DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4950 and chadla

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_017210255.1	Gene:	chadla / 565474	ZFINID:	ZDB-GENE-121205-4	Length:	791	Species:	Danio rerio

Alignment Length:	547	Identity:	124/547 - (22%)
Similarity:	198/547 - (36%)	Gaps:	192/547 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFC 163
            ||:...|..||.:|||.....||.|:|...::.:::...|.|.:.|::|||:.|.|..|...:|.
Zfish    56 LDLKKNNFGELPKNAFKHTPYLTQLSLQGCSVQAVREGAFRGLSRLLQLDLTNNNIDILYQESFD 120

  Fly   164 GLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRLIF 228
            ||.::.|:||..|.::|:|...|.....|..:|...|.|..:....|:.|..|:.::||:|.|..
Zfish   121 GLSSLKQLYLDRNRIEEIHPGAFAALNSLNLLSLTYNQLVYLPNMAFQGMMNIQMLHLSHNSLNN 185

  Fly   229 IHPDTFADAASLENLVLSYNELKNFQL-TEKNIVHQLHLDNNY---------------LTNLTIN 277
            :..:.||...:|.:|.|.:|||:.|.. |...::...|||.:|               ||:|::
Zfish   186 LATEAFAGLLALTHLNLDHNELQYFPTKTMTRLIEVTHLDMSYNPMTYLVEESVVMPKLTHLSL- 249

  Fly   278 ATRFVRASHN---QISELFLHQSLHIETLDLSANKLSSISNITNITHMLYLDVSDNPI------- 332
                   .||   .:||..:..|..|..||||.|:||.|..:...||:..|:::.|||
Zfish   250 -------KHNALQDLSESTISLSPVISHLDLSFNQLSYIQALAASTHLTSLNLTGNPIRCTCLLR 307

  Fly   333 -------------------------GPL-----------------------------------NI 337
                                     .||                                   .:
Zfish   308 DLKLWALKSGIRLFGVCAWPPHLSDEPLENVQEQDLRCRPQDEWTSDVIEEGTKEEEEGVQEKTV 372

  Fly   338 STFSQLKR--------------------------------------LRG---------------- 348
            ||....|.                                      :||
Zfish   373 STAKSKKTRKCPKDCLCEYAAQHATCENRGHTKVPSGFPRKTLLLDMRGNHFHYLPSKSFPGIPE 437

  Fly   349 ---LNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMF-----VPYLTNLKKFLIDGNGL 405
               |:|....|.|::.|.|...|.|..|.||.|.|:.|:..:|     :.||.      ::.|.|
Zfish   438 VVSLHLDSCKIHEIEGGAFQGMKNLIYLYLSDNQLSSLDAKVFEGAHEIMYLH------LEDNKL 496

  Fly   406 TELQGNRTFSEAFPQLQKLGVSRN---------------RFNCSYLHH----LLIPPSL---PES 448
            |....:.|.:. .|:|.:|.:.||               :....||::    .::|.:|   |:.
Zfish   497 THFPSSATLTH-IPKLLELHLERNLIAKLEPSGLLSPVLQLTGLYLNNNSIATIVPKALDPAPKL 560

  Fly   449 VVLNIE-------PDTNLDETPHIRDV 468
            .||::|       |...||..|.:.::
Zfish   561 DVLHLEDNVLTDVPSDALDHAPLLTEL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	8/19 (42%)
		LRR_8	118..178	CDD:290566	20/59 (34%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		leucine-rich repeat	144..167	CDD:275380	10/22 (45%)
		leucine-rich repeat	168..191	CDD:275380	7/22 (32%)
		LRR_8	192..250	CDD:290566	17/57 (30%)
		leucine-rich repeat	192..215	CDD:275380	6/22 (27%)
		LRR_RI	<207..432	CDD:238064	77/387 (20%)
		leucine-rich repeat	216..239	CDD:275380	7/22 (32%)
		leucine-rich repeat	240..299	CDD:275380	20/77 (26%)
		LRR_8	299..356	CDD:290566	24/180 (13%)
		leucine-rich repeat	300..321	CDD:275380	9/20 (45%)
		leucine-rich repeat	322..345	CDD:275380	8/89 (9%)
		LRR_8	344..405	CDD:290566	21/122 (17%)
		leucine-rich repeat	346..365	CDD:275380	7/37 (19%)
		leucine-rich repeat	370..394	CDD:275380	10/28 (36%)
		leucine-rich repeat	395..420	CDD:275380	4/24 (17%)
chadla	XP_017210255.1	LRRNT	22..49	CDD:279764
		leucine-rich repeat	55..76	CDD:275380	8/19 (42%)
		LRR_8	75..135	CDD:290566	20/59 (34%)
		leucine-rich repeat	77..100	CDD:275380	6/22 (27%)
		leucine-rich repeat	101..124	CDD:275380	10/22 (45%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		LRR_8	172..231	CDD:290566	19/58 (33%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		leucine-rich repeat	221..243	CDD:275380	4/21 (19%)
		LRR_8	242..300	CDD:290566	21/65 (32%)
		leucine-rich repeat	244..267	CDD:275380	8/30 (27%)
		leucine-rich repeat	417..437	CDD:275380	2/19 (11%)
		LRR_8	436..496	CDD:290566	18/65 (28%)
		leucine-rich repeat	438..461	CDD:275380	6/22 (27%)
		LRR_RI	<451..658	CDD:238064	34/144 (24%)
		leucine-rich repeat	462..485	CDD:275380	8/22 (36%)
		leucine-rich repeat	486..510	CDD:275380	6/30 (20%)
		leucine-rich repeat	511..535	CDD:275380	4/23 (17%)
		LRR_8	535..594	CDD:290566	12/53 (23%)
		leucine-rich repeat	536..559	CDD:275380	4/22 (18%)
		leucine-rich repeat	560..583	CDD:275380	6/22 (27%)
		leucine-rich repeat	584..608	CDD:275380	0/4 (0%)
		leucine-rich repeat	609..633	CDD:275380
		leucine-rich repeat	634..656	CDD:275380
		LRRCT	664..>699	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910