSIGKLVMTFVLGFIYLLLLLLGPPATIFDNYDLLLSV 883

  Fly  1189 NLYSRSREMSQEL---ANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKE 1250
            :..:.|.|....|   |.....|:| :..:.|..|.|||..|:.|.|:|.||||:||||||.|||
  Rat   884 HGLASSNETFDGLDCPAVGRVALKY-MTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKE 947

  Fly  1251 DMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNE 1315
            :||.||||||:||.||||..||.|||:||:..|:||::.|:.|.::||||.||||||||||.|||
  Rat   948 EMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE 1012

  Fly  1316 GVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQ 1380
            |||||||||||||||||::||||||.:||||:.|:||||||||.|:|.|:|..||:||:||||::
  Rat  1013 GVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMR 1077

  Fly  1381 LFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQ 1445
            |.::::.:|.||||||:|:||:|:||||||||||.|||||||||.|||:|||||||:.|.||||.
  Rat  1078 LMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTT 1142

  Fly  1446 EMQQILEGRGFELTCRGSVDVKGKGSMITYFLKG 1479
            ::.|:|..:|::|.|||.|.|||||.|.||||.|
  Rat  1143 DLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNG 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	77/196 (39%)
		CYCc	686..881	CDD:214485	154/194 (79%)
		Guanylate_cyc	722..895	CDD:278633	138/172 (80%)
		DUF1053	<949..1005	CDD:283888	28/55 (51%)
		CYCc	1259..1455	CDD:214485	133/195 (68%)
		Guanylate_cyc	1285..1479	CDD:278633	133/193 (69%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:292831	136/631 (22%)
		CYCc	346..541	CDD:214485	154/194 (79%)
		Guanylate_cyc	382..566	CDD:278633	145/183 (79%)
		DUF1053	594..680	CDD:283888	34/91 (37%)
		CYCc	956..1157	CDD:214485	135/200 (68%)
		Guanylate_cyc	982..1176	CDD:278633	133/193 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1534
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	951	1.000	Inparanoid score	I320
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002306
OrthoInspector	1	1.000	-	-		otm45430
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1998
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.960