Protein Alignment Agpat4 and AGPAT2

DIOPT Version :10

• Sequence 1: NP_648887.1
• Gene: Agpat4 / 39819
• FlyBaseID: FBgn0036622
• Length: 380
• Species: Drosophila melanogaster
• Sequence 2: NP_006403.2
• Gene: AGPAT2 / 10555
• HGNCID: 325
• Length: 278
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 57/300 - (19%)
• Similarity: 104/300 - (34%)
• Gaps: 101/300 - (33%)

  Fly    28 LLLILLVRPFDKKLSRSLAYYLHYSFYCI----------LVC-------------VAEWYAGSKL 69
            |||:|||     :|||:..:|...:.||.          |||             :..|:..|..
Human    12 LLLLLLV-----QLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFK 71

  Fly    70 RVY---IDPQDEQKFFGKEHGLLLMNHTYEIDWLTAW-MITDKLGNLGGTKAYAKKMLRYVPVLG 130
            ..|   .:.:|.::.......:::.||...:|.:... ::.::...:      ||:.|.::..:|
Human    72 YFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQI------AKRELLFLGPVG 130

  Fly   131 WVWWMAEFIFLDRNFEKDKVVIKTQLKE--------VFSYPDPVWLLLNAEGTRFTPAKHELSVK 187
            .:.::....|::|......:.:...|.|        |:.||         ||||
Human   131 LIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYP---------EGTR----------- 175

  Fly   188 FAEERGLPLLKHHLIPRTKG-FTTSLPTMRGICPAIYDINLAF---KKNAEPKPTMLSQLNGEPV 248
              .:.|      .|:|..|| |..::.....|.|.:|....:|   ||......|:..|:
Human   176 --NDNG------DLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQV----- 227

  Fly   249 EPYMYIRRVPLDVVPDDEKEAAAWMQDFFAEKDKIIDSFH 288
                      |:.:|.....|        |:...::|:.|
Human   228 ----------LEAIPTSGLTA--------ADVPALVDTCH 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Agpat4	NP_648887.1	PLN02380	12..366	CDD:178006	56/299 (19%)
AGPAT2	NP_006403.2	PlsC	62..253	CDD:439974	41/244 (17%)
		HXXXXD motif. /evidence=ECO:0000250|UniProtKB:Q9D517	98..103		1/4 (25%)
		EGTR motif. /evidence=ECO:0000305|PubMed:21873652	172..175		2/2 (100%)