Protein Alignment CG43373 and acy-4

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_504486.4
• Gene: acy-4 / 178949
• WormBaseID: WBGene00000071
• Length: 1013
• Species: Caenorhabditis elegans
• Alignment Length: 998
• Identity: 380/998 - (38%)
• Similarity: 556/998 - (55%)
• Gaps: 163/998 - (16%)

  Fly   525 LVFLIVMLICGIVYAF------LLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSF 583
            |:..|:.|:..|:..|      |:||.|          ::|.||:....::..:|:|
 Worm   122 LILCILTLVISILSFFHAKRTELVCIAS----------IISCVIISACTSMRTSVTY-------- 168

  Fly   584 NGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVAL 648
                   :||:.||::||:.....:.....|:.:..:    :..:.|..|   .::.:|..::.:
 Worm   169 -------LLIFSTYSLLPMSFMLMIFSTFALTFLVAF----IGVLMDYNV---GFDIILTRVMMV 219

  Fly   649 LLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQ 713
            :|.|:.|...::|.|..|||.|.|||:|:::|:...:|..:||::||:|||:::|.|:|.|:...
 Worm   220 ILVNVVGSLVYYPTEFVQRKTFHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKDMQET 284

  Fly   714 PRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 778
            ..:..||||||:::|::|||||||||||:|:.:...::||.:|||||||||::|:.|.|:|||:|
 Worm   285 HEERMFHKIYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKIL 349

  Fly   779 GDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQ 843
            |||||||.|:||.:.:||...||||.|||:||.||||:..||||||||||||:.|||||||.|||
 Worm   350 GDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLGLKKWQ 414

  Fly   844 FDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGD 908
            ||||||||||||.|||||:.||||||..|...|.|.|.:|.|.|..|:.:|:..:|:|:|:|...
 Worm   415 FDVWSNDVTLANQMESGGLAGRVHITDATRSYLKGAYILEEGNGGSRSKFLEKEKIKTWLVVDRS 479

  Fly   909 --------------IYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPE- 958
                          :..|.|.:|       .|||:.|:.|..|..:       |.|:.:....|
 Worm   480 PDYDNICQEATNHPVMVPWKSTR-------GISKQERLTGMSTRTR-------GASTRNGLSEEE 530

  Fly   959 ---DEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLER-----KYASEPDRM--------LC 1007
               :.|:.:|.:.|.|...::.:..||::..|.:|...:|.     ||...|.::        :|
 Worm   531 VLVENVDSHLRQGIQAIHQENWKTMHCKNWSLKYKQVRVENKFVRLKYKDIPFQVTLYVAIVAIC 595

  Fly  1008 VYFYCSLLVLLGTS-IMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLR 1071
            :.....|:.|:..| :.::.:..:|::...| |.||:....||.||
 Worm   596 IGIKFGLMNLVSFSFVPQMFIVLTSVMIFIL-TRALIKHARLVSLV------------------- 640

  Fly  1072 IHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDA 1136
                  |..||...|:.:::   |:.|::.           :|..||......|.|
 Worm   641 ------IGVLFILLSIQIVI---LMGMYES-----------KFTCDVEKCFKNNYT--------- 676

  Fly  1137 EEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRI--LLKLLLLLLASGSYMACSSNLYSRSREMSQ 1199
                 ||   :..|.:.||      ||..:|.:  :.|||:.::...|:....:....|..:.
 Worm   677 -----DF---FEIFEICTL------ATCVILSVDFMTKLLMSMIYFSSFTVLITAKLIRINQY-- 725

  Fly  1200 ELANEEALL-RYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLL 1263
                 |||| .|....:.....:|.::|.:.::|...|.||||||||.:|:..|:.....||.:|
 Worm   726 -----EALLSTYANFCVLSCLTLLLVVFSTRRSELISRYDFIWKLQALDEQLQMKRKHEQNRSVL 785

  Fly  1264 ENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIA 1328
            |||||.|||:||:.....:..||||..|:.||:||::..|.:||:|.:||||||||||||||||:
 Worm   786 ENILPSHVAKHFVEDATSVSKLYHESRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLNEIIS 850

  Fly  1329 DFDELLSE----ERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVN 1389
            |||::|.:    |.|:.|||||:...|||.||||....|.  :.|||.|:|.:|.:|..|:|..|
 Worm   851 DFDQILDQILDREEFKKIEKIKTISTTYMVASGLAGRECG--DNSHVEAIALFARELLVKLESTN 913

  Fly  1390 MHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGR 1454
            :||||||.:|||||:|||||||||:.||.||||||:|||||||||.|:...||||:|::.|||..
 Worm   914 IHSFNNFNLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPL 978

  Fly  1455 GFELTCRGSVDVKGKGSMITYFL 1477
            |:...|||.::|||||.|.|:||
 Worm   979 GYNFECRGQINVKGKGMMETFFL 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	50/200 (25%)
		Guanylate_cyc	722..904	CDD:425528	115/181 (64%)
		Adcy_cons_dom	<949..1005	CDD:461877	14/64 (22%)
		Guanylate_cyc	1285..1479	CDD:425528	117/197 (59%)
acy-4	NP_504486.4	AcyC	93..455	CDD:441717	161/364 (44%)
		Guanylate_cyc	293..448	CDD:425528	105/154 (68%)
		Guanylate_cyc	807..1003	CDD:425528	117/197 (59%)